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Cat. No.: HY-188585

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MP-Ala-Ala

MP-Ala-Ala is a protease-cleavable ADC Linker. MP-Ala-Ala can be stably conjugated to cysteine residues of targeting antibodies (such as anti-CD19 antibodies or anti-TNF antibodies). MP-Ala-Ala accelerates the hydrolysis and ring opening of the succinimide ring via MP to stabilize the antibody conjugation, and after entering the lysosome of target cells, the Ala-Ala dipeptide is cleaved by proteases, thereby targeting the release of the active payload to exert anti-inflammatory effects and reduce systemic toxicity. MP-Ala-Ala can be used in research on inflammatory and immune diseases.

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CAS No.: 3014393-33-7
화학식: C₁₃H₁₇N₃O₆
분자량:311.29

보관:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (277 KB)

MP-Ala-Ala Chemical Structure

CAS No.: 3014393-33-7

Amount: USD 0.00

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Biological Activity
- 제품 설명
- In Vitro
Chemical Information
순도&문서
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

제품 설명

All ADC Linkers Isoforms :

In Vitro

MP-Ala-Ala can be used to construct anti-CD19 ADCs (such as ADC6 and ADC23)^[2].
MP-Ala-Ala can be used to construct anti-TNF ADCs (such as ADC39/ABBV-3373)^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Related Protocols :

Chemical Information

CAS No. 3014393-33-7
분자량 311.29
화학식 C₁₃H₁₇N₃O₆
SMILES

O=C(N[C@@H](C)C(O)=O)[C@@H](NC(CCN1C(C=CC1=O)=O)=O)C
선적

Room temperature in continental US; may vary elsewhere.
보관

Please store the product under the recommended conditions in the Certificate of Analysis.

순도&문서

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (277 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Hobson AD, et al. Discovery of ABBV-3373, an Anti-TNF Glucocorticoid Receptor Modulator Immunology Antibody Drug Conjugate. Journal of medicinal chemistry. 2022 Dec 08;65(23):15893-15934. [Content Brief]

[2]. Marvin CC, et al. Self-Immolative Carbamate Linkers for CD19-Budesonide Antibody-Drug Conjugates. Bioconjug Chem. 2023 Oct 18;34(10):1835-1850. [Content Brief]

[3]. Hobson AD. The medicinal chemistry evolution of antibody-drug conjugates. RSC Med Chem. 2024 Feb 28;15(3):809-831.

Calculators

몰농도 계산기

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

농도 희석 계산기

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

Keywords

MOQ

Minimum order quantity

100 mg

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