Copy Link Print Information

ISRIB

35 Cited Publications
고객리뷰

Based on 35 publication(s) in Google Scholar

ISRIB is a brain-penetrant inhibitor of integrated stress response (ISR). Persistent activation of the ISR has been linked to the development of several neurological disorders as ISR represses translation through inhibiting eIF2B. ISRIB inhibits the ISR by promoting the nucleotide exchange activity of eIF2B and recovering the translation, and thus can be used for neurological disorders research.

연구목적의 판매만을 진행합니다. 환자를 대상으로 한 판매는 하지 않습니다.

  • Purity: 99.0%
  • CAS No.: 548470-11-7
  • 화학식: C22H24Cl2N2O4
  • 분자량:451.34
  • 보관:
    Powder   -20°C, 3 years , 4°C, 2 years ; In solvent   -80°C, 6 months , -20°C, 1 month
  • ISRIB Chemical Structure
    ISRIB Chemical Structure
  • Experimental Validation Results for ISRIB
  • Experimental Validation Results for ISRIB
  • Experimental Validation Results for ISRIB
  • Experimental Validation Results for ISRIB
  • Experimental Validation Results for ISRIB
CAS No.: 548470-11-7
사이즈
가격
재고
수량
Amount: USD 0.00
Please select quantity
or
or

* 장바구니에 담기 전 물품의 수량을 선택해 주십시오.

To place orders, for customer services and technical support, please contact: MedChemExpress USA

Tel: 609-228-6898 E-mail: [email protected] [email protected]

Data Download
Other Forms of ISRIB:

To place orders, for customer services and technical support, please contact:

609-228-6898
[email protected] [email protected]
주변의 대리점 찾기 Your local distributor: Hycultec GmbHHycultec
  • Biological Activity
  • Chemical Information
  • 용액&용해도
  • 순도&문서
  • References
  • Help & FAQs
Top Publications Citing

Use of MCE Products

Publications Citing Use of MedChemExpress (MCE) ISRIB

More
Customer Validation & Images
WBHistological Imaging/StainingCell Proliferation/Viability AssayRT-PCR
  • Histological Imaging/Staining
  • RT-PCR
  • WB
  • Cell Proliferation/Viability Assay
  • WB
Keywords
100 mg

견적 받기 해외재고보유

Please select quantity
Amount: USD 0.00
Sign in to MedChemExpress 로그인
Register
Sign in to MedChemExpress
회원가입

At least 6 characters

Personalize your experience, you are currently not signed in. For a better experience, please create an online profile, you can:

Obtain points redemption prizes
Check out faster
Add multiple shipping locations
View orders
Assay Types
  • ISRIB Chemical Structure
    ISRIB Chemical Structure
    1/16
  • 1/16

    ISRIB purchased from MedChemExpress. Usage Cited in: Redox Biol. 2025 Dec:88:103905. [Abstract]

    Customer Validation
     Schematic illustrating ISRIB treatment regimen (20 mg/kg, administered twice weekly from weeks 4–8) in CCl4-induced fibrotic mouse models. (B) Representative images of HE staining in liver sections after CCl4 treatment.

  • 1/16

    ISRIB purchased from MedChemExpress. Usage Cited in: Redox Biol. 2025 Dec:88:103905. [Abstract]

    Customer Validation
     Schematic illustrating ISRIB treatment regimen (20 mg/kg, administered twice weekly from weeks 4–8) in CCl4-induced fibrotic mouse models. Relative gene expression levels of ATF4 in liver tissues after CCl4 injection for 8 weeks (n = 4).

  • 1/16

    ISRIB purchased from MedChemExpress. Usage Cited in: Int J Oral Sci. 2024 May 8;16(1):35. [Abstract]

    Customer Validation
     Protein expression levels of ATF4, DDIT4, NIBAN1, p62, ATG5, and LC3-I/II were analyzed by Western blot in CAL 27 cells at 4 h after treatment with 1 mmol/L phenformin (Phen), 200 nmol/L ISRIB, or DMSO as a control.

  • 1/16

    ISRIB purchased from MedChemExpress. Usage Cited in: Int J Oral Sci. 2024 May 8;16(1):35. [Abstract]

    Customer Validation
     CAL 27 cells were treated with 1 mmol/L phenformin (Phen) or with 200 nmol/L ISRIB or 1 μmol/L GSK2606414 or DMSO as a control. At 24 h, cells were collected and analyzed by the CCK-8 assay for cell viability.

  • 1/16

    ISRIB purchased from MedChemExpress. Usage Cited in: J Virol. 2018 Jul 31;92(16). pii: e00600-18. [Abstract]

    Customer Validation
     MARC-145 cells grown in six-well plates are treated with 0.5 mM Ars at 37°C for 1 h. The medium is changed to medium containing different concentrations of ISRIB and after 25 min, the cells are treated with puromycin, incubated at 37°C for 25 min, and lysed for western blotting analysis.

  • ISRIB