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Cat. No.: HY-165396

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HC103A

HC103A is an Antibacterial agent and a DosS/DosT histidine sensor kinase inhibitor, with an IC₅₀ of 0.5 μM against DosS and ~5 μM against DosT of *Mycobacterium tuberculosis*. HC103A inhibits the autophosphorylation of DosS/DosT. HC103A suppresses hypoxia-induced triacylglycerol synthesis and the viability of Mtb. HC103A can be used in the research of tuberculosis.

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CAS No.: 312595-37-2
화학식: C₁₈H₁₄N₂O₃S
분자량:338.38

보관:

Please store the product under the recommended conditions in the Certificate of Analysis.

HC103A Chemical Structure

CAS No.: 312595-37-2

Amount: USD 0.00

* 장바구니에 담기 전 물품의 수량을 선택해 주십시오.

Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- 제품 설명
- In Vitro
Chemical Information
순도&문서
References
Calculators
Help & FAQs
Classifications
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Biological Activity

제품 설명

In Vitro

HC103A (0.1-100 μM; 6 d) potently and selectively inhibits DosR-dependent GFP fluorescence in Mycobacterium tuberculosis CDC1551(hspX′::GFP) with an EC₅₀ of 2.7 μM without affecting bacterial growth^[1].
HC103A (40 μM) reduces triacylglycerol accumulation by 56% in Mycobacterium tuberculosis CDC1551, disrupting a key persistence-associated lipid metabolism pathway^[1].
HC103A (0-60 μM; 1 h) directly inhibits autophosphorylation of purified Mycobacterium tuberculosis DosS (IC₅₀ 0.5 μM) and DosT (IC₅₀ ~5 μM) sensor kinases without altering their heme redox status^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 312595-37-2
분자량 338.38
화학식 C₁₈H₁₄N₂O₃S
SMILES

O=C(NC1=CC=CC(=C1)C(=O)NC=2C=CC=C(O)C2)C=3SC=CC3
선적

Room temperature in continental US; may vary elsewhere.
보관

Please store the product under the recommended conditions in the Certificate of Analysis.

순도&문서

Handling Instructions (2659 KB)

References

[1]. Zheng H, et al. Inhibitors of Mycobacterium tuberculosis DosRST signaling and persistence. Nat Chem Biol. 2017;13(2):218-225. [Content Brief]

[2]. Zheng H, et al. Inhibiting Mycobacterium tuberculosis DosRST Signaling by Targeting Response Regulator DNA Binding and Sensor Kinase Heme. ACS Chem Biol. 2020 Jan 17;15(1):52-62. [Content Brief]

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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Keywords

MOQ

Minimum order quantity

100 mg

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