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United States

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Cat. No.: HY-182348

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LSPN959

LSPN959 is a slow-acting indole peptidomimetic antiplasmodial agent with submicromolar activity against the Plasmodium falciparum 3D7 strain. LSPN959 does not inhibit plastid-dependent isoprenoid biosynthesis. The combination of LSPN959 with Artesunate (HY-N0193) exhibits an additive effect against Plasmodium falciparum. LSPN959 can be used in malaria research.

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화학식: C₃₄H₃₇BrN₄O₃
분자량:629.59

보관:

Please store the product under the recommended conditions in the Certificate of Analysis.

LSPN959 Chemical Structure

Amount: USD 0.00

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- 제품 설명
- In Vitro
Chemical Information
순도&문서
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

제품 설명

All Parasite Isoforms :

In Vitro

LSPN959 (0.049-50 μM; 72 h) potently inhibits chloroquine-sensitive Plasmodium falciparum 3D7 strain growth with an IC₅₀ of 1.05 μM, exhibits low cytotoxicity against human HepG2 and HEK293 cells, and has a high selectivity index of 95^[1].
LSPN959 (0.049-50 μM; 24-72 h) exhibits a slow-acting inhibitory profile against Plasmodium falciparum 3D7 strain, with IC₅₀ ratios and morphological observations consistent with delayed parasite killing and recovery potential post-exposure^[1].
LSPN959 (72 h)'s antiplasmodial activity against Plasmodium falciparum 3D7 strain is not reversed by IPP supplementation, indicating it does not inhibit apicoplast-dependent isoprenoid biosynthesis^[1].
LSPN959 (72 h) exhibits an additive interaction when combined with Artesunate against Plasmodium falciparum 3D7 strain, with no statistically significant synergy or antagonism observed^[1].
LSPN959 (0.049-50 μM; 72 h) retains potent antiplasmodial activity against multidrug-resistant Plasmodium falciparum strains (3D7^R_MMV848, Dd2R_DSM265, Dd2, K1, TM90C6B) with resistance indices close to 1, showing no cross-resistance with standard antimalarials^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. .

Chemical Information

분자량 629.59
화학식 C₃₄H₃₇BrN₄O₃
SMILES

CC(C)(NC(CN(C(C1=CC=CC=C1)=O)CC(C2=CC3=CC=CC=C3N2C(N4CCCC4)=O)C5=CC=C(C=C5)Br)=O)C
선적

Room temperature in continental US; may vary elsewhere.
보관

Please store the product under the recommended conditions in the Certificate of Analysis.

순도&문서

Handling Instructions (2659 KB)

References

[1]. Januário MA, et al. Indole Peptidomimetics Show Potent and Selective Activity against Drug-Resistant Plasmodium falciparum. ACS Omega. 2026 Mar 21.

Calculators

몰농도 계산기

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

농도 희석 계산기

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

Keywords

MOQ

Minimum order quantity

100 mg

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