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United States

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Cat. No.: HY-177732

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MG-Lin2

MG-Lin2 is a Lin28 molecular glue degrader. It induces the formation of a ternary complex between Lin28 and the E3 ubiquitin ligase RNF126, mediates the degradation of Lin28 via the ubiquitin-proteasome pathway, and restores the abundance and function of mature let-7 miRNA. MG-Lin2 can be used in studies of ovarian cancer and choriocarcinoma.

연구목적의 판매만을 진행합니다. 환자를 대상으로 한 판매는 하지 않습니다.

화학식: C₂₉H₂₇F₃N₆O₂
분자량:548.56

보관:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (264 KB)

MG-Lin2 Chemical Structure

Amount: USD 0.00

* 장바구니에 담기 전 물품의 수량을 선택해 주십시오.

Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- 제품 설명
- In Vitro
Chemical Information
순도&문서
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

제품 설명

In Vitro

MG-Lin2 (0.1-100 μM; 24 h) showed
a proper dose-response relationship, with a significant reduction in luciferase intensity at 0.1 μM.^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. .

Chemical Information

분자량 548.56
화학식 C₂₉H₂₇F₃N₆O₂
SMILES

CC1=NN=C2C=CC(C3=CC=CC(N(C(C4CCN(CC4)C(/C=C/C5=CC=C(C=C5)C(F)(F)F)=O)=O)C)=C3)=NN12
선적

Room temperature in continental US; may vary elsewhere.
보관

Please store the product under the recommended conditions in the Certificate of Analysis.

순도&문서

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (264 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Kashkush A, et al. PROTAC and Molecular Glue Degraders of the Oncogenic RNA Binding Protein Lin28. Macromolecular bioscience. 2025 Mar;25(3):e2400427. [Content Brief]

Calculators

몰농도 계산기

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

농도 희석 계산기

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

Keywords

MOQ

Minimum order quantity

100 mg

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