Cat. No.: HY-117196

GW 9578

Name: GW 9578
Brand: MedChemExpress
SKU: HY-117196
Price: 70.00 USD
Availability: InStock
Rating: 5 (1 reviews)

1 Cited Publications

고객리뷰

Based on 1 publication(s) in Google Scholar

GW9578 is a subtype-selective PPARα agonist (EC₅₀s of 5 and 50 nM for murine and human PPAR-α) with potent lipid-lowering activity.

연구목적의 판매만을 진행합니다. 환자를 대상으로 한 판매는 하지 않습니다.

Purity : 99.6%
CAS No.: 247923-29-1
화학식: C₂₆H₃₄F₂N₂O₃S
분자량:492.62

보관:

Solution, -20°C, 2 years

GW 9578 Chemical Structure

CAS No.: 247923-29-1

사이즈

가격

재고

수량

Amount: USD 0.00

* 장바구니에 담기 전 물품의 수량을 선택해 주십시오.

Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- 제품 설명
- IC₅₀ & Target
- Cellular Effect
- In Vitro
Chemical Information
Publications (1)
순도&문서
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

제품 설명

GW9578 is a subtype-selective PPARα agonist (EC₅₀s of 5 and 50 nM for murine and human PPAR-α) with potent lipid-lowering activity^[1]^[2].

IC₅₀ & Target

mouse PPARα

5 nM (EC₅₀)

h-PPARα

50 nM (EC₅₀)

All PPAR Isoforms :

Cellular Effect

Cell Line	Type	Value	Description	References
CV-1	EC₅₀	0.005 μM Compound: 8	Compound was tested for its agonist activity against murine Peroxisome proliferator activated receptor alpha-Gal4 chimeric receptor transfected CV-1 cells Compound was tested for its agonist activity against murine Peroxisome proliferator activated receptor alpha-Gal4 chimeric receptor transfected CV-1 cells	[PMID: 10508427]
CV-1	EC₅₀	0.05 μM Compound: 8	Compound was tested for agonist activity on human Peroxisome proliferator activated receptor alpha-Gal4 chimeric receptor in transfected CV-1 cells Compound was tested for agonist activity on human Peroxisome proliferator activated receptor alpha-Gal4 chimeric receptor in transfected CV-1 cells	[PMID: 10508427]
CV-1	EC₅₀	1 μM Compound: 8	Compound was tested for agonist activity on human Peroxisome proliferator activated receptor gamma-Gal4 chimeric receptor in transfected CV-1 cells Compound was tested for agonist activity on human Peroxisome proliferator activated receptor gamma-Gal4 chimeric receptor in transfected CV-1 cells	[PMID: 10508427]
CV-1	EC₅₀	1.4 μM Compound: 8	Compound was tested for agonist activity on human Peroxisome proliferator activated receptor delta-GAL4 chimeric receptor in transfected CV-1 cells Compound was tested for agonist activity on human Peroxisome proliferator activated receptor delta-GAL4 chimeric receptor in transfected CV-1 cells	[PMID: 10508427]
CV-1	EC₅₀	1.5 μM Compound: 8	Compound was tested for its agonist activity against murine Peroxisome proliferator activated receptor gamma-Gal4 chimeric receptor in transfected CV-1 cells Compound was tested for its agonist activity against murine Peroxisome proliferator activated receptor gamma-Gal4 chimeric receptor in transfected CV-1 cells	[PMID: 10508427]
CV-1	EC₅₀	2.6 μM Compound: 8	Compound was tested for its agonist activity against murine Peroxisome proliferator activated receptor delta-GAL4 chimeric receptor in transfected CV-1 cells Compound was tested for its agonist activity against murine Peroxisome proliferator activated receptor delta-GAL4 chimeric receptor in transfected CV-1 cells	[PMID: 10508427]
CV-1	EC₅₀	0.05 μM Compound: GW-9578	In vitro transcriptional activation in CV-1 cells expressing human Gal4-PPAR alpha ligand binding domain In vitro transcriptional activation in CV-1 cells expressing human Gal4-PPAR alpha ligand binding domain	[PMID: 11354382]
CV-1	EC₅₀	1 μM Compound: GW-9578	In vitro transcriptional activation in CV-1 cells expressing human Gal4-PPAR gamma ligand binding domain In vitro transcriptional activation in CV-1 cells expressing human Gal4-PPAR gamma ligand binding domain	[PMID: 11354382]
CV-1	EC₅₀	1.4 μM Compound: GW-9578	In vitro transcriptional activation in CV-1 cells expressing human Gal4-PPAR delta ligand binding domain In vitro transcriptional activation in CV-1 cells expressing human Gal4-PPAR delta ligand binding domain	[PMID: 11354382]
HEK293	EC₅₀	0.15 μM Compound: GSK-9578	Agonist activity at PPARdelta expressed in HEK293 cells by GAL4 transactivation assay Agonist activity at PPARdelta expressed in HEK293 cells by GAL4 transactivation assay	[PMID: 18029176]
HEK293	EC₅₀	0.45 μM Compound: GSK-9578	Agonist activity at PPARalpha expressed in HEK293 cells by GAL4 transactivation assay Agonist activity at PPARalpha expressed in HEK293 cells by GAL4 transactivation assay	[PMID: 18029176]
HEK293	EC₅₀	0.5 μM Compound: GSK-9578	Agonist activity at PPARgamma expressed in HEK293 cells by GAL4 transactivation assay Agonist activity at PPARgamma expressed in HEK293 cells by GAL4 transactivation assay	[PMID: 18029176]
HeLa	EC₅₀	250 nM Compound: 26, GW-9578	Agonist activity at PPARalpha ligand binding domain expressed in human HeLa cells co-transfected with Gal4-DBD assessed as transcriptional activation by Gal4 response element-driven luciferase reporter gene assay Agonist activity at PPARalpha ligand binding domain expressed in human HeLa cells co-transfected with Gal4-DBD assessed as transcriptional activation by Gal4 response element-driven luciferase reporter gene assay	[PMID: 19275963]
HeLa	EC₅₀	250 nM Compound: 26, GW-9578	Agonist activity at PPARgamma ligand binding domain expressed in human HeLa cells co-transfected with Gal4-DBD assessed as transcriptional activation by Gal4 response element-driven luciferase reporter gene assay Agonist activity at PPARgamma ligand binding domain expressed in human HeLa cells co-transfected with Gal4-DBD assessed as transcriptional activation by Gal4 response element-driven luciferase reporter gene assay	[PMID: 19275963]
HeLa	EC₅₀	1 μM Compound: 26, GW-9578	Agonist activity at PPARdelta ligand binding domain expressed in human HeLa cells co-transfected with Gal4-DBD assessed as transcriptional activation by Gal4 response element-driven luciferase reporter gene assay Agonist activity at PPARdelta ligand binding domain expressed in human HeLa cells co-transfected with Gal4-DBD assessed as transcriptional activation by Gal4 response element-driven luciferase reporter gene assay	[PMID: 19275963]
HepG2	EC₅₀	78 nM Compound: gw9578	Agonist activity at human PPARalpha in HepG2 cells by PPAR-GAL4 transactivation assay Agonist activity at human PPARalpha in HepG2 cells by PPAR-GAL4 transactivation assay	[PMID: 17157019]

