HDAC-IN-40
Based on 1 Customer Validation
HDAC-IN-40 is a potent alkoxyamide-based HDAC inhibitor with Ki values of 60 nM and 30 nM for HDAC2 and HDAC6, respectively. HDAC-IN-40 had antitumor effects.
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- Purity: 98.71%
- CAS No.: 2463198-51-6
- 화학식: C15H22N2O6
- 분자량:326.34
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보관:
4°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
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Biological Activity
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Chemical Information
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용액&용해도
- 순도&문서
- References
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Help & FAQs
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Biological Activity
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HDAC2 60 nM (Ki) |
HDAC6 30 nM (Ki) |
HDAC4 49200 μM (Ki) |
HDAC8 5690 nM (Ki) |
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| A2780 | IC50 |
0.83 μM
Compound: 13d
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Inhibition of HDAC in human A2780 cells
Inhibition of HDAC in human A2780 cells
|
[PMID: 31787463] |
| A2780 | IC50 |
0.89 μM
Compound: 13d
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Cytotoxicity against human A2780 cells assessed as reduction in cell viability by MTT assay
Cytotoxicity against human A2780 cells assessed as reduction in cell viability by MTT assay
|
[PMID: 31787463] |
| CAL-27 | IC50 |
0.45 μM
Compound: 13d
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Inhibition of HDAC in human Cal27 cells
Inhibition of HDAC in human Cal27 cells
|
[PMID: 31787463] |
| CAL-27 | IC50 |
0.72 μM
Compound: 13d
|
Cytotoxicity against human CAL27 cells assessed as reduction in cell viability by MTT assay
Cytotoxicity against human CAL27 cells assessed as reduction in cell viability by MTT assay
|
[PMID: 31787463] |
HDAC-IN-40 (Compound 13d) shows antiproliferative activity against the cell line A2780 and Cal27 with IC50 values of 0.89 µM and 0.72 µM, respectively[1].
HDAC-IN-40 induces accumulation of acetyl α-tubulin in Cal27 and Cal27CisR[1].
HDAC-IN-40 enhances the Cisplatin-induced cytotoxicity via caspase-3/7 activation[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 2463198-51-6
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Appearance Solid
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분자량 326.34
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화학식 C15H22N2O6
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Color Off-white to pink
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SMILES
O=C(NOCCCCCC(NO)=O)C1=CC(OC)=CC(OC)=C1
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선적
Room temperature in continental US; may vary elsewhere.
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보관
4°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
용액&용해도
DMSO : 250 mg/mL (766.07 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
순도&문서
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Data Sheet (268 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 3.0643 mL | 15.3214 mL | 30.6429 mL | 76.6072 mL |
| 5 mM | 0.6129 mL | 3.0643 mL | 6.1286 mL | 15.3214 mL | |
| 10 mM | 0.3064 mL | 1.5321 mL | 3.0643 mL | 7.6607 mL | |
| 15 mM | 0.2043 mL | 1.0214 mL | 2.0429 mL | 5.1071 mL | |
| 20 mM | 0.1532 mL | 0.7661 mL | 1.5321 mL | 3.8304 mL | |
| 25 mM | 0.1226 mL | 0.6129 mL | 1.2257 mL | 3.0643 mL | |
| 30 mM | 0.1021 mL | 0.5107 mL | 1.0214 mL | 2.5536 mL | |
| 40 mM | 0.0766 mL | 0.3830 mL | 0.7661 mL | 1.9152 mL | |
| 50 mM | 0.0613 mL | 0.3064 mL | 0.6129 mL | 1.5321 mL | |
| 60 mM | 0.0511 mL | 0.2554 mL | 0.5107 mL | 1.2768 mL | |
| 80 mM | 0.0383 mL | 0.1915 mL | 0.3830 mL | 0.9576 mL | |
| 100 mM | 0.0306 mL | 0.1532 mL | 0.3064 mL | 0.7661 mL |
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