MIF4GD - MIF4G domain containing Gene

Also Known as MIFD; AD023; SLIP1

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 57409

Summary

This gene encodes a protein which interacts with the N-terminus of the stem-loop binding protein (SLBP) and the 3' end of histone mRNA. This interaction facilitates the activation of histone mRNA translation. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jun 2011]
Ubiquitous expression in lymph node (RPKM 9.4), bone marrow (RPKM 8.3) and 25 other tissues.

MIF4GD Products (12)

mRNA Protein Name
NM_001242498.2 NP_001229427.1 MIF4G domain-containing protein isoform 1
NM_001242500.1 NP_001229429.1 MIF4G domain-containing protein isoform 2
NM_001242501.1 NP_001229430.1 MIF4G domain-containing protein isoform 4
NM_001363806.2 NP_001350735.1 MIF4G domain-containing protein isoform 5
NM_001365751.1 NP_001352680.1 MIF4G domain-containing protein isoform 1
NM_001365752.1 NP_001352681.1 MIF4G domain-containing protein isoform 4
NM_001365753.1 NP_001352682.1 MIF4G domain-containing protein isoform 4
NM_001365754.1 NP_001352683.1 MIF4G domain-containing protein isoform 4
NM_001365755.1 NP_001352684.1 MIF4G domain-containing protein isoform 4
NM_001370592.1 NP_001357521.1 MIF4G domain-containing protein isoform 4
NM_001411093.1 NP_001398022.1 MIF4G domain-containing protein isoform 6
NM_020679.4 NP_065730.2 MIF4G domain-containing protein isoform 2

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables identical protein binding IPI
IPI: Inferred from physical interaction
23286197 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
16189514 GOA
Biological Process GO Annotation Evidence References Source
involved in cap-dependent translational initiation IDA
IDA: Inferred from direct assay
18025107 GOA
Cellular Component GO Annotation Evidence References Source
part of histone mRNA stem-loop binding complex IPI
IPI: Inferred from physical interaction
23286197 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

MIF4GD Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
MIF4GD A9UHW6 PDE4DIP Homo sapiens Q5VU43
Validated Y2H
25416956
Intra
MIF4GD A9UHW6 PDE4DIP Homo sapiens Q5VU43
Y2H Prey Pooling
25416956
Cross
MIF4GD A9UHW6 P0C6X7-PRO_0000037314 Human SARS coronavirus P0C6X7-PRO_0000037314
Lumier
22046132
Cross
MIF4GD A9UHW6 P0C6X7-PRO_0000037314 Human SARS coronavirus P0C6X7-PRO_0000037314
Y2H Pooling
22046132
Intra
MIF4GD A9UHW6 SLBP Homo sapiens Q14493
Solution Sedimentation
23286197
Intra
MIF4GD A9UHW6 SLBP Homo sapiens Q14493
Pull Down
23804756
Intra
MIF4GD A9UHW6 SLBP Homo sapiens Q14493
GMS
23286197
Intra
MIF4GD A9UHW6 SLBP Homo sapiens Q14493
SPR
23286197
Intra
MIF4GD A9UHW6 SLBP Homo sapiens Q14493
CD
23286197
Intra
MIF4GD A9UHW6 SLBP Homo sapiens Q14493
AFM
23286197
Intra
MIF4GD A9UHW6 SLBP Homo sapiens Q14493
NMR
23286197
Intra
MIF4GD A9UHW6 HDAC4 Homo sapiens P56524
Y2H
21988832
Intra
MIF4GD A9UHW6 HDAC4 Homo sapiens P56524
Anti Tag CoIP
21988832
Intra
MIF4GD A9UHW6 EIF3G Homo sapiens O75821
Y2H
23804756
Intra
MIF4GD A9UHW6 EIF3G Homo sapiens O75821
Pull Down
23804756
Intra
MIF4GD A9UHW6 DDX19B Homo sapiens Q9UMR2
Y2H Prey Pooling
25416956
Intra
MIF4GD A9UHW6 DDX19A Homo sapiens Q9NUU7
MAPPIT
25416956
Intra
MIF4GD A9UHW6 DDX19B Homo sapiens Q9UMR2
Y2H
23804756
Intra
MIF4GD A9UHW6 DDX19A Homo sapiens Q9NUU7
Y2H Prey Pooling
25416956
Intra
MIF4GD A9UHW6 DDX19B Homo sapiens Q9UMR2
Validated Y2H
25416956
Intra
MIF4GD A9UHW6 DDX19B Homo sapiens Q9UMR2
Anti Tag CoIP
33961781
Intra
MIF4GD A9UHW6 DDX19B Homo sapiens Q9UMR2
Pull Down
23804756
Intra
MIF4GD A9UHW6 DDX19B Homo sapiens Q9UMR2
Y2H Array
25416956
Intra
MIF4GD A9UHW6 MYC Homo sapiens P01106
Y2H
23804756
Intra
MIF4GD A9UHW6 MYC Homo sapiens P01106
Pull Down
23804756
Intra
MIF4GD A9UHW6 ERI1 Homo sapiens Q8IV48
Pull Down
23804756
Intra
MIF4GD A9UHW6 ERI1 Homo sapiens Q8IV48
Y2H
23804756
Intra
MIF4GD A9UHW6 HGS Homo sapiens O14964
Validated Y2H
25416956
Intra
MIF4GD A9UHW6 HGS Homo sapiens O14964
Y2H Array
25416956
Intra
MIF4GD A9UHW6 HGS Homo sapiens O14964
Y2H Prey Pooling
25416956
Cross: Cross-species interaction Intra: Intraspecies interaction