MAX - MYC associated factor X Gene

Also Known as bHLHd4

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 4149

About MAX

Cytogenetic location: 14q23.3 Genomic coordinates (GRCh38): 14:65,006,101-65,102,695 (from NCBI)

This gene has 20 transcripts (splice variants), 283 orthologues and is associated with 89 phenotypes. Ubiquitous expression in spleen (RPKM 18.6), lymph node (RPKM 17.0) and 25 other tissues.

Summary

The protein encoded by this gene is a member of the basic helix-loop-helix leucine zipper (bHLHZ) family of transcription factors. It is able to form homodimers and heterodimers with Other family members, which include Mad, Mxi1 and Myc. Myc is an oncoprotein implicated in cell proliferation, differentiation and Apoptosis. The homodimers and heterodimers compete for a common DNA target site (the E box) and rearrangement among these dimer forms provides a complex system of transcriptional regulation. Mutations of this gene have been reported to be associated with hereditary pheochromocytoma. A pseudogene of this gene is located on the long arm of chromosome 7. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2012]

MAX Products (29)

mRNA Protein Name
NM_001271068.2 NP_001257997.1 protein max isoform g
NM_001271069.2 NP_001257998.1 protein max isoform h
NM_001320415.2 NP_001307344.1 protein max isoform i
NM_001407094.1 NP_001394023.1 protein max isoform a
NM_001407095.1 NP_001394024.1 protein max isoform b
NM_001407096.1 NP_001394025.1 protein max isoform j
NM_001407097.1 NP_001394026.1 protein max isoform j
NM_001407098.1 NP_001394027.1 protein max isoform k
NM_001407099.1 NP_001394028.1 protein max isoform l
NM_001407100.1 NP_001394029.1 protein max isoform l
NM_001407101.1 NP_001394030.1 protein max isoform l
NM_001407102.1 NP_001394031.1 protein max isoform l
NM_001407103.1 NP_001394032.1 protein max isoform c
NM_001407104.1 NP_001394033.1 protein max isoform c
NM_001407105.1 NP_001394034.1 protein max isoform i
NM_001407106.1 NP_001394035.1 protein max isoform i
NM_001407107.1 NP_001394036.1 protein max isoform i
NM_001407108.1 NP_001394037.1 protein max isoform m
NM_001407109.1 NP_001394038.1 protein max isoform m
NM_001407110.1 NP_001394039.1 protein max isoform m
NM_001407111.1 NP_001394040.1 protein max isoform n
NM_001407112.1 NP_001394041.1 protein max isoform n
NM_001407113.1 NP_001394042.1 protein max isoform g
NM_001407114.1 NP_001394043.1 protein max isoform o
NM_002382.5 NP_002373.3 protein max isoform a
NM_145112.3 NP_660087.1 protein max isoform b
NM_145113.3 NP_660088.1 protein max isoform c
NM_145114.3 NP_660089.1 protein max isoform d
NM_197957.4 NP_932061.1 protein max isoform f
Molecular Function GO Annotation Evidence References Source
enables DNA binding IDA
IDA: Inferred from direct assay
9399572 GOA
enables DNA-binding transcription factor activity, RNA polymerase II-specific IDA
IDA: Inferred from direct assay
8425218 GOA
enables DNA-binding transcription factor binding IPI
IPI: Inferred from physical interaction
15674325 GOA
contributes to DNA-binding transcription repressor activity, RNA polymerase II-specific IDA
IDA: Inferred from direct assay
8521822 GOA
enables DNA-binding transcription repressor activity, RNA polymerase II-specific IDA
IDA: Inferred from direct assay
26070438 GOA
enables E-box binding IMP
IMP: Inferred from mutant phenotype
16171389 GOA
contributes to RNA polymerase II transcription regulatory region sequence-specific DNA binding IDA
IDA: Inferred from direct assay
8425219 GOA
enables identical protein binding IPI
IPI: Inferred from physical interaction
9184233 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
9184233 GOA
enables sequence-specific double-stranded DNA binding IDA
IDA: Inferred from direct assay
28473536 GOA
Biological Process GO Annotation Evidence References Source
involved in negative regulation of transcription by RNA polymerase II IDA
IDA: Inferred from direct assay
8521822 GOA
involved in positive regulation of DNA-templated transcription IDA
IDA: Inferred from direct assay
8425218 GOA
involved in regulation of transcription by RNA polymerase II IDA
IDA: Inferred from direct assay
8425218 GOA
Cellular Component GO Annotation Evidence References Source
part of MLL1 complex IDA
IDA: Inferred from direct assay
15960975 GOA
part of Mad-Max complex IPI
IPI: Inferred from physical interaction
12553908 GOA
part of Myc-Max complex IPI
IPI: Inferred from physical interaction
12553908 GOA
part of RNA polymerase II transcription regulator complex IDA
IDA: Inferred from direct assay
8425219 GOA
located in chromatin IDA
IDA: Inferred from direct assay
12837246 GOA
located in nucleus IDA
IDA: Inferred from direct assay
10723141 GOA
part of protein-DNA complex IDA
IDA: Inferred from direct assay
9399572 GOA
part of protein-DNA complex IMP
IMP: Inferred from mutant phenotype
16171389 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

