Cat. No.: HY-164033

HOE 689

(Synonyms: Ramnodigin)

HOE 689 (Ramnodigin) is an analog of Digitoxin (HY-B1357). HOE 689 exhibits cytotoxicity to lung cancer cells and induces apoptosis in cancer cell NCI-H460 with an IC₅₀ of 52 nM.

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CAS No.: 33156-28-4
화학식: C₂₉H₄₄O₆
분자량:488.66

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Data Sheet (268 KB)

HOE 689 Chemical Structure

CAS No.: 33156-28-4

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Biological Activity
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Biological Activity

제품 설명

HOE 689 (Ramnodigin) is an analog of Digitoxin (HY-B1357). HOE 689 exhibits cytotoxicity to lung cancer cells and induces apoptosis in cancer cell NCI-H460 with an IC₅₀ of 52 nM^[1].

Cellular Effect

Cell Line	Type	Value	Description	References
786-0	GI₅₀	0.00621 μM Compound: 7, mono-7	Cytotoxicity against human 786-0 cells after 48 hrs by sulforhodamine B assay Cytotoxicity against human 786-0 cells after 48 hrs by sulforhodamine B assay	[PMID: 21660118]
786-0	GI₅₀	6.21 nM Compound: 9, C5'-Me 9	Cytotoxicity against human 786-0 cells after 48 hrs by sulforhodamine B assay Cytotoxicity against human 786-0 cells after 48 hrs by sulforhodamine B assay	[PMID: 21572583]
A498	GI₅₀	0.0207 μM Compound: 7, mono-7	Cytotoxicity against human A498 cells after 48 hrs by sulforhodamine B assay Cytotoxicity against human A498 cells after 48 hrs by sulforhodamine B assay	[PMID: 21660118]
A498	GI₅₀	20.7 nM Compound: 9, C5'-Me 9	Cytotoxicity against human A498 cells after 48 hrs by sulforhodamine B assay Cytotoxicity against human A498 cells after 48 hrs by sulforhodamine B assay	[PMID: 21572583]
A549	GI₅₀	0.00156 μM Compound: 7, mono-7	Cytotoxicity against human A549 cells after 48 hrs by sulforhodamine B assay Cytotoxicity against human A549 cells after 48 hrs by sulforhodamine B assay	[PMID: 21660118]
A549	GI₅₀	1.56 nM Compound: 9, C5'-Me 9	Cytotoxicity against human A549/ATCC cells after 48 hrs by sulforhodamine B assay Cytotoxicity against human A549/ATCC cells after 48 hrs by sulforhodamine B assay	[PMID: 21572583]
ACHN	GI₅₀	0.00431 μM Compound: 7, mono-7	Cytotoxicity against human ACHN cells after 48 hrs by sulforhodamine B assay Cytotoxicity against human ACHN cells after 48 hrs by sulforhodamine B assay	[PMID: 21660118]
ACHN	GI₅₀	4.31 nM Compound: 9, C5'-Me 9	Cytotoxicity against human ACHN cells after 48 hrs by sulforhodamine B assay Cytotoxicity against human ACHN cells after 48 hrs by sulforhodamine B assay	[PMID: 21572583]
BT-549	GI₅₀	2.41 nM Compound: 9, C5'-Me 9	Cytotoxicity against human BT549 cells after 48 hrs by sulforhodamine B assay Cytotoxicity against human BT549 cells after 48 hrs by sulforhodamine B assay	[PMID: 21572583]
CAKI-1	GI₅₀	3.32 nM Compound: 9, C5'-Me 9	Cytotoxicity against human Caki1 cells after 48 hrs by sulforhodamine B assay Cytotoxicity against human Caki1 cells after 48 hrs by sulforhodamine B assay	[PMID: 21572583]
CCRF-CEM	GI₅₀	8.49 nM Compound: 9, C5'-Me 9	Cytotoxicity against human CCRF-CEM cells after 48 hrs by sulforhodamine B assay Cytotoxicity against human CCRF-CEM cells after 48 hrs by sulforhodamine B assay	[PMID: 21572583]
COLO 205	GI₅₀	0.0296 μM Compound: 7, mono-7	Cytotoxicity against human COLO205 cells after 48 hrs by sulforhodamine B assay Cytotoxicity against human COLO205 cells after 48 hrs by sulforhodamine B assay	[PMID: 21660118]
