MEN 10207
Based on 1 publication(s) in Google Scholar
MEN 10207 is a selective NK-2 tachykinin receptor (Neurokinin Receptor) antagonist. MEN 10207 has pA2 values of 5.2, 7.9 and 4.9 in three monoreceptor in vitro assays for NK-1, NK-2 and NK-3 tachykinin receptors, respectively.
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- Purity: 99.80%
- CAS No.: 126050-12-2
- 화학식: C57H68N14O10
- 분자량:1109.24
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보관:
Sealed storage, away from moisture and light, under nitrogen.
Powder -80°C, 2 years , -20°C, 1 year* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light, under nitrogen)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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용액&용해도
- 순도&문서
- References
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Help & FAQs
Publications Citing Use of MedChemExpress (MCE) MEN 10207
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Biological Activity
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Tachykinin NK2 Receptor 7.9 (pA2) |
NK1R 5.2 (pA2) |
NK3R 4.9 (pA2) |
In competitive radioligand binding assays, MEN 10207 (the IC50 ranges of 21-54 nM) has high affinity in bovine stomach membranes and SKLKB82#3 cells, a murine fibroblast cell line transfected with a cDNA encoding for the bovine NK2 receptor[3].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Decerebrate, spinalized, unanesthetized Female Sprague-Dawley rats (250-280 g)[1]
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Dosage:7 pmol/10 μL, 70 pmol/10 μL, 700 pmol/10 μL
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Administration:Intrathecal administration; once
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Result:Blocked the reflex facilitation to intrathecal Neurokinin A, but not Substance P in a dose-dependent manner.
Chemical Information
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CAS No. 126050-12-2
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Appearance Solid
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분자량 1109.24
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화학식 C57H68N14O10
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Color White to off-white
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선적
Room temperature in continental US; may vary elsewhere.
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보관
Sealed storage, away from moisture and light, under nitrogen
Powder -80°C 2 years -20°C 1 year * In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light, under nitrogen)
Publications (1)
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Journal Impact Factor
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Most Recent
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EMBO Mol Med
Reelin-LRP8 signaling mediates brain dissemination of breast cancer cells via abluminal migration. [Abstract]2025 Jun 12. PMID: 40506610
용액&용해도
DMSO : 50 mg/mL (45.08 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light, under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light, under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
순도&문서
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Data Sheet (277 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
References
[1]. X J Xu, et al. On the role of NK-2 tachykinin receptors in the mediation of spinal reflex excitability in the rat. Neuroscience. 1991;44(2):483-90. [Content Brief]
[2]. P Rovero, et al. A highly selective NK-2 tachykinin receptor antagonist containing D-tryptophan. Eur J Pharmacol. 1990 Jan 3;175(1):113-5. [Content Brief]
[3]. A K Henderson, et al. Demonstration of a neurokinin A receptor subtype in transfected fibroblasts. Eur J Pharmacol. 1992 Feb 13;225(2):175-8. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light, under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 0.9015 mL | 4.5076 mL | 9.0152 mL | 22.5380 mL |
| 5 mM | 0.1803 mL | 0.9015 mL | 1.8030 mL | 4.5076 mL | |
| 10 mM | 0.0902 mL | 0.4508 mL | 0.9015 mL | 2.2538 mL | |
| 15 mM | 0.0601 mL | 0.3005 mL | 0.6010 mL | 1.5025 mL | |
| 20 mM | 0.0451 mL | 0.2254 mL | 0.4508 mL | 1.1269 mL | |
| 25 mM | 0.0361 mL | 0.1803 mL | 0.3606 mL | 0.9015 mL | |
| 30 mM | 0.0301 mL | 0.1503 mL | 0.3005 mL | 0.7513 mL | |
| 40 mM | 0.0225 mL | 0.1127 mL | 0.2254 mL | 0.5634 mL |
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