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Cat. No.: HY-P11736

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mcIRBP-9

mcIRBP-9 is an orally active NF-κB inhibitor. mcIRBP-9 reduces the levels of TNF-α, IL-1β and TGF-β1 in renal tissues, and decreases LPS-induced IL-1β production. mcIRBP-9 can be used in research related to diabetic nephropathy and type 2 diabetes mellitus.

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CAS No.: 1489241-80-6
화학식: C₄₂H₇₄N₁₂O₁₁
분자량:923.11

보관:

Please store the product under the recommended conditions in the Certificate of Analysis.

mcIRBP-9 Chemical Structure

CAS No.: 1489241-80-6

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity

제품 설명

All NF-κB Isoforms :

In Vivo

mcIRBP-9 (1-10 μmol kg^?1; p.o.; once daily or single dose; 12 consecutive weeks or short-term) improves glucose clearance in a dose-dependent manner, reduces long-term blood glucose and HbA1c levels, improves survival rate to 100%, and ameliorates diabetic nephropathy in db/db mice via anti-inflammatory and reno-protective effects^[1].
mcIRBP-9 (1 μmol kg^?1; p.o.; single dose given after LPS challenge) suppresses LPS-induced renal NF-κB activity and systemic IL-1β production in NF-κB transgenic mice, demonstrating anti-inflammatory activity relevant to nephropathy^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

NF-κB transgenic (male, 6-week-old)^[1]
Dosage:

1 μmol kg^-1
Administration:

p.o.; single dose given after LPS challenge
Result:

Reduced serum IL-1β levels by 69.28 % compared to LPS-only controls.
Suppressed LPS-induced renal NF-κB-dependent luminescent intensities by 61.78 % compared to LPS-only controls.

Chemical Information

CAS No. 1489241-80-6
분자량 923.11
화학식 C₄₂H₇₄N₁₂O₁₁
Sequence

Ile-Val-Ala-Arg-Pro-Pro-Thr-Ile-Gly
Sequence Shortening

IVARPPTIG
선적

Room temperature in continental US; may vary elsewhere.
보관

Please store the product under the recommended conditions in the Certificate of Analysis.

순도&문서

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (260 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Pei-Yung Liao, et al. A gastro-resistant peptide from Momordica charantia improves diabetic nephropathy in db/db mice via its novel reno-protective and anti-inflammatory activities. Cite this: Food Funct., 2022, 13, 1822.

Calculators

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Molecular Weight Molecular Weight

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

100 mg

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Amount: USD 0.00

Biological Activity
- 제품 설명
- In Vivo
Chemical Information
순도&문서
References

상품명:
Cat. No.:
수량:
MCE Japan Authorized Agent:

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CAS No.:
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mcIRBP-9

All NF-κB Isoforms

Biological Activity

Chemical Information

순도&문서

References

Calculators

Help & FAQs

mcIRBP-9 Related Classifications

HY-P11736 Related Classifications