COLO 205	GI₅₀	29.6 nM Compound: 9, C5'-Me 9	Cytotoxicity against human COLO205 cells after 48 hrs by sulforhodamine B assay Cytotoxicity against human COLO205 cells after 48 hrs by sulforhodamine B assay	[PMID: 21572583]
DU-145	GI₅₀	0.00345 μM Compound: 7, mono-7	Cytotoxicity against human DU145 cells after 48 hrs by sulforhodamine B assay Cytotoxicity against human DU145 cells after 48 hrs by sulforhodamine B assay	[PMID: 21660118]
DU-145	GI₅₀	3.45 nM Compound: 9, C5'-Me 9	Cytotoxicity against human DU145 cells after 48 hrs by sulforhodamine B assay Cytotoxicity against human DU145 cells after 48 hrs by sulforhodamine B assay	[PMID: 21572583]
EKVX	GI₅₀	0.00513 μM Compound: 7, mono-7	Cytotoxicity against human EKVX cells after 48 hrs by sulforhodamine B assay Cytotoxicity against human EKVX cells after 48 hrs by sulforhodamine B assay	[PMID: 21660118]
EKVX	GI₅₀	5.13 nM Compound: 9, C5'-Me 9	Cytotoxicity against human EKVX cells after 48 hrs by sulforhodamine B assay Cytotoxicity against human EKVX cells after 48 hrs by sulforhodamine B assay	[PMID: 21572583]
HCC 2998	GI₅₀	16.5 nM Compound: 9, C5'-Me 9	Cytotoxicity against human HCC2998 cells after 48 hrs by sulforhodamine B assay Cytotoxicity against human HCC2998 cells after 48 hrs by sulforhodamine B assay	[PMID: 21572583]
HCT-15	GI₅₀	0.0205 μM Compound: 7, mono-7	Cytotoxicity against human HCT15 cells after 48 hrs by sulforhodamine B assay Cytotoxicity against human HCT15 cells after 48 hrs by sulforhodamine B assay	[PMID: 21660118]
HCT-15	GI₅₀	20.5 nM Compound: 9, C5'-Me 9	Cytotoxicity against human HCT15 cells after 48 hrs by sulforhodamine B assay Cytotoxicity against human HCT15 cells after 48 hrs by sulforhodamine B assay	[PMID: 21572583]
HFF	CC₅₀	0.7 μM Compound: 6, alpha-L-Amip-Dig	Cytotoxicity against HFF assessed as inhibition of cell viability after 3 days by MTT assay Cytotoxicity against HFF assessed as inhibition of cell viability after 3 days by MTT assay	[PMID: 24900847]
HFF	CC₅₀	4 μM Compound: 6, alpha-L-Amip-Dig	Cytotoxicity against HFF assessed as inhibition of cell viability after 3 days by trypan blue exclusion assay Cytotoxicity against HFF assessed as inhibition of cell viability after 3 days by trypan blue exclusion assay	[PMID: 24900847]
HL-60(TB)	GI₅₀	2.96 nM Compound: 9, C5'-Me 9	Cytotoxicity against human HL-60(TB) cells after 48 hrs by sulforhodamine B assay Cytotoxicity against human HL-60(TB) cells after 48 hrs by sulforhodamine B assay	[PMID: 21572583]
HOP-62	GI₅₀	0.00855 μM Compound: 7, mono-7	Cytotoxicity against human HOP62 cells after 48 hrs by sulforhodamine B assay Cytotoxicity against human HOP62 cells after 48 hrs by sulforhodamine B assay	[PMID: 21660118]
HOP-62	GI₅₀	8.55 nM Compound: 9, C5'-Me 9	Cytotoxicity against human HOP62 cells after 48 hrs by sulforhodamine B assay Cytotoxicity against human HOP62 cells after 48 hrs by sulforhodamine B assay	[PMID: 21572583]
HOP-92	GI₅₀	0.0113 μM Compound: 7, mono-7	Cytotoxicity against human HOP92 cells after 48 hrs by sulforhodamine B assay Cytotoxicity against human HOP92 cells after 48 hrs by sulforhodamine B assay	[PMID: 21660118]
HOP-92	GI₅₀	11.3 nM Compound: 9, C5'-Me 9	Cytotoxicity against human HOP92 cells after 48 hrs by sulforhodamine B assay Cytotoxicity against human HOP92 cells after 48 hrs by sulforhodamine B assay	[PMID: 21572583]
