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Cat. No.: HY-186143

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KY0418

KY0418 is a selective GPX4 inhibitor. KY0418 selectively and covalently modifies the selenocysteine residue of GPX4 and inhibits GPX4 activity. KY0418 induces ferroptosis and suppresses cell proliferation. KY0418 can be used for the study of ferroptosis and cancer.

연구목적의 판매만을 진행합니다. 환자를 대상으로 한 판매는 하지 않습니다.

CAS No.: 3024369-07-8
화학식: C₂₈H₃₅F₃N₈O₃
분자량:588.62

보관:

Please store the product under the recommended conditions in the Certificate of Analysis.

KY0418 Chemical Structure

CAS No.: 3024369-07-8

Amount: USD 0.00

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- 제품 설명
- IC₅₀ & Target
- In Vitro
Chemical Information
순도&문서
References
Calculators
Help & FAQs
Classifications
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Biological Activity

제품 설명

IC₅₀ & Target

^[1]

GPX4

All Glutathione Peroxidase Isoforms :

GPX1
GPX4

In Vitro

KY0418 (E46) potently inhibits proliferation of 786-O cells with an IC₅₀ ≤ 100 nM^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Related Protocols :

Chemical Information

CAS No. 3024369-07-8
분자량 588.62
화학식 C₂₈H₃₅F₃N₈O₃
SMILES

O=C(N1C2=CC=C(N3C[C@H](C)O[C@H](C)C3)N=C2)C4(CCCC4)C5=C1N=C(COC(N6[C@@H](C(F)(F)F)CCC6)=N)N=C5N
선적

Room temperature in continental US; may vary elsewhere.
보관

Please store the product under the recommended conditions in the Certificate of Analysis.

순도&문서

Handling Instructions (2659 KB)

References

[1]. Yikai WANG, et al. Biologically active compounds and methods thereof, WO, WO2023241620A1, 2023-12-07.

Calculators

몰농도 계산기

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

농도 희석 계산기

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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MOQ

Minimum order quantity

100 mg

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Amount: USD 0.00

Biological Activity
- 제품 설명
- IC₅₀ & Target
- In Vitro
Chemical Information
순도&문서
References

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KY0418

All Glutathione Peroxidase Isoforms

Biological Activity

제품 설명

IC50 & Target

In Vitro

Chemical Information

순도&문서

References

Calculators

Help & FAQs

KY0418 Related Classifications

HY-186143 Related Classifications

Bioz

Keywords

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