LRP8 - LDL receptor related protein 8 Gene
Also Known as MCI1; LRP-8; APOER2; HSZ75190
Species: Homo sapiens
About LRP8
This gene has 36 transcripts (splice variants), 286 orthologues, 14 paralogues and is associated with 1 phenotype. Biased expression in thyroid (RPKM 23.6), testis (RPKM 14.4) and 4 other tissues.
Summary
This gene encodes a member of the low density lipoprotein receptor (LDLR) family. Low density lipoprotein receptors are cell surface proteins that play roles in both signal transduction and receptor-mediated endocytosis of specific ligands for lysosomal degradation. The encoded protein plays a critical role in the migration of neurons during development by mediating Reelin signaling, and also functions as a receptor for the Cholesterol transport protein Apolipoprotein E. Expression of this gene may be a marker for major depressive disorder. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jun 2011]
LRP8 Products (4)
| mRNA | Protein | Name |
|---|---|---|
| NM_001018054.3 | NP_001018064.1 | low-density lipoprotein receptor-related protein 8 isoform 4 precursor |
| NM_004631.5 | NP_004622.2 | low-density lipoprotein receptor-related protein 8 isoform 1 precursor |
| NM_017522.5 | NP_059992.3 | low-density lipoprotein receptor-related protein 8 isoform 3 precursor |
| NM_033300.4 | NP_150643.2 | low-density lipoprotein receptor-related protein 8 isoform 2 precursor |
| Molecular Function GO Annotation | Evidence | References | Source |
|---|---|---|---|
| enables protein binding |
IPI
IPI: Inferred from physical interaction
|
12950167 | GOA |
| enables very-low-density lipoprotein particle receptor activity |
IDA
IDA: Inferred from direct assay
|
8626535 | GOA |
| Biological Process GO Annotation | Evidence | References | Source |
|---|---|---|---|
| involved in endocytosis |
IDA
IDA: Inferred from direct assay
|
8626535 | GOA |
| Cellular Component GO Annotation | Evidence | References | Source |
|---|---|---|---|
| located in caveola |
IDA
IDA: Inferred from direct assay
|
11369809 | GOA |
| is active in plasma membrane |
IDA
IDA: Inferred from direct assay
|
30873003 | GOA |
| part of receptor complex |
IDA
IDA: Inferred from direct assay
|
23382219 | GOA |
LRP8 Protein Structure
Ldl_recept_a: Low-density lipoprotein receptor domain class A (46 - 81)
Ldl_recept_a: Low-density lipoprotein receptor domain class A (84 - 122)
Ldl_recept_a: Low-density lipoprotein receptor domain class A (127 - 163)
Ldl_recept_a: Low-density lipoprotein receptor domain class A (167 - 201)
Ldl_recept_a: Low-density lipoprotein receptor domain class A (204 - 243)
Ldl_recept_a: Low-density lipoprotein receptor domain class A (259 - 294)
Ldl_recept_a: Low-density lipoprotein receptor domain class A (298 - 333)
FXa_inhibition: Coagulation Factor Xa inhibitory site (340 - 374)
EGF_CA: Calcium-binding EGF domain (376 - 414)
Ldl_recept_b: Low-density lipoprotein receptor repeat class B (462 - 506)
Ldl_recept_b: Low-density lipoprotein receptor repeat class B (510 - 549)
Ldl_recept_b: Low-density lipoprotein receptor repeat class B (552 - 592)
Ldl_recept_b: Low-density lipoprotein receptor repeat class B (596 - 637)
Ldl_recept_b: Low-density lipoprotein receptor repeat class B (639 - 679)
- 0
- 200
- 400
- 600
- 800
- 963 a.a.
| Protein Preferred Names | Protein Names | |
|---|---|---|
|
low-density lipoprotein receptor-related protein 8 |
|
LRP8 Protein-protein interaction Information
|
Type
|
Protein Name | Protein ID | Interactor | Interactor Species | Interactor ID | Detection Method | References |
|---|---|---|---|---|---|---|---|
|
Intra
|
LRP8 | Q14114 | APC | Homo sapiens | P25054 | 19116273 | |
|
Intra
|
LRP8 | Q14114 | APC | Homo sapiens | P25054 | 19116273 | |
|
Cross
|
LRP8 | Q14114 | Reln | Mus musculus | Q60841 | 20223215 |
LRP8 Antibodies
| Cat. No. | 상품명 | 신청 | Reactivity |
|---|---|---|---|
| HY-P81771 | ApoE Antibody (YA1516) | WB, IHC-P, ICC/IF, IP | Human, Mouse |
| HY-P81771A | ApoE Antibody (YA1516)(PBS only) | WB, IHC-P, ICC/IF, IP | Human, Mouse |
| HY-P82383 | ApoER2 Antibody (YA2128) | WB, IP | Human, Rat, Hamster |
| HY-P82383A | ApoER2 Antibody (YA2128)(PBS only) | WB, IP | Human, Rat, Hamster |
| HY-P84562 | ApoER2 Antibody (YA4259) | FC, ELISA | Human |
| HY-P84562A | ApoER2 Antibody (YA4259)(PBS only) | FC, ELISA | Human |
Related Diseases
| Diseases | Alias | |
|---|---|---|
| Myocardial Infarction |
|
|
| Osteoporosis-Pseudoglioma Syndrome |
|
|
| Lissencephaly |
|
|
| Cerebellar Hypoplasia |
|
|
| Major Depressive Disorder |
|
|
| Lissencephaly 2 |
|
|
| Donnai-Barrow Syndrome |
|
|
| Spinocerebellar Ataxia 37 |
|
|
| Bartter Syndrome, Type 4a, Neonatal, With Sensorineural Deafness |
|
|
| Alzheimer Disease, Familial, 1 |
|
|
| Schizophrenia |
|
|
| Congenital Nervous System Abnormality |
|
Orthologs Information
| Species | Symbol | Source | ID |
|---|---|---|---|
| Felis catus | LRP8 | VGNC | VGNC:68092 |
| Macaca mulatta | LRP8 | VGNC | VGNC:74447 |
| Bos taurus | LRP8 | VGNC | VGNC:30994 |
| Canis familiaris | LRP8 | VGNC | VGNC:42779 |
| Rattus norvegicus | LRP8 | RGD | RGD:1305729 |
| Mus musculus | LRP8 | MGD | MGI:1340044 |
| Others | LRP8 | NCBI |