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Cat. No.: HY-123141

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K00135

고객리뷰

Based on 1 Customer Validation

K00135 is a potent and selective inhibitor of PIM kinases. K00135 inhibits survival and clonogenic growth of acute leukemia cells. K00135 inhibits the phosphorylation of PIM downstream targets.

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Purity: 98.03%
CAS No.: 869650-21-5
화학식: C₁₈H₁₈N₄O
분자량:306.36

보관:

Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month

K00135 Chemical Structure

CAS No.: 869650-21-5

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Amount: USD 0.00

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- 제품 설명
- Cellular Effect
Chemical Information
용액&용해도
- In Vitro
순도&문서
References
Help & FAQs
Classifications
Bioz

Biological Activity

제품 설명

K00135 is a potent and selective inhibitor of PIM kinases. K00135 inhibits survival and clonogenic growth of acute leukemia cells. K00135 inhibits the phosphorylation of PIM downstream targets^[1].

All Pim Isoforms :

Cellular Effect

Cell Line	Type	Value	Description	References
K562	IC₅₀	8 μM Compound: K00135	Growth inhibition of human K562 cells after 48 hrs by WST-1 assay Growth inhibition of human K562 cells after 48 hrs by WST-1 assay	[PMID: 22136433]
MOLM-13	IC₅₀	0.3 μM Compound: K00135	Growth inhibition of human MOLM13 cells after 48 hrs by WST-1 assay Growth inhibition of human MOLM13 cells after 48 hrs by WST-1 assay	[PMID: 22136433]
MV4-11	IC₅₀	0.4 μM Compound: K00135	Growth inhibition of human MV4-11 cells after 48 hrs by WST-1 assay Growth inhibition of human MV4-11 cells after 48 hrs by WST-1 assay	[PMID: 22136433]
RS4-11	IC₅₀	8.8 μM Compound: K00135	Growth inhibition of human RS4:11 cells after 48 hrs by WST-1 assay Growth inhibition of human RS4:11 cells after 48 hrs by WST-1 assay	[PMID: 22136433]
SEM	IC₅₀	6 μM Compound: K00135	Growth inhibition of human SEM cells after 48 hrs by WST-1 assay Growth inhibition of human SEM cells after 48 hrs by WST-1 assay	[PMID: 22136433]

Chemical Information

CAS No. 869650-21-5
Appearance Solid
분자량 306.36
화학식 C₁₈H₁₈N₄O
Color Light yellow to light brown
SMILES

CC(C1=CC=CC(C2=CN=C3C=CC(NCC4CC4)=NN32)=C1)=O
선적

Room temperature in continental US; may vary elsewhere.

보관

Powder	-20°C	3 years
In solvent	-80°C	6 months
	-20°C	1 month

용액&용해도

In Vitro:

DMSO : 11.67 mg/mL (38.09 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

View the Complete Stock Solution Preparation Table

Preparing Stock Solutions

View the Complete Stock Solution Preparation Table

Concentration Solvent Mass

1 mg

5 mg

10 mg

Concentration

Solvent

Mass

1 mM

3.2641 mL

16.3207 mL

32.6413 mL

5 mM

0.6528 mL

3.2641 mL

6.5283 mL

10 mM

0.3264 mL

1.6321 mL

3.2641 mL

Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

몰농도 계산기

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

농도 희석 계산기

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

순도&문서

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (269 KB)
SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Pogacic V, et al. Structural analysis identifies imidazo [1, 2-b] pyridazines as PIM kinase inhibitors with in vitro antileukemic activity[J]. Cancer research, 2007, 67(14): 6916-6924.

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Complete Stock Solution Preparation Table

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg
DMSO	1 mM	3.2641 mL	16.3207 mL	32.6413 mL	81.6033 mL
	5 mM	0.6528 mL	3.2641 mL	6.5283 mL	16.3207 mL
	10 mM	0.3264 mL	1.6321 mL	3.2641 mL	8.1603 mL
	15 mM	0.2176 mL	1.0880 mL	2.1761 mL	5.4402 mL
	20 mM	0.1632 mL	0.8160 mL	1.6321 mL	4.0802 mL
	25 mM	0.1306 mL	0.6528 mL	1.3057 mL	3.2641 mL
	30 mM	0.1088 mL	0.5440 mL	1.0880 mL	2.7201 mL

Keywords

MOQ

Minimum order quantity

100 mg

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Amount: USD 0.00

Biological Activity
- 제품 설명
Chemical Information
용액&용해도
- In Vitro
순도&문서
References

상품명:
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수량:
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K00135

MCE Bioactive Compound Library

All Pim Isoforms

Biological Activity

Chemical Information

용액&용해도

순도&문서

References

Help & FAQs

Complete Stock Solution Preparation Table

K00135 Related Classifications

HY-123141 Related Classifications