Cdk8 - cyclin-dependent kinase 8 Gene

Species: Mus musculus

Gene Type: protein coding
Gene ID: 264064

About Cdk8

Chromosome 5: 146,168,040-146,239,684 forward strand.GRCm39:CM000998.3

This gene has 9 transcripts (splice variants), 217 orthologues, 25 paralogues and is associated with 17 phenotypes. Ubiquitous expression in adrenal adult (RPKM 21.2), ovary adult (RPKM 18.4) and 28 other tissues.

Summary

Predicted to enable RNA polymerase II CTD heptapeptide repeat kinase activity and cyclin-dependent protein serine/threonine kinase activity. Predicted to be involved in protein phosphorylation. Predicted to act upstream of or within phosphorylation. Part of mediator complex. Is expressed in embryo. Orthologous to human CDK8 (cyclin dependent kinase 8). [provided by Alliance of Genome Resources, Apr 2022]

Cdk8 Products (3)

mRNA Protein Name
NM_001359991.1 NP_001346920.1 cyclin-dependent kinase 8 isoform 3
NM_001359990.1 NP_001346919.1 cyclin-dependent kinase 8 isoform 2
NM_153599.4 NP_705827.2 cyclin-dependent kinase 8 isoform 1

Gene Ontology

  • Molecular Function
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
20720539 MGI
Cellular Component GO Annotation Evidence References Source
part of mediator complex IDA
IDA: Inferred from direct assay
15340084 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Cdk8 Protein Structure

STKc_CDK8

STKc_CDK8: cd07868 (2 - 334)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 464 a.a.
Protein Preferred Names Protein Names

cyclin-dependent kinase 8

  • cell division protein kinase 8

  • mediator complex subunit CDK8

  • mediator of RNA polymerase II transcription subunit CDK8

Cdk8 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
Cdk8 Q8R3L8 Med12 Mus musculus A2AGH6
Anti Bait CoIP
20720539
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

  • Clinical Phase
  • Pre-clinical Phase

Clinical Phase

Bioactive Molecules (4)
Cat. No. 상품명 효과
Purity Phase
HY-X0009 Tambiciclib Inhibitor 99.68% Phase 2
HY-137478 KB-0742 Inhibitor 99.63% Phase 2
HY-101800 Senexin B Inhibitor 99.09% Phase 1
HY-111388B Romaciclib hydrochloride Inhibitor 99.98% Phase 1

Pre-clinical Phase

Bioactive Molecules (51)
Cat. No. 상품명
효과
Purity
Rare Diseases
HY-N0400 Wogonin Inhibitor 99.83% Unkown
HY-120350 BI-1347 Inhibitor 99.85% Unkown
HY-126675A AS2863619 Inhibitor 98.02% Unkown
HY-111388A Romaciclib monohydrochloride Inhibitor 99.29% Unkown
HY-15681 Senexin A Inhibitor 99.58% Unkown
HY-101611 MSC2530818 Inhibitor 99.62% Unkown
HY-137478A KB-0742 dihydrochloride Inhibitor 98.77% Unkown
HY-19984 CCT-251921 Inhibitor 99.12% Unkown
HY-122586 BRD6989 Inhibitor 99.54% Unkown
HY-145121 DS96432529 Inhibitor 99.93% Unkown
HY-12280 THZ2 Inhibitor 99.03% Unkown
HY-156366 SNX7886 Degrader 99.71% Unkown
HY-126675 AS2863619 free base Inhibitor 99.87% Unkown
HY-111518 JH-XI-10-02 Inhibitor 99.73% Unkown
HY-149209 LL-K8-22 Degrader 99.06% Unkown
HY-12293 LY2857785 Inhibitor 99.21% Unkown
HY-139875 JH-XVI-178 Inhibitor 98.87% Unkown
HY-143889 Senexin C Inhibitor 99.19% Unkown
HY-149974 CDK8-IN-13 Inhibitor 99.14% Unkown
HY-168683 CDK8 ligand 1 Degrader 99.88% Unkown
HY-151463 CDK8-IN-11 Inhibitor 98.18% Unkown
HY-111388 SEL120-34A Inhibitor 99.49% Unkown
HY-111427 CDK8/19-IN-1 Inhibitor 98.08% Unkown
HY-X0009A Tambiciclib dimaleate Inhibitor 99.53% Unkown
HY-170813 P162-0948 Inhibitor 99.39% Unkown
HY-103492 CDK8-IN-1 Inhibitor 98.62% Unkown
HY-125001 JH-VIII-49 Inhibitor / Unkown
HY-148561 CDK8-IN-12 Inhibitor 99.74% Unkown
HY-15681A Senexin A hydrochloride Inhibitor / Unkown
HY-169541 CDK8-IN-18 Inhibitor / Unkown
HY-168846 CDK8/19-IN-3 Inhibitor / Unkown
HY-184544 CDK8 ligand 2 / Unkown
HY-176282 CDK8-IN-19 Inhibitor / Unkown
HY-182986 LS-Q2 Inhibitor / Unkown
HY-147716 CDK8-IN-6 Inhibitor / Unkown
HY-183074 RO8323 Inhibitor / Unkown
HY-180124 CDK8-IN-20 Inhibitor / Unkown
HY-176281 PI3Kα-IN-26 Inhibitor / Unkown
HY-147527 CDK8-IN-5 Inhibitor / Unkown
HY-147717 CDK8-IN-7 Inhibitor / Unkown
HY-158377 CDK8/19-IN-2 Inhibitor / Unkown
HY-151371 CDK8-IN-10 Inhibitor / Unkown
HY-169633 CDK8-IN-17 Inhibitor / Unkown
HY-184727 CDK8/BRD4-IN-1 Inhibitor / Unkown
HY-162600 CDK8-IN-15 Inhibitor / Unkown
HY-137478B KB-0742 hydrochloride Inhibitor / Unkown
HY-187035 SNX631 Inhibitor / Unkown
HY-114178 CDK8-IN-2 Inhibitor / Unkown
HY-N0400R Wogonin (Standard) Inhibitor / Unkown
HY-183423 MK256 Inhibitor / Unkown
HY-171174 CDK8-IN-16 Inhibitor / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Cdk8 NCBI NCBI:1024