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Cat. No.: HY-100230

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ML-133

3 Cited Publications

고객리뷰

Based on 3 publication(s) in Google Scholar

ML133 is a selective K_ir2 family channels inhibitor, with an IC₅₀ of 1.8 μM at pH 7.4 and 290 nM at pH 8.5.

연구목적의 판매만을 진행합니다. 환자를 대상으로 한 판매는 하지 않습니다.

CAS No.: 185669-79-8
화학식: C₁₉H₁₉NO
분자량:277.36

보관:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (269 KB)

ML-133 Chemical Structure

CAS No.: 185669-79-8

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- 제품 설명
- IC₅₀ & Target
- Cellular Effect
Chemical Information
Publications (3)
순도&문서
References
Calculators
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Bioz

Biological Activity

제품 설명

ML133 is a selective K_ir2 family channels inhibitor, with an IC₅₀ of 1.8 μM at pH 7.4 and 290 nM at pH 8.5^[1].

IC₅₀ & Target

IC50: 1.8 μM (K_ir2 at pH 7.4), 290 nM (K_ir2 at pH 8.5)^[1].

Cellular Effect

Cell Line	Type	Value	Description	References
HEK293	IC₅₀	1.8 μM Compound: 162, ML133	Inhibition of mouse Kir2.1 expressed in HEK293 cells by patch clamp technique Inhibition of mouse Kir2.1 expressed in HEK293 cells by patch clamp technique	[PMID: 23121096]

Chemical Information

CAS No. 185669-79-8
분자량 277.36
화학식 C₁₉H₁₉NO
SMILES

COC1=CC=C(CNCC2=C3C=CC=CC3=CC=C2)C=C1
선적

Room temperature in continental US; may vary elsewhere.
보관

Please store the product under the recommended conditions in the Certificate of Analysis.

Publications (3)

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Journal Impact Factor

Cell Metab

Tumor-associated macrophages are shaped by intratumoral high potassium via Kir2.1. [Abstract]

2022 Nov 1;34(11):1843-1859.e11. PMID: 36103895
Pharmacol Res

Pharmacological inhibition of Kv1.3 channel impairs TLR3/4 activation and type I IFN response and confers protection against Listeria monocytogenes infection. [Abstract]

2022 Feb 2;177:106112. PMID: 35122955
Cell Death Dis

Pictilisib and nutrient stress synergize to induce methuosis via PI(4,5)P2-dependent macropinocytic dysregulation in cancer cells. [Abstract]

2026 Jun 16. PMID: 42303628

순도&문서

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (269 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Wang HR, et al. Selective inhibition of the K(ir)2 family of inward rectifier potassium channels by a small molecule probe: the discovery, SAR, and pharmacological characterization of ML133. ACS Chem Biol. 2011 Aug 19;6(8):845-56. [Content Brief]

Calculators

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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MOQ

Minimum order quantity

100 mg

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Biological Activity
- 제품 설명
- IC₅₀ & Target
Chemical Information
Publications (3)
순도&문서
References

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ML-133

Publications Citing Use of MedChemExpress (MCE) ML-133