Hs-578T	GI₅₀	0.00457 μM Compound: 7, mono-7	Cytotoxicity against human Hs578T cells after 48 hrs by sulforhodamine B assay Cytotoxicity against human Hs578T cells after 48 hrs by sulforhodamine B assay	[PMID: 21660118]
Hs-578T	GI₅₀	4.57 nM Compound: 9, C5'-Me 9	Cytotoxicity against human Hs578T cells after 48 hrs by sulforhodamine B assay Cytotoxicity against human Hs578T cells after 48 hrs by sulforhodamine B assay	[PMID: 21572583]
HT-29	GI₅₀	0.0119 μM Compound: 7, mono-7	Cytotoxicity against human HT-29 cells after 48 hrs by sulforhodamine B assay Cytotoxicity against human HT-29 cells after 48 hrs by sulforhodamine B assay	[PMID: 21660118]
HT-29	GI₅₀	11.9 nM Compound: 9, C5'-Me 9	Cytotoxicity against human HT-29 cells after 48 hrs by sulforhodamine B assay Cytotoxicity against human HT-29 cells after 48 hrs by sulforhodamine B assay	[PMID: 21572583]
IGROV-1	GI₅₀	5.23 nM Compound: 9, C5'-Me 9	Cytotoxicity against human IGROV1 cells after 48 hrs by sulforhodamine B assay Cytotoxicity against human IGROV1 cells after 48 hrs by sulforhodamine B assay	[PMID: 21572583]
K562	GI₅₀	19.5 nM Compound: 9, C5'-Me 9	Cytotoxicity against human K562 cells after 48 hrs by sulforhodamine B assay Cytotoxicity against human K562 cells after 48 hrs by sulforhodamine B assay	[PMID: 21572583]
KM12	GI₅₀	0.0324 μM Compound: 7, mono-7	Cytotoxicity against human KM12 cells after 48 hrs by sulforhodamine B assay Cytotoxicity against human KM12 cells after 48 hrs by sulforhodamine B assay	[PMID: 21660118]
KM12	GI₅₀	32.4 nM Compound: 9, C5'-Me 9	Cytotoxicity against human KM12 cells after 48 hrs by sulforhodamine B assay Cytotoxicity against human KM12 cells after 48 hrs by sulforhodamine B assay	[PMID: 21572583]
LOX IMVI	GI₅₀	0.0118 μM Compound: 7, mono-7	Cytotoxicity against human LOXIMVI cells after 48 hrs by sulforhodamine B assay Cytotoxicity against human LOXIMVI cells after 48 hrs by sulforhodamine B assay	[PMID: 21660118]
LOX IMVI	GI₅₀	11.8 nM Compound: 9, C5'-Me 9	Cytotoxicity against human LOXIMVI cells after 48 hrs by sulforhodamine B assay Cytotoxicity against human LOXIMVI cells after 48 hrs by sulforhodamine B assay	[PMID: 21572583]
M14	GI₅₀	0.0193 μM Compound: 7, mono-7	Cytotoxicity against human M14 cells after 48 hrs by sulforhodamine B assay Cytotoxicity against human M14 cells after 48 hrs by sulforhodamine B assay	[PMID: 21660118]
M14	GI₅₀	19.3 nM Compound: 9, C5'-Me 9	Cytotoxicity against human M14 cells after 48 hrs by sulforhodamine B assay Cytotoxicity against human M14 cells after 48 hrs by sulforhodamine B assay	[PMID: 21572583]
Malme-3M	GI₅₀	0.0183 μM Compound: 7, mono-7	Cytotoxicity against human MALME-3M cells after 48 hrs by sulforhodamine B assay Cytotoxicity against human MALME-3M cells after 48 hrs by sulforhodamine B assay	[PMID: 21660118]
Malme-3M	GI₅₀	18.3 nM Compound: 9, C5'-Me 9	Cytotoxicity against human MALME-3M cells after 48 hrs by sulforhodamine B assay Cytotoxicity against human MALME-3M cells after 48 hrs by sulforhodamine B assay	[PMID: 21572583]
MCF7	GI₅₀	0.00589 μM Compound: 7, mono-7	Cytotoxicity against human MCF7 cells after 48 hrs by sulforhodamine B assay Cytotoxicity against human MCF7 cells after 48 hrs by sulforhodamine B assay	[PMID: 21660118]
MCF7	GI₅₀	5.89 nM Compound: 9, C5'-Me 9	Cytotoxicity against human MCF7 cells after 48 hrs by sulforhodamine B assay Cytotoxicity against human MCF7 cells after 48 hrs by sulforhodamine B assay	[PMID: 21572583]
