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Cat. No.: HY-163280

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JGB-1-155

JGB-1-155 is a nicotinamide phosphoribosyltransferase (NAMPT) activator and also a reactive oxygen species (ROS) inhibitor. JGB-1-155 binds to NAMPT, thereby enhancing its catalytic activity and increasing intracellular NAD⁺ levels. JGB-1-155 alleviates the elevation of ROS levels induced by various types of damage. JGB-1-155 can be used in research related to neurodegenerative diseases.

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CAS No.: 3011930-28-9
화학식: C₂₆H₃₈N₂O₃
분자량:426.59

보관:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (273 KB)

JGB-1-155 Chemical Structure

CAS No.: 3011930-28-9

Amount: USD 0.00

* 장바구니에 담기 전 물품의 수량을 선택해 주십시오.

Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- 제품 설명
- IC₅₀ & Target
- In Vitro
Chemical Information
순도&문서
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

제품 설명

IC₅₀ & Target

EC₅₀: NAMPT (3.29 μM)

In Vitro

JGB-1-155 exerts positive allosteric regulation on purified NAMPT, with an EC₅₀ of 3.29 μM and a maximum activation fold of 1.41^[1].
JGB-1-155 (3-40 μM) increases NAD⁺ levels in human THP-1 monocytes in a concentration-dependent manner by directly activating NAMPT^[1].
JGB-1-155 activates purified NAMPT enzyme with an EC₅₀ of 3.88 μM^[2].
JGB-1-155 (20-40 μM) attenuates TNFα-induced mitochondrial ROS production in mouse HT-22 hippocampal neuron cells in a concentration-dependent manner^[1].
JGB-1-155 (1.25-40 μM) attenuates glutamate-induced mitochondrial ROS in mouse HT-22 hippocampal neuron cells in a concentration-dependent manner^[1].
JGB-1-155 (1.25-20 μM; overnight pre-incubation; overnight insult incubation) reduces ROS levels in HT-22 cells exposed to VK₃, glutamate, TNFα or hyperconfluent conditions in a dose-dependent manner^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 3011930-28-9
분자량 426.59
화학식 C₂₆H₃₈N₂O₃
SMILES

O=C(N(CCC1(C(C)C)CCOC(C)(C1)C)CC2=CC=C(N(C)C)C=C2)C3=CC=CO3
선적

Room temperature in continental US; may vary elsewhere.
보관

Please store the product under the recommended conditions in the Certificate of Analysis.

순도&문서

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (273 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Gordon-Blake J, et al. Nicotinamide Phosphoribosyltransferase Positive Allosteric Modulators Attenuate Neuronal Oxidative Stress. ACS medicinal chemistry letters. 2024 Feb 08;15(2):205-214. [Content Brief]

[2]. Gordon-Blake J. Development of NAMPT Positive Allosteric Modulators as Potential Alzheimer’s Disease Therapeutics. Chicago: University of Illinois Chicago, 2022.

Calculators

몰농도 계산기

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

농도 희석 계산기

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

Keywords

MOQ

Minimum order quantity

100 mg

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