LPXN - leupaxin Gene

Also Known as LDPL

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 9404

About LPXN

Cytogenetic location: 11q12.1 Genomic coordinates (GRCh38): 11:58,526,871-58,578,891 (from NCBI)

This gene has 5 transcripts (splice variants), 202 orthologues and 2 paralogues. Broad expression in lymph node (RPKM 15.3), appendix (RPKM 9.9) and 22 other tissues.

Summary

The product encoded by this gene is preferentially expressed in hematopoietic cells and belongs to the paxillin protein family. Similar to Other members of this focal-adhesion-associated adaptor-protein family, it has four leucine-rich LD-motifs in the N-terminus and four LIM domains in the C-terminus. It may function in cell type-specific signaling by associating with Pyk2, a member of focal adhesion kinase family. As a substrate for a tyrosine kinase in lymphoid cells, this protein may also function in, and be regulated by, tyrosine kinase activity. Alternative splicing results in multiple transcript variants encoding distinct isoforms.[provided by RefSeq, Jan 2009]

LPXN Products (3)

mRNA	Protein	Name
NM_001143995.3	NP_001137467.1	leupaxin isoform 1
NM_001307951.2	NP_001294880.1	leupaxin isoform 3
NM_004811.3	NP_004802.1	leupaxin isoform 2

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	17640867	GOA
enables transcription coregulator activity	IDA IDA: Inferred from direct assay	18451096	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in negative regulation of B cell receptor signaling pathway	IDA IDA: Inferred from direct assay	17640867	GOA
involved in negative regulation of cell adhesion	IDA IDA: Inferred from direct assay	20543562	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in cytoplasm	IDA IDA: Inferred from direct assay	17640867	GOA
located in focal adhesion	IDA IDA: Inferred from direct assay	18451096	GOA
located in nucleus	IDA IDA: Inferred from direct assay	18451096	GOA
located in plasma membrane	IDA IDA: Inferred from direct assay	17640867	GOA
located in podosome	IDA IDA: Inferred from direct assay	12674328	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

LPXN Protein Structure

LIM

0
100
200
300
386 a.a.

Protein Preferred Names	Protein Names
leupaxin

LPXN Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	LPXN	O60711	RUNX1T1	Homo sapiens	Q06455-4	Validated Y2H	25416956
Intra	LPXN	O60711	RUNX1T1	Homo sapiens	Q06455-4	Y2H Prey Pooling	25416956
Intra	LPXN	O60711	PLEKHN1	Homo sapiens	Q494U1	Y2H Array	25416956
Intra	LPXN	O60711	PLEKHN1	Homo sapiens	Q494U1	Y2H Prey Pooling	25416956
Intra	LPXN	O60711	VCL	Homo sapiens	P18206-2	Validated Y2H	32296183
Intra	LPXN	O60711	LMO3	Homo sapiens	Q8TAP4-4	Validated Y2H	32296183
Intra	LPXN	O60711	POM121	Homo sapiens	Q96HA1-2	Validated Y2H	32296183
Intra	LPXN	O60711	RUNX1T1	Homo sapiens	Q06455-2	Validated Y2H	32296183
Intra	LPXN	O60711	PLEKHN1	Homo sapiens	Q494U1-3	Validated Y2H	32296183
Intra	LPXN	O60711	HOXC9	Homo sapiens	P31274	Y2H Array	31515488
Intra	LPXN	O60711	HOXC9	Homo sapiens	P31274	Validated Y2H	25416956
Intra	LPXN	O60711	HOXC9	Homo sapiens	P31274	Validated Y2H	32296183
Intra	LPXN	O60711	HOXC9	Homo sapiens	P31274	Y2H Array	25416956
Intra	LPXN	O60711	HOXC9	Homo sapiens	P31274	Y2H Prey Pooling	25416956
Intra	LPXN	O60711	PLEKHH2	Homo sapiens	Q8IVE3	Anti Tag CoIP	33961781
Intra	LPXN	O60711	PLEKHH2	Homo sapiens	Q8IVE3	Validated Y2H	25416956
Intra	LPXN	O60711	PLEKHH2	Homo sapiens	Q8IVE3	Anti Tag CoIP	28514442
Intra	LPXN	O60711	PLEKHH2	Homo sapiens	Q8IVE3	Y2H Array	25416956
Cross	LPXN	O60711	Hoxa1	Mus musculus	P09022	Y2H	23088713
Intra	LPXN	O60711	TXLNB	Homo sapiens	Q8N3L3	Y2H Array	25416956
Intra	LPXN	O60711	PTK2	Homo sapiens	Q05397	Anti Tag CoIP	28514442
Intra	LPXN	O60711	PTK2	Homo sapiens	Q05397	Anti Tag CoIP	33961781
Intra	LPXN	O60711	PTK2	Homo sapiens	Q05397	Y2H	21900206
Intra	LPXN	O60711	AGXT	Homo sapiens	P21549	Validated Y2H	32296183
Intra	LPXN	O60711	AQP1	Homo sapiens	P29972	Validated Y2H	32296183
Intra	LPXN	O60711	TGFB1	Homo sapiens	P01137	Validated Y2H	32296183
Intra	LPXN	O60711	LMO1	Homo sapiens	P25800	Validated Y2H	32296183
Intra	LPXN	O60711	TNS2	Homo sapiens	Q63HR2	Validated Y2H	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