MAX Protein Structure

HLH

HLH: Helix-loop-helix DNA-binding domain (24 - 74)

  • 0
  • 100
  • 160 a.a.
Protein Preferred Names Protein Names

protein max

  • class D basic helix-loop-helix protein 4

MAX Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
MAX P61244 UNC45A Homo sapiens Q9H3U1 31515488
Intra
MAX P61244 UNC45A Homo sapiens Q9H3U1 25416956
Intra
MAX P61244 VRK3 Homo sapiens Q8IV63
TAP
25609649
Intra
MAX P61244 MECP2 Homo sapiens P51608
TAP
25609649
Intra
MAX P61244 LIG3 Homo sapiens P49916
TAP
25609649
Intra
MAX P61244 FOXK2 Homo sapiens Q01167 25609649
Intra
MAX P61244 FOXK2 Homo sapiens Q01167
TAP
25609649
Intra
MAX P61244 MGA Homo sapiens Q8IWI9
TAP
27705803
Intra
MAX P61244 MGA Homo sapiens Q8IWI9 33961781
Intra
MAX P61244 MGA Homo sapiens Q8IWI9
TAP
25609649
Intra
MAX P61244 MGA Homo sapiens Q8IWI9
Y2H
21988832
Intra
MAX P61244 MGA Homo sapiens Q8IWI9
TAP
24981860
Intra
MAX P61244 MACROH2A1 Homo sapiens O75367
TAP
25609649
Intra
MAX P61244 TFAP2A Homo sapiens P05549
TAP
25609649
Intra
MAX P61244 EEF1D Homo sapiens P29692
TAP
25609649
Intra
MAX P61244 MYC Homo sapiens P01106 32296183
Intra
MAX P61244 MYC Homo sapiens P01106
PLA
24951594
Intra
MAX P61244 MYC Homo sapiens P01106 17418410
Intra
MAX P61244 MYC Homo sapiens P01106 20691906
Intra
MAX P61244 MYC Homo sapiens P01106 32296183
Intra
MAX P61244 MYC Homo sapiens P01106 33961781
Intra
MAX P61244 MYC Homo sapiens P01106 9184233
Intra
MAX P61244 MYC Homo sapiens P01106
TAP
27705803
Intra
MAX P61244 MYC Homo sapiens P01106
PLA
18620061
Intra
MAX P61244 MYC Homo sapiens P01106
Y2H
21988832
Intra
MAX P61244 MYC Homo sapiens P01106 20691906
Intra
MAX P61244 MYC Homo sapiens P01106
TAP
25609649
Intra
MAX P61244 MYC Homo sapiens P01106 12821782
Intra
MAX P61244 MYC Homo sapiens P01106 17157259
Intra
MAX P61244 L3MBTL2 Homo sapiens Q969R5 33961781
Intra
MAX P61244 L3MBTL2 Homo sapiens Q969R5
TAP
25609649
Intra
MAX P61244 L3MBTL2 Homo sapiens Q969R5
TAP
27705803
Intra
MAX P61244 PLEKHF2 Homo sapiens Q9H8W4 16189514
Intra
MAX P61244 PLEKHF2 Homo sapiens Q9H8W4 32296183
Intra
MAX P61244 PLEKHF2 Homo sapiens Q9H8W4 32296183
Intra
MAX P61244 PLEKHF2 Homo sapiens Q9H8W4 32296183
Intra
MAX P61244 E2F6 Homo sapiens O75461
TAP
27705803
Intra
MAX P61244 E2F6 Homo sapiens O75461 33961781
Intra
MAX P61244 E2F6 Homo sapiens O75461
TAP
25609649
Intra
MAX P61244 TFDP1 Homo sapiens Q14186
TAP
25609649
Intra
MAX P61244 TFDP1 Homo sapiens Q14186 33961781
Intra
MAX P61244 TFDP1 Homo sapiens Q14186
TAP
27705803
Intra
MAX P61244 MXI1 Homo sapiens P50539 25416956
Intra
MAX P61244 MXI1 Homo sapiens P50539 25416956
Intra
MAX P61244 MXI1 Homo sapiens P50539 25416956
Intra
MAX P61244 MXI1 Homo sapiens P50539
TAP
27705803
Intra
MAX P61244 MXI1 Homo sapiens P50539 33961781
Intra
MAX P61244 MXI1 Homo sapiens P50539 9184233
Intra
MAX P61244 MXI1 Homo sapiens P50539 16189514
Intra
MAX P61244 MXI1 Homo sapiens P50539
TAP
25609649
Intra
MAX P61244 MNT Homo sapiens Q99583 33961781
Intra
MAX P61244 MNT Homo sapiens Q99583
TAP
25609649
Intra
MAX P61244 MNT Homo sapiens Q99583
TAP
27705803
Intra
MAX P61244 MNT Homo sapiens Q99583 9184233
Intra
MAX P61244 MXD1 Homo sapiens Q05195
TAP
27705803
Intra
MAX P61244 MXD1 Homo sapiens Q05195 33961781
Intra
MAX P61244 XRCC1 Homo sapiens P18887
TAP
25609649
Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant MAX Proteins

