Junceellolide C
Junceellolide C is a transcription inhibitor of cccDNA. Junceellolide C inhibits HBV DNA replication and significantly decreases the level of supernatant HBV RNA with EC50 values of 5.19, 3.52 μM respectively in HepAD38 cells. Junceellolide C is a potent anti-HBV agent.
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- CAS No.: 121769-82-2
- 화학식: C26H33ClO10
- 분자량:540.99
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보관:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- 순도&문서
- References
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Help & FAQs
Biological Activity
EC50: 2.27 μM (HBV DNA replication), 3.52 μM (HBV RNA decrease) in HBeAg cells[1]
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| BMDM | CC50 |
>50 μM
Compound: 31
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Cytotoxicity against C57BL/6 mouse BMDM cells incubated for 48 hrs by MTT assay
Cytotoxicity against C57BL/6 mouse BMDM cells incubated for 48 hrs by MTT assay
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[PMID: 36446206] |
| HepG2 | CC50 |
>100 μM
Compound: 27
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Cytotoxicity against human HepG2 cells assessed as cell viability incubated for 72 hrs by MTT assay
Cytotoxicity against human HepG2 cells assessed as cell viability incubated for 72 hrs by MTT assay
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[PMID: 32690259] |
Junceellolide C (10 μM; 72 hours) inhibits HBV DNA replication and significantly decreases the level of supernatant HBV RNA in HepAD38 cells with EC50 values of 2.27, 3.52 μM, respectively[1].
Junceellolide C (10 μM; 8 days) can capable to inhibit HBV cccDNA replenishment and also to induce the existed HBV cccDNA degradation[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:HepAD38 cells
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Concentration:10 μM
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Incubation Time:72 h, 8 days
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Result:Inhibited cccDNA transcription.
Chemical Information
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CAS No. 121769-82-2
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분자량 540.99
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화학식 C26H33ClO10
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SMILES
C[C@@]12[C@]([C@@H]([C@]3([C@@]([C@H](C(/C=C\[C@@H]2OC(C)=O)=C)Cl)([H])OC([C@@H]3C)=O)O)OC(C)=O)([H])[C@]4(CC[C@@H]1OC(C)=O)CO4
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Structure Classification
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Initial Source
South China Sea gorgonian Dichotella gemmacea
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선적
Room temperature in continental US; may vary elsewhere.
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보관
Please store the product under the recommended conditions in the Certificate of Analysis.
순도&문서
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Junceellolide C Related Classifications
HY-N10404 Related Classifications
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