MM3122
Based on 1 Customer Validation
MM3122 is a selective type II transmembrane serine protease (TMPRSS2) inhibitor with an IC50 value of 0.34 nM. MM3122 effectively blocks TMPRSS2, thereby inhibiting the entry of SARS-CoV-2 and MERS-CoV into human cells.
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- Purity : 99.11%
- CAS No.: 2574390-27-3
- 화학식: C31H39N9O6S
- 분자량:665.76
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보관:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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용액&용해도
- 순도&문서
- References
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Help & FAQs
Biological Activity
제품 설명
In Vitro
MM3122 (0-1 μM) has inhibitory activity against HGFA, matriptase, hepsin and thrombin with the IC50 values of 32, 0.31, 0.19 and more than 20 nM, respectively[1].
MM3122 (0.1-100 μM) inhibits SARS-CoV-2 calu-3, VSV-SARS CoV-2 chimera calu-3 and MERS VSV pseudotype calu-3 with the EC50 values of 74, 0.43 and 0.87 nM, respectively[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
In Vivo
MM3122 (i.p., 16.7 mg/kg, once) has a half-life of 8.6 hours in plasma and 7.5 hours in lung of NSG mice[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 2574390-27-3
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Appearance Solid
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분자량 665.76
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화학식 C31H39N9O6S
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Color White to off-white
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SMILES
CC(NCC(N[C@@H](CCC(N)=O)C(N[C@@H](CC1=CC=CC=C1)C(N[C@@H](CCCNC(N)=N)C(C2=NC3=CC=CC=C3S2)=O)=O)=O)=O)=O
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선적
Room temperature in continental US; may vary elsewhere.
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보관
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
용액&용해도
In Vitro:
DMSO : 125 mg/mL (187.76 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
순도&문서
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Data Sheet (273 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 1.5020 mL | 7.5102 mL | 15.0204 mL | 37.5511 mL |
| 5 mM | 0.3004 mL | 1.5020 mL | 3.0041 mL | 7.5102 mL | |
| 10 mM | 0.1502 mL | 0.7510 mL | 1.5020 mL | 3.7551 mL | |
| 15 mM | 0.1001 mL | 0.5007 mL | 1.0014 mL | 2.5034 mL | |
| 20 mM | 0.0751 mL | 0.3755 mL | 0.7510 mL | 1.8776 mL | |
| 25 mM | 0.0601 mL | 0.3004 mL | 0.6008 mL | 1.5020 mL | |
| 30 mM | 0.0501 mL | 0.2503 mL | 0.5007 mL | 1.2517 mL | |
| 40 mM | 0.0376 mL | 0.1878 mL | 0.3755 mL | 0.9388 mL | |
| 50 mM | 0.0300 mL | 0.1502 mL | 0.3004 mL | 0.7510 mL | |
| 60 mM | 0.0250 mL | 0.1252 mL | 0.2503 mL | 0.6259 mL | |
| 80 mM | 0.0188 mL | 0.0939 mL | 0.1878 mL | 0.4694 mL | |
| 100 mM | 0.0150 mL | 0.0751 mL | 0.1502 mL | 0.3755 mL |
MM3122 Related Classifications
HY-148072 Related Classifications
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