Cat. No. 상품명 Accession Purity
HY-P70388 MAX Protein, Human (His) P61244-2 (M1-S151) ≥ 95%, as determined by reducing SDS-PAGE.
HY-P73832 MAX Protein, Human (sf9, His-GST) P61244-1/NP_002373 (M1-S160) ≥ 85%, as determined by reducing SDS-PAGE.

Related Diseases

Diseases Alias
Hereditary Paraganglioma-Pheochromocytoma Syndromes
  • Hereditary Pheochromocytoma-Paraganglioma

  • Hereditary Paraganglioma-Pheochromocytoma

  • Familial Pheochromocytoma-Paraganglioma

  • Paragangliomas 2

  • Paragangliomas 3

  • Paragangliomas 4

  • Sdhx-Related Paraganglioma-Pheochromocytoma

  • Familial Paraganglioma Syndrome

  • Familial Paraganglioma-Pheochromocytoma Syndromes

  • Fpgl

  • Fpgl/Pheo

  • Paragangliomas 1

  • Paraganglioma

Pheochromocytoma
  • Pheochromocytoma, Susceptibility To

  • Phaeochromocytoma

  • Adrenal Gland Chromaffin Paraganglioma

  • Adrenal Gland Chromaffinoma

  • Adrenal Gland Paraganglioma

  • Adrenal Gland Pheochromocytoma

  • Chromaffin Paraganglioma Of The Adrenal Gland

  • Intraadrenal Paraganglioma

  • PCC

  • Chromaffin Cell Tumor

  • Medullary Chromaffinoma

  • Medullary Paraganglioma

  • Pheochromoblastoma

  • Pheochromocytomas

  • Chromaffin Cell Neoplasm

  • Pheochromocytoma, Malignant

Bap1 Tumor Predisposition Syndrome
  • Bap1-Related Tumor Predisposition Syndrome

