Leucocyanidin
Based on 3 publication(s) in Google Scholar
Leucocyanidin is an active anti-ulcerogenic ingredient was extracted from Litchi Chinensis. Leucocyanidin demonstrates a significant protective effect against Aspirin-induced erosions in rat models.
연구목적의 판매만을 진행합니다. 환자를 대상으로 한 판매는 하지 않습니다.
- Purity: 98.0%
- CAS No.: 480-17-1
- 화학식: C15H14O7
- 분자량:306.27
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보관:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
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Publications Citing Use of MedChemExpress (MCE) Leucocyanidin
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Biological Activity
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 480-17-1
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Appearance Solid
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분자량 306.27
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화학식 C15H14O7
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Color White to light yellow
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SMILES
O[C@@H]1[C@@H](C2=CC=C(O)C(O)=C2)OC3=CC(O)=CC(O)=C3C1O
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Structure Classification
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Initial Source
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선적
Room temperature in continental US; may vary elsewhere.
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보관
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Publications (3)
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Journal Impact Factor
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Most Recent
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Nat Commun
Flavonoid pathway intermediates implicate UVR8 in functions beyond canonical UV-B signaling. [Abstract]2025 Aug 21;16(1):7810. PMID: 40841532 -
Phytomedicine
Novel dual AMPK/NRF2 activation by leucocyanidin from Hawthorn (Crataegus) for mitochondria repair-Targeted therapy of hepatic steatosis. [Abstract]2025 Nov 27:150:157614. PMID: 41365192
Leucocyanidin purchased from MedChemExpress. Usage Cited in: Phytomedicine. 2025 Nov 27:150:157614. [Abstract]
Effects of vehicle or Leucocyanidin (Leuc) (50, 100, and 150 μM) on HepG2 cells viability with or without FFA treatment within 24 h.
Leucocyanidin purchased from MedChemExpress. Usage Cited in: Phytomedicine. 2025 Nov 27:150:157614. [Abstract]
Lipid droplet deposition in FFA-treated HepG2/THLE-2 cells was assessed using Oil red O staining treated with Leucocyanidin (Leuc) (50, 100, and 150 μM).
Leucocyanidin purchased from MedChemExpress. Usage Cited in: Phytomedicine. 2025 Nov 27:150:157614. [Abstract]
MMP was measured by JC-1 staining in HepG2 cells under different treatment conditions, followed by flow cytometry treated with Leucocyanidin (Leuc) (50, 100, and 150 μM).
Leucocyanidin purchased from MedChemExpress. Usage Cited in: Phytomedicine. 2025 Nov 27:150:157614. [Abstract]
Western blotting detected CPT1 expression and quantification analysis treated with Leucocyanidin (Leuc) (50, 100, and 150 μM).
Leucocyanidin purchased from MedChemExpress. Usage Cited in: Phytomedicine. 2025 Nov 27:150:157614. [Abstract]
Representative IHC images of mice liver sections treated with Leucocyanidin (Leuc) (100, 200 mg/kg, i.g.).
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Phytomedicine
Polyphenol extract ameliorates diabetes-related atherosclerosis through HIF-1 signaling pathway in APOE-/- mice: Possible synergism with atorvastatin. [Abstract]2025 May:140:156572. PMID: 40023112
용액&용해도
DMSO : 100 mg/mL (326.51 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Select the appropriate dissolution method based on your experimental animal and administration route.
- For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
- To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
- The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: ≥ 2.5 mg/mL (8.16 mM); Clear solution
This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)
Solubility: ≥ 2.5 mg/mL (8.16 mM); Clear solution
This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.
Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
Please enter the basic information of animal experiments:
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
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%DMSO +
Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
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%+
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+%Tween-80 + +
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%Saline +
The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Working solution concentration: 0.22 mg/mL
Method for preparing stock solution: mg drug dissolved in μL DMSO. Stock solution concentration: mg/mL.
1. Take μL DMSO stock solution;
2. Add μL .
μL , mix evenly;
3. Then add μL Tween 80, mix evenly;
4. Then add μL
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
순도&문서
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Data Sheet (273 KB)
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SDS (251 KB)
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- Italian - IT (251 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 3.2651 mL | 16.3255 mL | 32.6509 mL | 81.6273 mL |
| 5 mM | 0.6530 mL | 3.2651 mL | 6.5302 mL | 16.3255 mL | |
| 10 mM | 0.3265 mL | 1.6325 mL | 3.2651 mL | 8.1627 mL | |
| 15 mM | 0.2177 mL | 1.0884 mL | 2.1767 mL | 5.4418 mL | |
| 20 mM | 0.1633 mL | 0.8163 mL | 1.6325 mL | 4.0814 mL | |
| 25 mM | 0.1306 mL | 0.6530 mL | 1.3060 mL | 3.2651 mL | |
| 30 mM | 0.1088 mL | 0.5442 mL | 1.0884 mL | 2.7209 mL | |
| 40 mM | 0.0816 mL | 0.4081 mL | 0.8163 mL | 2.0407 mL | |
| 50 mM | 0.0653 mL | 0.3265 mL | 0.6530 mL | 1.6325 mL | |
| 60 mM | 0.0544 mL | 0.2721 mL | 0.5442 mL | 1.3605 mL | |
| 80 mM | 0.0408 mL | 0.2041 mL | 0.4081 mL | 1.0203 mL | |
| 100 mM | 0.0327 mL | 0.1633 mL | 0.3265 mL | 0.8163 mL |
Leucocyanidin Related Classifications
HY-119580 Related Classifications
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