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Cat. No.: HY-124961

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LSD1-IN-2

LSD1-IN-2 is a LSD1 inhibitor with an IC₅₀ of 0.5 μM. LSD1-IN-2 increases the levels of monomethylated and dimethylated histone H3 lysine 4 (H3K4me1/2) in cells. LSD1-IN-2 reactivates epigenetically silenced tumor suppressor genes. LSD1-IN-2 can be used in the research of colon cancer.

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CAS No.: 927019-63-4
화학식: C₁₅H₃₆N₈
분자량:328.51

보관:

Please store the product under the recommended conditions in the Certificate of Analysis.

LSD1-IN-2 Chemical Structure

CAS No.: 927019-63-4

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- 제품 설명
- IC₅₀ & Target
- In Vitro
Chemical Information
순도&문서
References
Calculators
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Bioz

Biological Activity

제품 설명

IC₅₀ & Target^[1]

LSD1

0.5 μM (IC₅₀)

All Monoamine Oxidase Isoforms :

MAO-A
MAO-B

In Vitro

LSD1-IN-2 (Compound 39) potently inhibits LSD1 with an IC₅₀ of 0.5 μM^[1].
LSD1-IN-2 (0.5-10 μM) induces dose-dependent increases in H3K4me1/2 levels and tumor suppressor gene re-expression in HCT-116 colon cancer cells^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 927019-63-4
분자량 328.51
화학식 C₁₅H₃₆N₈
SMILES

N(=C(NC)NC)CCCNCCCNCCCN=C(NC)NC
선적

Room temperature in continental US; may vary elsewhere.
보관

Please store the product under the recommended conditions in the Certificate of Analysis.

순도&문서

Handling Instructions (2659 KB)

References

[1]. Decarlo D, et al. Oncoepigenomics: making histone lysine methylation count. European journal of medicinal chemistry. 2012 Oct;56:179-94. [Content Brief]

Calculators

몰농도 계산기

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

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Molecular Weight Molecular Weight

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Concentration _(start) Concentration _(start)

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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MOQ

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100 mg

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Biological Activity
- 제품 설명
- IC₅₀ & Target
- In Vitro
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LSD1-IN-2

All Monoamine Oxidase Isoforms

Biological Activity

Chemical Information

순도&문서

References

Calculators

Help & FAQs

LSD1-IN-2 Related Classifications

HY-124961 Related Classifications