  • Common Syndrome

  • Bap1 Cancer Syndrome

  • Bap1-Tpds

  • Cutaneous/Ocular Melanoma, Atypical Melanocytic Proliferations, And Other Internal Neoplasms

  • Tumor Predisposition Syndrome

  • Tumor Susceptibility Linked To Germline Bap1 Mutations

  • Cutaneous/Ocular Melanoma, Atypical Melanocytic Proliferations, Other Internal Neoplasms

  • Tumor Predisposition

Inherited Cancer-Predisposing Syndrome
  • Hereditary Cancer-Predisposing Syndrome

Paraganglioma
  • Chemodectoma

  • Glomus Body Tumor

  • Paragangliomas

  • Carotid Body Paraganglioma

  • Extra-Adrenal Paraganglioma

Spastic Paraplegia 84, Autosomal Recessive
  • SPG84

  • Hereditary Spastic Paraplegia 84

  • Spastic Paraplegia 84 Autosomal Recessive

  • Doid:0112347

Spastic Paraplegia 85, Autosomal Recessive
  • SPG85

  • Hereditary Spastic Paraplegia 85

  • Spastic Paraplegia 85 Autosomal Recessive

  • Doid:0112345

Spastic Paraplegia 86, Autosomal Recessive
  • SPG86

  • Hereditary Spastic Paraplegia 86

  • Spastic Paraplegia 86 Autosomal Recessive

  • Doid:0112342

Esophagus Leiomyoma
  • Leiomyoma Of Esophagus

Persistent Generalized Lymphadenopathy
  • Pgl

  • Persistant Generalized Lymphadenopathy

Multiple Endocrine Neoplasia, Type Iia
  • Multiple Endocrine Neoplasia Type 2a

  • Sipple Syndrome

  • Multiple Endocrine Neoplasia Type 2

  • MEN2A

  • Men2

  • Ptc Syndrome

  • Multiple Endocrine Neoplasia, Type 2

  • Multiple Endocrine Neoplasia Iia

  • Men 2a

  • Pheochromocytoma And Amyloid Producing Medullary Thyroid Carcinoma

  • Multiple Endocrine Neoplasia, Type 2a

  • Pheochromocytoma And Amyloid-Producing Medullary Thyroid Carcinoma

  • Multiple Endocrine Neoplasia Ii

  • Men2 Syndrome

  • Men-2a Syndrome

  • Multiple Neoplasia 2a

  • Multiple Neoplasia Type 2

Duodenal Somatostatinoma
  • Duodenal Delta Cell Somatostatin Producing Tumor

  • Duodenal Somatostatin-Producing Neuroendocrine Tumor

Sweeney-Cox Syndrome
  • SWCOS

Malignant Pheochromocytoma
  • Pheochromocytoma, Malignant

Adrenal Medulla Cancer
  • Adrenal Medulla Neoplasm

  • Adrenal Medulla Tumor

  • Malignant Neoplasm Of Adrenal Medulla

  • Malignant Tumor Of The Adrenal Medulla

  • Adrenal Medulla Carcinoma

  • Neoplasm Of Adrenal Medulla

Peripheral Nervous System Benign Neoplasm
Autonomic Nervous System Benign Neoplasm
Lung Cancer
  • Lung Carcinoma