MDA-MB-231	GI₅₀	0.0339 μM Compound: 7, mono-7	Cytotoxicity against human MDA-MB-231 cells after 48 hrs by sulforhodamine B assay Cytotoxicity against human MDA-MB-231 cells after 48 hrs by sulforhodamine B assay	[PMID: 21660118]
MDA-MB-231	GI₅₀	33.9 nM Compound: 9, C5'-Me 9	Cytotoxicity against human MDA-MB-231 cells after 48 hrs by sulforhodamine B assay Cytotoxicity against human MDA-MB-231 cells after 48 hrs by sulforhodamine B assay	[PMID: 21572583]
MDA-MB-435	GI₅₀	0.0277 μM Compound: 7, mono-7	Cytotoxicity against human MDA-MB-435 cells after 48 hrs by sulforhodamine B assay Cytotoxicity against human MDA-MB-435 cells after 48 hrs by sulforhodamine B assay	[PMID: 21660118]
MDA-MB-435	GI₅₀	21 nM Compound: 9, C5'-Me 9	Cytotoxicity against human MDA-MB-435 breast cancer cells after 48 hrs by sulforhodamine B assay Cytotoxicity against human MDA-MB-435 breast cancer cells after 48 hrs by sulforhodamine B assay	[PMID: 21572583]
MDA-MB-435	GI₅₀	27.7 nM Compound: 9, C5'-Me 9	Cytotoxicity against human MDA-MB-435 melanoma cells after 48 hrs by sulforhodamine B assay Cytotoxicity against human MDA-MB-435 melanoma cells after 48 hrs by sulforhodamine B assay	[PMID: 21572583]
MOLT-4	GI₅₀	0.00257 μM Compound: 7, mono-7	Cytotoxicity against human MOLT4 cells after 48 hrs by sulforhodamine B assay Cytotoxicity against human MOLT4 cells after 48 hrs by sulforhodamine B assay	[PMID: 21660118]
MOLT-4	GI₅₀	2.57 nM Compound: 9, C5'-Me 9	Cytotoxicity against human MOLT4 cells after 48 hrs by sulforhodamine B assay Cytotoxicity against human MOLT4 cells after 48 hrs by sulforhodamine B assay	[PMID: 21572583]
NCI/ADR-RES	GI₅₀	4.12 nM Compound: 9, C5'-Me 9	Cytotoxicity against human NCI/ADR-RES cells after 48 hrs by sulforhodamine B assay Cytotoxicity against human NCI/ADR-RES cells after 48 hrs by sulforhodamine B assay	[PMID: 21572583]
NCI-H226	GI₅₀	0.0193 μM Compound: 7, mono-7	Cytotoxicity against human NCI-H226 cells after 48 hrs by sulforhodamine B assay Cytotoxicity against human NCI-H226 cells after 48 hrs by sulforhodamine B assay	[PMID: 21660118]
NCI-H226	GI₅₀	19.3 nM Compound: 9, C5'-Me 9	Cytotoxicity against human NCI-H226 cells after 48 hrs by sulforhodamine B assay Cytotoxicity against human NCI-H226 cells after 48 hrs by sulforhodamine B assay	[PMID: 21572583]
NCI-H23	GI₅₀	0.00413 μM Compound: 7, mono-7	Cytotoxicity against human NCI-H23 cells after 48 hrs by sulforhodamine B assay Cytotoxicity against human NCI-H23 cells after 48 hrs by sulforhodamine B assay	[PMID: 21660118]
NCI-H23	GI₅₀	4.13 nM Compound: 9, C5'-Me 9	Cytotoxicity against human NCI-H23 cells after 48 hrs by sulforhodamine B assay Cytotoxicity against human NCI-H23 cells after 48 hrs by sulforhodamine B assay	[PMID: 21572583]
NCI-H322M	GI₅₀	0.00778 μM Compound: 7, mono-7	Cytotoxicity against human NCI-H322M cells after 48 hrs by sulforhodamine B assay Cytotoxicity against human NCI-H322M cells after 48 hrs by sulforhodamine B assay	[PMID: 21660118]
NCI-H322M	GI₅₀	7.78 nM Compound: 9, C5'-Me 9	Cytotoxicity against human NCI-H322M cells after 48 hrs by sulforhodamine B assay Cytotoxicity against human NCI-H322M cells after 48 hrs by sulforhodamine B assay	[PMID: 21572583]
NCI-H460	GI₅₀	0.00383 μM Compound: 7, mono-7	Cytotoxicity against human NCI-H460 cells after 48 hrs by sulforhodamine B assay Cytotoxicity against human NCI-H460 cells after 48 hrs by sulforhodamine B assay	[PMID: 21660118]
