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Cat. No.: HY-183282

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LC-U7-44

LC-U7-44 is a potent USP7 inhibitor with an IC₅₀of 0.96 μM. LC-U7-44 binds to the hydrophobic catalytic pocket of USP7, forming hydrogen bonds with Gln297, Arg408, Asp295, Val296, and Gln351, and hydrophobic interactions with Leu406. LC-U7-44 exerts anti-proliferative effects on prostate cancer cells. LC-U7-44 can be used for the research of prostate cancer.

연구목적의 판매만을 진행합니다. 환자를 대상으로 한 판매는 하지 않습니다.

화학식: C₂₈H₃₂N₆O₃
분자량:500.59

보관:

Please store the product under the recommended conditions in the Certificate of Analysis.

LC-U7-44 Chemical Structure

Amount: USD 0.00

* 장바구니에 담기 전 물품의 수량을 선택해 주십시오.

Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- 제품 설명
- IC₅₀ & Target
- In Vitro
Chemical Information
순도&문서
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

제품 설명

IC₅₀ & Target^[1]

USP7

0.96 μM (IC₅₀)

All Deubiquitinase Isoforms :

In Vitro

LC-U7-44 (10 μM; 20-30 min) potently inhibits purified USP7 protein with an IC₅₀ of 0.96 μM in a fluorescence polarization binding assay^[1].
LC-U7-44 potently inhibits the enzymatic activity of purified USP7 protein with an IC₅₀ of 0.46 μM in a Ub-Rho assay^[1].
LC-U7-44 (0.01-100 μM; 6 days) potently inhibits the proliferation of LNCaP cells with an IC₅₀ of 1.83 μM following 6 days of treatment^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Proliferation Assay^[1]

Cell Line:

lymph node carcinoma of the prostate (LNCaP) cells
Concentration:

0.01-100 μM
Incubation Time:

6 days
Result:

Suppressed LNCaP cell proliferation with an IC₅₀ of 1.83 μM.

Chemical Information

분자량 500.59
화학식 C₂₈H₃₂N₆O₃
SMILES

CN1N=C2C(N=CN(CC3(O)CCN(C(CCC4=CC=CC=C4)=O)CC3)C2=O)=C1C5=CC=C(CN)C=C5
선적

Room temperature in continental US; may vary elsewhere.
보관

Please store the product under the recommended conditions in the Certificate of Analysis.

순도&문서

Handling Instructions (2659 KB)

References

[1]. Chen S, et al. Development and validation of a fluorescence polarization-based assay for USP7: From probe design to inhibitor evaluation. Eur J Med Chem. 2026;312:118857. [Content Brief]

Calculators

몰농도 계산기

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

농도 희석 계산기

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

Keywords

MOQ

Minimum order quantity

100 mg

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Other size

견적 받기

Amount: USD 0.00

Biological Activity
- 제품 설명
- IC₅₀ & Target
- In Vitro
Chemical Information
순도&문서
References

상품명:
Cat. No.:
수량:
MCE Japan Authorized Agent:

상품명:
CAS No.:
Species:
Purity:
수량:

LC-U7-44

All Deubiquitinase Isoforms