MK-4882
MK-4882 is an HCV NS5A inhibitor with activity in reducing viral load in a chimpanzee model of HCV infection, but with issues of viral breakthrough, prompting the development of compounds with greater potency against more genotypes and NS5A resistance mutations.
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- CAS No.: 1246470-32-5
- 화학식: C42H50N8O7
- 분자량:778.90
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보관:
Please store the product under the recommended conditions in the Certificate of Analysis.
Biological Activity
|
Cell Line
|
Type | Value | Description | References |
|---|---|---|---|---|
| Huh-7 | CC50 |
7 μM
Compound: MK-4882
|
Cytotoxicity in human HuH7 replicon cells by MTS assay
Cytotoxicity in human HuH7 replicon cells by MTS assay
|
[PMID: 29653894] |
Chemical Information
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CAS No. 1246470-32-5
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분자량 778.90
-
화학식 C42H50N8O7
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SMILES
O=C(N[C@@H](C(C)C)C(N1[C@@H](CCC1)C2=NC=C(N2)C3=CC=C(C=C3)C4=CC5=CC(C6=CN=C(N6)[C@H]7N(CCC7)C([C@H](C(C)C)NC(OC)=O)=O)=CC=C5O4)=O)OC
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선적
Room temperature in continental US; may vary elsewhere.
-
보관
Please store the product under the recommended conditions in the Certificate of Analysis.
순도&문서
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)