NCI-H460	GI₅₀	1.927 nM Compound: 9, C5'-Me 9	Cytotoxicity against human NCI-H460 cells assessed as cell viability after 48 hrs by MTT assay Cytotoxicity against human NCI-H460 cells assessed as cell viability after 48 hrs by MTT assay	[PMID: 21572583]
NCI-H460	GI₅₀	2 nM Compound: 9, C5'-Me 9	Growth inhibition of human NCI-H460 cells after 48 hrs by MTT assay Growth inhibition of human NCI-H460 cells after 48 hrs by MTT assay	[PMID: 21572583]
NCI-H460	GI₅₀	2.2 nM Compound: 7,alpha-L-amicetose	Growth inhibition of human NCI-H460 cells after 48 hrs by MTT assay Growth inhibition of human NCI-H460 cells after 48 hrs by MTT assay	[PMID: 21643465]
NCI-H460	GI₅₀	3.83 nM Compound: 9, C5'-Me 9	Cytotoxicity against human NCI-H460 cells after 48 hrs by sulforhodamine B assay Cytotoxicity against human NCI-H460 cells after 48 hrs by sulforhodamine B assay	[PMID: 21572583]
NCI-H460	IC₅₀	47.98 nM Compound: 7, mono-7	Cytotoxicity against human NCI-H460 cell assessed as cell death after 12 hrs by Hoechst 33342/propidium iodide staining based fluorescence microscopy Cytotoxicity against human NCI-H460 cell assessed as cell death after 12 hrs by Hoechst 33342/propidium iodide staining based fluorescence microscopy	[PMID: 21660118]
NCI-H460	IC₅₀	51.73 nM Compound: 9, C5'-Me 9	Induction of apoptosis in human NCI-H460 cells in serum free medium after 12 hrs by Hoechst 33342/propidium iodide staining based fluorescence microscopy Induction of apoptosis in human NCI-H460 cells in serum free medium after 12 hrs by Hoechst 33342/propidium iodide staining based fluorescence microscopy	[PMID: 21572583]
NCI-H460	IC₅₀	52 nM Compound: 9, C5'-Me 9	Cytotoxicity in human NCI-H460 cells in serum free medium at 50 nM after 12 hrs by Hoechst 33342/propidium iodide staining based fluorescence microscopy Cytotoxicity in human NCI-H460 cells in serum free medium at 50 nM after 12 hrs by Hoechst 33342/propidium iodide staining based fluorescence microscopy	[PMID: 21572583]
NCI-H460	IC₅₀	55.7 nM Compound: 7,alpha-L-amicetose	Cytotoxicity against human NCI-H460 cells assessed as cell death at 50 nM after 12 hrs by Hoechst-33342 staining and propidium iodide staining Cytotoxicity against human NCI-H460 cells assessed as cell death at 50 nM after 12 hrs by Hoechst-33342 staining and propidium iodide staining	[PMID: 21643465]
NCI-H522	GI₅₀	0.00938 μM Compound: 7, mono-7	Cytotoxicity against human NCI-H522 cells after 48 hrs by sulforhodamine B assay Cytotoxicity against human NCI-H522 cells after 48 hrs by sulforhodamine B assay	[PMID: 21660118]
NCI-H522	GI₅₀	9.38 nM Compound: 9, C5'-Me 9	Cytotoxicity against human NCI-H522 cells after 48 hrs by sulforhodamine B assay Cytotoxicity against human NCI-H522 cells after 48 hrs by sulforhodamine B assay	[PMID: 21572583]
OVCAR-3	GI₅₀	0.00494 μM Compound: 7, mono-7	Cytotoxicity against human OVCAR3 cells after 48 hrs by sulforhodamine B assay Cytotoxicity against human OVCAR3 cells after 48 hrs by sulforhodamine B assay	[PMID: 21660118]
OVCAR-3	GI₅₀	4.94 nM Compound: 9, C5'-Me 9	Cytotoxicity against human OVCAR3 cells after 48 hrs by sulforhodamine B assay Cytotoxicity against human OVCAR3 cells after 48 hrs by sulforhodamine B assay	[PMID: 21572583]
