Grm7 - glutamate metabotropic receptor 7 Gene

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 81672

About Grm7

Primary_assembly 4: 143,731,259-144,612,344 forward strand.mRatBN7.2:CM026977.1

This gene has 2 transcripts (splice variants), 280 orthologues, 7 paralogues and is associated with 7 phenotypes. Restricted expression toward (RPKM 123.2).

Summary

Enables several functions, including PDZ domain binding activity; Calmodulin binding activity; and glutamate binding activity. Involved in adenylate cyclase-inhibiting G protein-coupled glutamate receptor signaling pathway; negative regulation of glutamate secretion; and negative regulation of neuron apoptotic process. Located in several cellular components, including dendritic shaft; rough endoplasmic reticulum; and synaptic membrane. Part of protein-containing complex. Is active in GABA-ergic synapse and glutamatergic synapse. Is integral component of presynaptic active zone membrane. Orthologous to human GRM7 (glutamate metabotropic receptor 7). [provided by Alliance of Genome Resources, Apr 2022]

Grm7 Products (1)

mRNA Protein Name
NM_031040.1 NP_112302.1 metabotropic glutamate receptor 7 precursor

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables PDZ domain binding IPI
IPI: Inferred from physical interaction
11007882 RGD
enables adenylate cyclase inhibiting G protein-coupled glutamate receptor activity IDA
IDA: Inferred from direct assay
11825890 RGD
enables calcium-dependent protein binding IPI
IPI: Inferred from physical interaction
21855531 RGD
enables calmodulin binding IPI
IPI: Inferred from physical interaction
12021391 RGD
enables glutamate binding IDA
IDA: Inferred from direct assay
11825890 RGD
enables group III metabotropic glutamate receptor activity IDA
IDA: Inferred from direct assay
12692128 RGD
enables identical protein binding IPI
IPI: Inferred from physical interaction
17620729 RGD
enables protein binding IPI
IPI: Inferred from physical interaction
11891216 RGD
Biological Process GO Annotation Evidence References Source
involved in adenylate cyclase-inhibiting G protein-coupled glutamate receptor signaling pathway IDA
IDA: Inferred from direct assay
11825890 RGD
involved in negative regulation of glutamate secretion IDA
IDA: Inferred from direct assay
11825890 RGD
involved in negative regulation of neuron apoptotic process IDA
IDA: Inferred from direct assay
26621121 RGD
Cellular Component GO Annotation Evidence References Source
is active in GABA-ergic synapse IDA
IDA: Inferred from direct assay
9295396 RGD
located in asymmetric synapse IDA
IDA: Inferred from direct assay
9300765 RGD
located in axon IDA
IDA: Inferred from direct assay
9300765 RGD
located in axon terminus IDA
IDA: Inferred from direct assay
11825890 RGD
located in cell surface IDA
IDA: Inferred from direct assay
16890965 RGD
located in dendrite IDA
IDA: Inferred from direct assay
9300765 RGD
located in dendritic shaft IDA
IDA: Inferred from direct assay
12823458 RGD
is active in glutamatergic synapse IDA
IDA: Inferred from direct assay
8604049 RGD
located in neuronal cell body IDA
IDA: Inferred from direct assay
8929965 RGD
located in postsynaptic membrane IDA
IDA: Inferred from direct assay
8764662 RGD
located in presynaptic active zone IDA
IDA: Inferred from direct assay
8764662 RGD
is active in presynaptic active zone membrane IDA
IDA: Inferred from direct assay
9295396 RGD
is active in presynaptic active zone membrane IMP
IMP: Inferred from mutant phenotype
35511883 RGD
is active in presynaptic membrane IDA
IDA: Inferred from direct assay
8604049 RGD
located in presynaptic membrane IDA
IDA: Inferred from direct assay
9300765 RGD
part of protein-containing complex IDA
IDA: Inferred from direct assay
11007882 RGD
located in terminal bouton IDA
IDA: Inferred from direct assay
12823458 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Grm7 Protein Structure

PBP1_mGluR_groupIII

PBP1_mGluR_groupIII: cd06376 (42 - 510)

NCD3G

NCD3G: pfam07562 (518 - 568)

7tmC_mGluR7

7tmC_mGluR7: cd15451 (588 - 613)

7tmC_mGluR7

7tmC_mGluR7: cd15451 (588 - 894)

7tmC_mGluR7

7tmC_mGluR7: cd15451 (625 - 646)

7tmC_mGluR7

7tmC_mGluR7: cd15451 (655 - 679)

7tmC_mGluR7

7tmC_mGluR7: cd15451 (701 - 721)

7tmC_mGluR7

7tmC_mGluR7: cd15451 (751 - 777)

7tmC_mGluR7

7tmC_mGluR7: cd15451 (785 - 808)

7tmC_mGluR7

7tmC_mGluR7: cd15451 (818 - 843)

  • 0
  • 200
  • 400
  • 600
  • 800
  • 922 a.a.
Protein Preferred Names Protein Names

metabotropic glutamate receptor 7

  • glutamate receptor, metabotropic 7

  • mGluR7

  • metabotropic glutamate receptor mGluR7

  • metabotropic glutamate receptor subtype 7b

Grm7 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
Grm7 P35400 Pick1 Rattus norvegicus Q9EP80
Pull Down
11891216
Intra
Grm7 P35400 Pick1 Rattus norvegicus Q9EP80
Anti Tag CoIP
11007882
Intra
Grm7 P35400 Pick1 Rattus norvegicus Q9EP80
Y2H Array
11007882
Intra
Grm7 P35400 Pick1 Rattus norvegicus Q9EP80
Y2H
11891216
Intra
Grm7 P35400 Pick1 Rattus norvegicus Q9EP80
Pull Down
11007882
Intra
Grm7 P35400 Ppp1cc Rattus norvegicus P63088
Y2H
14519764
Intra
Grm7 P35400 Grip1 Rattus norvegicus P97879
Pull Down
11891216
Intra
Grm7 P35400 Grip1 Rattus norvegicus P97879
Imaging
11891216
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. 상품명
효과
Purity
Rare Diseases
HY-RS05837 GRM7 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS05838 Grm7 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS05839 Grm7 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Grm7 NCBI NCBI:2917