LPXN Antibodies

Cat. No.	상품명	신청	Reactivity
HY-P89703	leupaxin Antibody (YA9047)	WB, ICC/IF, IF-Tissue, IP, ELISA	human

Related Diseases

Diseases	Alias
Cholelithiasis
Lipid Metabolism Disorder	Dyslipidemia Disorder Of Fatty Acid Metabolism Lipid Metabolism Disorders Fatty Acid Metabolism Disorder Disorder Of Lipid Metabolism Abnormality Of Lipid Metabolism Lipid Metabolism, Inborn Errors Dyslipidemias Disorders Of Lipid Metabolism Congenital Disorders Of Lipid Metabolism Inherited Disorders Of Lipid Metabolism
Type 2 Diabetes Mellitus	Insulin Resistance NIDDM Type 2 Diabetes Diabetes Mellitus, Non-Insulin-Dependent T2D Noninsulin-Dependent Diabetes Mellitus Diabetes Mellitus, Type Ii Maturity-Onset Diabetes Insulin Resistance, Severe, Digenic Diabetes Mellitus, Type 2 Diabetes Mellitus, Noninsulin-Dependent Diabetes Mellitus, Noninsulin-Dependent, Association With Diabetes Mellitus, Noninsulin-Dependent, Late Onset Hypertension, Insulin Resistance-Related, Susceptibility To Insulin Resistance, Susceptibility To Non-Insulin-Dependent Diabetes Mellitus Type Ii Diabetes Mellitus Adult-Onset Diabetes Mellitus Maturity-Onset Diabetes Mellitus Diabetes Mellitus Type 2 Type Ii Diabetes Type 2 Diabetes Mellitus, Susceptibility To Diabetes, Type 2 Diabetes Mellitus, Noninsulin-Dependent, Susceptibility To Diabetes Mellitus, Non-Insulin-Dependent, Susceptibility To Diabetes Mellitus, Type 2, Susceptibility To Diabetes Mellitus, Noninsulin-Dependent, 2 Diabetes Mellitus, Type Ii, Susceptibility To Hypertension, Insulin Resistance-Related Adult-Onset Diabetes Aodm Diabetes Mellitus, Adult-Onset Diabetes Mellitus Type Ii Diabetes Mellitus Type 2, Susceptibility To Diabetes, Type Ii, Susceptibility To Diabetes Type 2 Diabetes Mellitus Adult Onset Diabetes Maturity Onset Diabetes Nonketotic Diabetes Non-Insulin Dependent Diabetes Mellitus T2dm - [Type 2 Diabetes Mellitus] Niddm - [Non Insulin Dependent Diabetes Mellitus] Dm2 Dm Type Ii Diabetic Type 2 Insulin Requiring Type 2 Diabetes Noninsulin Dependent Diabetes Non-Insulin-Dependent Diabetes Mellitus Without Complications Diabetes Due To Insulin Secretory Defect Diabetes Mellitus Due To Insulin Secretory Defect Non-Insulin-Dependent Diabetes Of The Young Senile Diabetes Nonketotic Hyperglycaemia Stable Diabetes
Prostate Cancer	Prostate Carcinoma Prostate Cancer, Familial Prostate Neoplasm Prostate Cancer, Somatic Prostate Cancer, Susceptibility To Prostatic Cancer Prostatic Neoplasms Hereditary Prostate Cancer Prostatic Neoplasm Cancer Of Prostate Carcinoma Of Prostate Familial Prostate Cancer Familial Prostate Carcinoma Malignant Tumor Of Prostate Malignant Neoplasm Of Prostate Prostate Cancer, Familial, Susceptibility To Malignant Tumor Of The Prostate Ngp - New Growth Of Prostate Tumor Of The Prostate Prostate Cancer, Hereditary Cancer Of The Prostate Malignant Neoplasm Of The Prostate Prostatic Carcinoma PC Prca Cancer, Prostate Malignant Prostatic Tumour Malignant Tumour Of Prostate Primary Prostate Cancer Primary Malignant Neoplasm Of Prostate Prostate Gland Cancer
Diabetes Mellitus	Diabetes

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	상품명	효과	Purity	Rare Diseases
HY-RS07775	LPXN Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	LPXN	VGNC	VGNC:42756
Rattus norvegicus	LPXN	RGD	RGD:1304981
Felis catus	LPXN	VGNC	VGNC:63271
Macaca mulatta	LPXN	VGNC	VGNC:74286
Mus musculus	LPXN	MGD	MGI:2147677
Bos taurus	LPXN	VGNC	VGNC:30971
Others	LPXN	NCBI