OVCAR-4	GI₅₀	0.0189 μM Compound: 7, mono-7	Cytotoxicity against human OVCAR4 cells after 48 hrs by sulforhodamine B assay Cytotoxicity against human OVCAR4 cells after 48 hrs by sulforhodamine B assay	[PMID: 21660118]
OVCAR-4	GI₅₀	18.9 nM Compound: 9, C5'-Me 9	Cytotoxicity against human OVCAR4 cells after 48 hrs by sulforhodamine B assay Cytotoxicity against human OVCAR4 cells after 48 hrs by sulforhodamine B assay	[PMID: 21572583]
OVCAR-5	GI₅₀	17.4 nM Compound: 9, C5'-Me 9	Cytotoxicity against human OVCAR5 cells after 48 hrs by sulforhodamine B assay Cytotoxicity against human OVCAR5 cells after 48 hrs by sulforhodamine B assay	[PMID: 21572583]
OVCAR-8	GI₅₀	0.0025 μM Compound: 7, mono-7	Cytotoxicity against human OVCAR8 cells after 48 hrs by sulforhodamine B assay Cytotoxicity against human OVCAR8 cells after 48 hrs by sulforhodamine B assay	[PMID: 21660118]
OVCAR-8	GI₅₀	2.5 nM Compound: 9, C5'-Me 9	Cytotoxicity against human OVCAR8 cells after 48 hrs by sulforhodamine B assay Cytotoxicity against human OVCAR8 cells after 48 hrs by sulforhodamine B assay	[PMID: 21572583]
PC-3	GI₅₀	0.00955 μM Compound: 7, mono-7	Cytotoxicity against human PC3 cells after 48 hrs by sulforhodamine B assay Cytotoxicity against human PC3 cells after 48 hrs by sulforhodamine B assay	[PMID: 21660118]
PC-3	GI₅₀	9.55 nM Compound: 9, C5'-Me 9	Cytotoxicity against human PC3 cells after 48 hrs by sulforhodamine B assay Cytotoxicity against human PC3 cells after 48 hrs by sulforhodamine B assay	[PMID: 21572583]
RPMI-8226	GI₅₀	0.0235 μM Compound: 7, mono-7	Cytotoxicity against human RPMI8226 cells after 48 hrs by sulforhodamine B assay Cytotoxicity against human RPMI8226 cells after 48 hrs by sulforhodamine B assay	[PMID: 21660118]
RPMI-8226	GI₅₀	23.5 nM Compound: 9, C5'-Me 9	Cytotoxicity against human RPMI8226 cells after 48 hrs by sulforhodamine B assay Cytotoxicity against human RPMI8226 cells after 48 hrs by sulforhodamine B assay	[PMID: 21572583]
RXF 393	GI₅₀	1.22 nM Compound: 9, C5'-Me 9	Cytotoxicity against human RXF393 cells after 48 hrs by sulforhodamine B assay Cytotoxicity against human RXF393 cells after 48 hrs by sulforhodamine B assay	[PMID: 21572583]
SF-268	GI₅₀	0.00428 μM Compound: 7, mono-7	Cytotoxicity against human SF268 cells after 48 hrs by sulforhodamine B assay Cytotoxicity against human SF268 cells after 48 hrs by sulforhodamine B assay	[PMID: 21660118]
SF-268	GI₅₀	4.28 nM Compound: 9, C5'-Me 9	Cytotoxicity against human SF268 cells after 48 hrs by sulforhodamine B assay Cytotoxicity against human SF268 cells after 48 hrs by sulforhodamine B assay	[PMID: 21572583]
SF-295	GI₅₀	0.0104 μM Compound: 7, mono-7	Cytotoxicity against human SF295 cells after 48 hrs by sulforhodamine B assay Cytotoxicity against human SF295 cells after 48 hrs by sulforhodamine B assay	[PMID: 21660118]
SF-295	GI₅₀	10.4 nM Compound: 9, C5'-Me 9	Cytotoxicity against human SF295 cells after 48 hrs by sulforhodamine B assay Cytotoxicity against human SF295 cells after 48 hrs by sulforhodamine B assay	[PMID: 21572583]
SF-539	GI₅₀	0.0078 μM Compound: 7, mono-7	Cytotoxicity against human SF539 cells after 48 hrs by sulforhodamine B assay Cytotoxicity against human SF539 cells after 48 hrs by sulforhodamine B assay	[PMID: 21660118]
SF-539	GI₅₀	7.8 nM Compound: 9, C5'-Me 9	Cytotoxicity against human SF539 cells after 48 hrs by sulforhodamine B assay Cytotoxicity against human SF539 cells after 48 hrs by sulforhodamine B assay	[PMID: 21572583]