In Vitro

GW9578 exhibits activities on Murine PPAR-α, PPAR-γ, and PPAR-δ with EC₅₀s of 0.005, 1.5, 2.6 μm, respectively. GW9578 exhibits activities on Human PPAR-α, PPAR-γ, and PPAR-δ with EC₅₀s of 0.05, 1, and 1.4 μm, respectively^[2].
Treatment of the CD8⁺ T-cell line, TK.1 cells with GW9578 (10 nM-1 μM; for 24 hours) is able to induce a dose-dependent increase in the amount of relative luciferase activity^[3].
Treatment of murine T-cell thymoma EL-4 T cells with GW9578 (10 nM-10 μM; for 2 hours) leads to a significant decrease in IL-2 production compared with control cells^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. .

Chemical Information

CAS No. 247923-29-1
Appearance Liquid
분자량 492.62
화학식 C₂₆H₃₄F₂N₂O₃S
Color Colorless to light yellow
SMILES

CC(C)(SC1=CC=C(CCN(C(NC2=CC=C(F)C=C2F)=O)CCCCCCC)C=C1)C(O)=O
선적

Room temperature in continental US; may vary elsewhere.
보관

Solution, -20°C, 2 years

Publications (1)

All

Sort by:

Journal Impact Factor

Islets

Annexin A1 exacerbates islet stellate cell activation by regulating triglyceride catabolism via the PPARα/ACOX1/CYP4a pathway. [Abstract]

2026 Dec 31;18(1):2633793. PMID: 41723748

순도&문서

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (273 KB)
SDS (394 KB)
- English - EN (394 KB)
- Français - FR (394 KB)
- Deutsch - DE (394 KB)
- Norwegian - NO (394 KB)
- Español - ES (394 KB)
- Swedish - SV (394 KB)
- Italian - IT (394 KB)
- Korean - KR (394 KB)
- Portuguese - PT (394 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. P J Brown, et al. A ureido-thioisobutyric acid (GW9578) is a subtype-selective PPARalpha agonist with potent lipid-lowering activity. J Med Chem. 1999 Sep 23;42(19):3785-8. [Content Brief]

[2]. Alexandre Trifilieff, et al. PPAR-alpha and -gamma but not -delta agonists inhibit airway inflammation in a murine model of asthma: in vitro evidence for an NF-kappaB-independent effect. Br J Pharmacol. 2003 May;139(1):163-71. [Content Brief]

[3]. Dallas C Jones, et al. Nuclear receptor peroxisome proliferator-activated receptor alpha (PPARalpha) is expressed in resting murine lymphocytes. The PPARalpha in T and B lymphocytes is both transactivation and transrepression competent. J Biol Chem. 2002 [Content Brief]

Calculators

몰농도 계산기

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

농도 희석 계산기

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

상품명:
Cat. No.:
수량:
MCE Japan Authorized Agent:

상품명:
CAS No.:
Species:
Purity:
수량:

GW 9578

Publications Citing Use of MedChemExpress (MCE) GW 9578

All PPAR Isoforms