  • Non-Small Cell Lung Carcinoma

  • Lung Cancer, Susceptibility To

  • Lung Cancer, Protection Against

  • Adenocarcinoma Of Lung, Somatic

  • Adenocarcinoma Of Lung, Response To Tyrosine Kinase Inhibitor In

  • Nonsmall Cell Lung Cancer

  • Lung Neoplasm

  • Carcinoma Of Lung

  • Lung Non-Small Cell Carcinoma

  • Non-Small Cell Lung Cancer

  • Nsclc

  • Lung Neoplasms

  • Malignant Neoplasm Of Lung

  • Alveolar Cell Carcinoma

  • Nonsmall Cell Lung Cancer, Somatic

  • Nonsmall Cell Lung Cancer, Response To Tyrosine Kinase Inhibitor In

  • Nonsmall Cell Lung Cancer, Susceptibility To

  • Lung Cancer, Somatic

  • Lung Cancer, Resistance To

  • Cancer Of Lung

  • Cancer Of Bronchus

  • Cancer Of The Lung

  • Lung Malignancies

  • Lung Malignant Tumors

  • Malignant Lung Tumor

  • Malignant Tumor Of Lung

  • Pulmonary Cancer

  • Pulmonary Carcinoma

  • Pulmonary Neoplasms

  • Respiratory Carcinoma

  • LNCR

  • Adenocarcinoma Of Lung

  • Neoplasm Of Lung

  • Cancer Lung

  • Carcinoma Non-Small Cell Lung

  • Carcinoma, Non-Small-Cell Lung

  • Lung Cancers

  • Lung Carcinomas

  • Cancer, Lung

  • Cancer, Lung, Non-Small Cell

  • Primary Malignant Neoplasm Of Lung

  • Bronchioloalveolar Adenocarcinoma

Paraganglioma And Gastric Stromal Sarcoma
  • Carney-Stratakis Syndrome

  • Paraganglioma And Gastrointestinal Stromal Tumor

  • Carney Dyad

  • Carney-Stratakis Dyad Of Paraganglioma And Gastric Stromal Sarcoma

  • Paraganglioma And Gist

  • Carney-Stratakis Dyad

  • Gist-Paraganglioma Dyad

  • PGGSS

  • Paraganglioma, Gastric Stromal Sarcoma

  • Gastrointestinal Stromal Tumors

Von Hippel-Lindau Syndrome
  • Von Hippel-Lindau Disease

  • Vhl

  • Vhl Syndrome

  • VHLS

  • Von Hippel-Lindau Syndrome, Modifier Of

  • Hippel Lindau Syndrome

  • Angiomatosis Retinae

  • Cerebelloretinal Angiomatosis, Familial

  • Hippel-Lindau Disease

  • Familial Cerebelloretinal Angiomatosis

  • Lindau Disease

  • VHLD

Williams-Beuren Syndrome
  • Williams Syndrome

  • WBS

  • Wms

  • Deletion 7q11.23

  • Monosomy 7q11.23

  • Chromosome 7q11.23 Deletion Syndrome, 1.5- To 1.8-Mb

  • Fanconi Schlesinger Syndrome

  • Beuren Syndrome

  • Elfin Facies Syndrome

  • Elfin Facies With Hypercalcemia

  • Hypercalcemia-Supravalvar Aortic Stenosis

  • Ws

Neurofibromatosis, Type I
  • Von Recklinghausen Disease

  • Neurofibromatosis 1

  • Neurofibromatosis, Type 1

  • NF1

  • Neurofibromatosis, Peripheral Type

  • Neurofibromatosis Type I

  • Neurofibromatosis Type 1 Due To Nf1 Mutation Or Intragenic Deletion

  • Familial Spinal Neurofibromatosis

  • Fsnf

  • Peripheral Neurofibromatosis

  • Von Recklinghausen'S Neurofibromatosis

  • Von Recklinghausen Disease Due To Nf1 Mutation Or Intragenic Deletion

  • Neurofibromatosis Peripheral Type

  • Von Recklinghausen Syndrome

  • Neurofibromatosis Type 1

  • Von Recklinghausen Neuropathy

  • Nf1 - [Neurofibromatosis Type 1]

  • Recklinghausen Disease

Neuroblastoma
  • Nb

  • Neuroblastoma, Susceptibility To

  • Neuroblastomas

  • Central Neuroblastoma

Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Orthologs Information

Species Symbol Source ID
Macaca mulatta MAX VGNC VGNC:74667
Rattus norvegicus MAX RGD RGD:621101
Felis catus MAX VGNC VGNC:80920
Canis familiaris MAX VGNC VGNC:43045
Mus musculus MAX MGD MGI:96921
Bos taurus MAX VGNC VGNC:31269
Others MAX NCBI