SK-MEL-28	GI₅₀	0.0231 μM Compound: 7, mono-7	Cytotoxicity against human SK-MEL-28 cells after 48 hrs by sulforhodamine B assay Cytotoxicity against human SK-MEL-28 cells after 48 hrs by sulforhodamine B assay	[PMID: 21660118]
SK-MEL-28	GI₅₀	23.1 nM Compound: 9, C5'-Me 9	Cytotoxicity against human SK-MEL-28 cells after 48 hrs by sulforhodamine B assay Cytotoxicity against human SK-MEL-28 cells after 48 hrs by sulforhodamine B assay	[PMID: 21572583]
SK-MEL-5	GI₅₀	0.00544 μM Compound: 7, mono-7	Cytotoxicity against human SK-MEL-5 cells after 48 hrs by sulforhodamine B assay Cytotoxicity against human SK-MEL-5 cells after 48 hrs by sulforhodamine B assay	[PMID: 21660118]
SK-MEL-5	GI₅₀	5.44 nM Compound: 9, C5'-Me 9	Cytotoxicity against human SK-MEL-5 cells after 48 hrs by sulforhodamine B assay Cytotoxicity against human SK-MEL-5 cells after 48 hrs by sulforhodamine B assay	[PMID: 21572583]
SK-OV-3	GI₅₀	0.0222 μM Compound: 7, mono-7	Cytotoxicity against human SKOV3 cells after 48 hrs by sulforhodamine B assay Cytotoxicity against human SKOV3 cells after 48 hrs by sulforhodamine B assay	[PMID: 21660118]
SK-OV-3	GI₅₀	22.2 nM Compound: 9, C5'-Me 9	Cytotoxicity against human SKOV3 cells after 48 hrs by sulforhodamine B assay Cytotoxicity against human SKOV3 cells after 48 hrs by sulforhodamine B assay	[PMID: 21572583]
SN12C	GI₅₀	0.00361 μM Compound: 7, mono-7	Cytotoxicity against human SN12C cells after 48 hrs by sulforhodamine B assay Cytotoxicity against human SN12C cells after 48 hrs by sulforhodamine B assay	[PMID: 21660118]
SN12C	GI₅₀	3.61 nM Compound: 9, C5'-Me 9	Cytotoxicity against human SN12C cells after 48 hrs by sulforhodamine B assay Cytotoxicity against human SN12C cells after 48 hrs by sulforhodamine B assay	[PMID: 21572583]
SNB-19	GI₅₀	0.0375 μM Compound: 7, mono-7	Cytotoxicity against human SNB19 cells after 48 hrs by sulforhodamine B assay Cytotoxicity against human SNB19 cells after 48 hrs by sulforhodamine B assay	[PMID: 21660118]
SNB-19	GI₅₀	37.5 nM Compound: 9, C5'-Me 9	Cytotoxicity against human SNB19 cells after 48 hrs by sulforhodamine B assay Cytotoxicity against human SNB19 cells after 48 hrs by sulforhodamine B assay	[PMID: 21572583]
SNB-75	GI₅₀	0.0149 μM Compound: 7, mono-7	Cytotoxicity against human SNB75 cells after 48 hrs by sulforhodamine B assay Cytotoxicity against human SNB75 cells after 48 hrs by sulforhodamine B assay	[PMID: 21660118]
SNB-75	GI₅₀	14.9 nM Compound: 9, C5'-Me 9	Cytotoxicity against human SNB75 cells after 48 hrs by sulforhodamine B assay Cytotoxicity against human SNB75 cells after 48 hrs by sulforhodamine B assay	[PMID: 21572583]
SR	GI₅₀	0.00225 μM Compound: 7, mono-7	Cytotoxicity against human SR cells after 48 hrs by sulforhodamine B assay Cytotoxicity against human SR cells after 48 hrs by sulforhodamine B assay	[PMID: 21660118]
SR	GI₅₀	2.25 nM Compound: 9, C5'-Me 9	Cytotoxicity against human SR cells after 48 hrs by sulforhodamine B assay Cytotoxicity against human SR cells after 48 hrs by sulforhodamine B assay	[PMID: 21572583]
SW-620	GI₅₀	0.0111 μM Compound: 7, mono-7	Cytotoxicity against human SW620 cells after 48 hrs by sulforhodamine B assay Cytotoxicity against human SW620 cells after 48 hrs by sulforhodamine B assay	[PMID: 21660118]
SW-620	GI₅₀	11.1 nM Compound: 9, C5'-Me 9	Cytotoxicity against human SW620 cells after 48 hrs by sulforhodamine B assay Cytotoxicity against human SW620 cells after 48 hrs by sulforhodamine B assay	[PMID: 21572583]
