HSPA1L - heat shock protein family A (Hsp70) member 1 like Gene

Also Known as HSP70T; hum70t; HSP70-1L; HSP70-HOM

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 3305

About HSPA1L

Cytogenetic location: 6p21.33 Genomic coordinates (GRCh38): 6:31,809,619-31,815,283 (from NCBI)

This gene has 1 transcript (splice variant), 1 gene allele, 110 orthologues and 13 paralogues. Biased expression in testis (RPKM 35.8) and ovary (RPKM 2.3).

Summary

This gene encodes a 70kDa heat shock protein. In conjunction with Other heat shock proteins, this protein stabilizes existing proteins against aggregation and mediates the folding of newly translated proteins in the cytosol and in organelles. The gene is located in the major histocompatibility complex class III region, in a cluster with two closely related genes which also encode isoforms of the 70kDa heat shock protein. [provided by RefSeq, Jul 2008]

HSPA1L Products (1)

mRNA Protein Name
NM_005527.4 NP_005518.3 heat shock 70 kDa protein 1-like

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables heat shock protein binding IPI
IPI: Inferred from physical interaction
17182002 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
25036637 GOA
enables ubiquitin protein ligase binding IPI
IPI: Inferred from physical interaction
24270810 GOA
enables unfolded protein binding IDA
IDA: Inferred from direct assay
21231916 GOA
Biological Process GO Annotation Evidence References Source
involved in positive regulation of protein targeting to mitochondrion IMP
IMP: Inferred from mutant phenotype
24270810 GOA
involved in protein refolding IDA
IDA: Inferred from direct assay
21231916 GOA
Cellular Component GO Annotation Evidence References Source
part of COP9 signalosome IDA
IDA: Inferred from direct assay
18850735 GOA
located in cytosol IDA
IDA: Inferred from direct assay
21231916 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

HSPA1L Protein Structure

HSP70

HSP70: Hsp70 protein (8 - 614)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 500
  • 600
  • 641 a.a.
Protein Preferred Names Protein Names

heat shock 70 kDa protein 1-like

  • epididymis secretory sperm binding protein

HSPA1L Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
HSPA1L P34931 TRIM38 Homo sapiens O00635
Y2H Prey Pooling
32296183
Intra
HSPA1L P34931 TRIM38 Homo sapiens O00635
Y2H Array
32296183
Intra
HSPA1L P34931 BAG4 Homo sapiens O95429
Y2H Array
32296183
Intra
HSPA1L P34931 BAG4 Homo sapiens O95429
Y2H Prey Pooling
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

HSPA1L Antibodies

Cat. No. 상품명 신청 Reactivity
HY-P86906 HSPA1L Antibody (YA6599) WB, ICC/IF, IHC-P Human, Mouse, Rat

Related Diseases

Diseases Alias
Uveoparotid Fever

  • Heerfordt'S Syndrome
Anthracosis

  • Black Lung

  • Coal Workers' Pneumoconiosis

  • Melanoedema

  • Black Lung Disease

  • Pneumoconiosis

  • Coal Miner'S Pneumoconiosis

  • Coal Workers' Lung

  • Coal Worker'S Pneumoconiosis

  • Coal Workers Pneumoconiosis

  • Coal Miners' Lung

  • Coal Miners' Pneumoconiosis

  • Coal Pneumoconiosis

  • Colliers' Anthracosis

  • Colliers' Lung

  • Lung Melanosis

  • Miners' Asthma

  • Miners' Lung

  • Pneumomelanosis

  • Cwp - [Coalworkers Pneumoconiosis]

  • Fibrosis Of Lung With Anthracosilicosis

  • Lung Fibrosis With Anthracosis

  • Miners' Pneumoconiosis

  • Carbon Lung

  • Coalworker Lung

  • Collier'S Asthma

  • Anthracosilicosis

  • Lung Anthracosis
Visceral Leishmaniasis

  • Kala-Azar

  • Leishmaniasis, Visceral

  • Infection By Visceral Leishmaniasis

  • Leishmaniasis Visceral

  • Sahib Disease

  • Ponos

  • Burdwan Fever

  • Mard El Bicha

  • Sirkari Disease

  • Indian Visceral Leishmaniasis

  • Dumdum Fever

  • Visceral Leishmaniasis Due To Leishmania Donovani
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. 상품명
효과
Purity
Rare Diseases
HY-RS06426 HSPA1L Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus HSPA1L RGD RGD:1595925
Mus musculus HSPA1L MGD MGI:96231
Macaca mulatta HSPA1L VGNC VGNC:81079