Human CES2 Enzyme
Based on 1 Customer Validation
Human CES2 Enzyme is a carboxylesterase involved in drug metabolism and lipid homeostasis. Human CES2 Enzyme hydrolyzes triglycerides, cholesteryl esters and retinyl esters to regulate lipid metabolism and energy homeostasis. Human CES2 Enzyme improves glucose tolerance and insulin sensitivity, reduces hepatic lipid accumulation, alleviates white adipose tissue steatitis, decreases plasma cholesterol levels, and reduces body weight and white adipose tissue weight. Human CES2 Enzyme can be used in the research of metabolic syndrome.
연구목적의 판매만을 진행합니다. 환자를 대상으로 한 판매는 하지 않습니다.
- Purity: 95.00%
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보관:
Please store the product under the recommended conditions in the Certificate of Analysis.
Biological Activity
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:FVB/NRj mice (4-60 weeks old) with global Ces2 cluster knockout and liver- or intestine-specific human CES2 transgenic modification on Ces2-/- background[1]
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Dosage:/
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Administration:/
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Result:Significantly reduced the elevated plasma AUC and tissue concentration of capecitabine in global Ces2 cluster knockout mice.
Alleviated fatty liver, adipositis, hypercholesterolemia, impaired glucose tolerance and insulin sensitivity caused by Ces2 deficiency, but increased liver size, adipose tissue mass and total body weight (Hepatic).
Effectively rescued all metabolic syndrome phenotypes and even improved some indicators such as body weight compared with wild-type mice (Intestinal).
Chemical Information
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SMILES
[Human CES2 Enzyme]
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선적
Room temperature in continental US; may vary elsewhere.
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보관
Please store the product under the recommended conditions in the Certificate of Analysis.
순도&문서
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)