T47D	GI₅₀	0.021 μM Compound: 7, mono-7	Cytotoxicity against human T47D cells after 48 hrs by sulforhodamine B assay Cytotoxicity against human T47D cells after 48 hrs by sulforhodamine B assay	[PMID: 21660118]
T47D	GI₅₀	20.6 nM Compound: 9, C5'-Me 9	Cytotoxicity against human T47D cells after 48 hrs by sulforhodamine B assay Cytotoxicity against human T47D cells after 48 hrs by sulforhodamine B assay	[PMID: 21572583]
TK-10	GI₅₀	0.00375 μM Compound: 7, mono-7	Cytotoxicity against human TK10 cells after 48 hrs by sulforhodamine B assay Cytotoxicity against human TK10 cells after 48 hrs by sulforhodamine B assay	[PMID: 21660118]
TK-10	GI₅₀	3.75 nM Compound: 9, C5'-Me 9	Cytotoxicity against human TK10 cells after 48 hrs by sulforhodamine B assay Cytotoxicity against human TK10 cells after 48 hrs by sulforhodamine B assay	[PMID: 21572583]
U-251	GI₅₀	0.00257 μM Compound: 7, mono-7	Cytotoxicity against human U251 cells after 48 hrs by sulforhodamine B assay Cytotoxicity against human U251 cells after 48 hrs by sulforhodamine B assay	[PMID: 21660118]
U-251	GI₅₀	12.7 nM Compound: 9, C5'-Me 9	Cytotoxicity against human U251 cells after 48 hrs by sulforhodamine B assay Cytotoxicity against human U251 cells after 48 hrs by sulforhodamine B assay	[PMID: 21572583]
UACC-257	GI₅₀	0.0196 μM Compound: 7, mono-7	Cytotoxicity against human UACC257 cells after 48 hrs by sulforhodamine B assay Cytotoxicity against human UACC257 cells after 48 hrs by sulforhodamine B assay	[PMID: 21660118]
UACC-257	GI₅₀	19.6 nM Compound: 9, C5'-Me 9	Cytotoxicity against human UACC257 cells after 48 hrs by sulforhodamine B assay Cytotoxicity against human UACC257 cells after 48 hrs by sulforhodamine B assay	[PMID: 21572583]
UACC-62	GI₅₀	0.0127 μM Compound: 7, mono-7	Cytotoxicity against human UACC62 cells after 48 hrs by sulforhodamine B assay Cytotoxicity against human UACC62 cells after 48 hrs by sulforhodamine B assay	[PMID: 21660118]
UACC-62	GI₅₀	12.7 nM Compound: 9, C5'-Me 9	Cytotoxicity against human UACC62 cells after 48 hrs by sulforhodamine B assay Cytotoxicity against human UACC62 cells after 48 hrs by sulforhodamine B assay	[PMID: 21572583]
UO-31	GI₅₀	0.00515 μM Compound: 7, mono-7	Cytotoxicity against human UO31 cells after 48 hrs by sulforhodamine B assay Cytotoxicity against human UO31 cells after 48 hrs by sulforhodamine B assay	[PMID: 21660118]
UO-31	GI₅₀	5.15 nM Compound: 9, C5'-Me 9	Cytotoxicity against human UO31 cells after 48 hrs by sulforhodamine B assay Cytotoxicity against human UO31 cells after 48 hrs by sulforhodamine B assay	[PMID: 21572583]

Chemical Information

CAS No. 33156-28-4
분자량 488.66
화학식 C₂₉H₄₄O₆
SMILES

O[C@@]12[C@@]3([H])[C@@](CC[C@@]1([C@@H](C(CO4)=CC4=O)CC2)C)([H])[C@@]5([C@](C[C@H](CC5)O[C@@H]6O[C@H]([C@@H](CC6)O)C)([H])CC3)C
Synonyms

Ramnodigin
선적

Room temperature in continental US; may vary elsewhere.
보관

Please store the product under the recommended conditions in the Certificate of Analysis.

순도&문서

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (268 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Wang HY, et al., C5'-Alkyl Substitution Effects on Digitoxigenin α-l-Glycoside Cancer Cytotoxicity. ACS Med Chem Lett. 2011 Apr 14;2(4):259-263. [Content Brief]

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

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