H3-4 - H3.4 histone, cluster member Gene

Also Known as H3t; H3.4; H3/g; H3FT; H3C16; HIST3H3

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 8290

About H3-4

Cytogenetic location: 1q42.13 Genomic coordinates (GRCh38): 1:228,424,845-228,425,360 (from NCBI)

This gene has 1 transcript (splice variant), 1 gene allele, 115 orthologues, 20 paralogues and is associated with 1 phenotype.

Summary

Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Nucleosomes consist of approximately 146 bp of DNA wrapped around a histone octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. This gene is intronless and encodes a replication-dependent histone that is a member of the histone H3 family. Transcripts from this gene lack polyA tails; instead, they contain a palindromic termination element. This gene is located separately from the Other H3 genes that are in the histone gene cluster on chromosome 6p22-p21.3. [provided by RefSeq, Aug 2015]

H3-4 Products (1)

mRNA Protein Name
NM_003493.3 NP_003484.1 histone H3.1t

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
17537733 GOA
Biological Process GO Annotation Evidence References Source
involved in nucleosome assembly IDA
IDA: Inferred from direct assay
25615412 GOA
involved in nucleosome assembly IMP
IMP: Inferred from mutant phenotype
20498094 GOA
Cellular Component GO Annotation Evidence References Source
part of nucleosome IDA
IDA: Inferred from direct assay
20498094 GOA
part of nucleosome IPI
IPI: Inferred from physical interaction
20498094 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

H3-4 Protein Structure

Histone

Histone: Core histone H2A/H2B/H3/H4 (58 - 132)

  • 0
  • 100
  • 136 a.a.
Protein Preferred Names Protein Names

histone H3.1t

  • H3 clustered histone 16

H3-4 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
H3-4 Q16695 H4C16 Homo sapiens P62805
GMS
20498094
Intra
H3-4 Q16695 H4C16 Homo sapiens P62805
DLS
20498094
Intra
H3-4 Q16695 H2AC4 Homo sapiens P04908
Crosslink
30021884
Intra
H3-4 Q16695 H2AX Homo sapiens P16104
Crosslink
30021884
Intra
H3-4 Q16695 AURKB Homo sapiens Q96GD4
Protein Kinase Assay
29340707
Intra
H3-4 Q16695 AURKB Homo sapiens Q96GD4
Anti Bait CoIP
29340707
Intra
H3-4 Q16695 NASP Homo sapiens P49321-2
Y2H Prey Pooling
32296183
Intra
H3-4 Q16695 NASP Homo sapiens P49321-2
Y2H Array
32296183
Intra
H3-4 Q16695 H3C13 Homo sapiens Q71DI3
Crosslink
30021884
Intra
H3-4 Q16695 CBX5 Homo sapiens P45973
Crosslink
30021884
Cross: Cross-species interaction Intra: Intraspecies interaction

H3-4 Antibodies

Cat. No. 상품명 신청 Reactivity
HY-P80166 Histone H3 Antibody (YA368) WB, ICC/IF, IHC-P, IP, ChIP Human, Mouse, Rat
HY-P81287 MonoMethyl-Histone H3 Antibody (YA997) WB, IHC-P Human, Mouse, Rat
HY-P81287A MonoMethyl-Histone H3 Antibody (YA998) WB, ICC/IF Human, Mouse

Related Diseases

Diseases Alias
Colon Leiomyoma

  • Colonic Leiomyoma
Male Infertility

  • Infertility, Male

  • Infertility Male

  • Male Sterility

  • Absolute Infertility
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. 상품명
효과
Purity
Rare Diseases
HY-RS05963 H3-4 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus H3-4 RGD RGD:1583877
Macaca mulatta H3-4 VGNC VGNC:109730
Mus musculus H3-4 MGD MGI:3651326
Others H3-4 NCBI