MYBMIM
Based on 1 Customer Validation
MYBMIM is an inhibitor for assembly of the molecular MYB:CBP/P300 complex. MYBMIM inhibits growth of leukemia cells.
연구목적의 판매만을 진행합니다. 환자를 대상으로 한 판매는 하지 않습니다.
- Purity: 99.96%
- 화학식: C166H296N60O45S
- 분자량:3884.57
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보관:
Sealed storage, away from moisture.
Powder -80°C, 2 years , -20°C, 1 year* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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용액&용해도
- 순도&문서
- References
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Help & FAQs
Biological Activity
MYBMIM (10-20 μM) inhibits proliferation (6 days) and induces apoptosis (48 h) in acute myeloid leukemia cells by downregulating anti-apoptotic Bcl2 gene expression[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:MOLM-13, MV-411, ML2, and HL60
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Concentration:10-20 μM
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Incubation Time:6 days
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Result:Inhibited cell viability.
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Cell Line:MV-411
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Concentration:20 μM
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Incubation Time:4 h
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Result:Induced cell apoptosis.
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Cell Line:MOLM-13, MV-411, ML2, and HL60
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Concentration:10-20 μM
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Incubation Time:6 h
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Result:Downregulated levels of Bcl2
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:AML-MLL- leukemia xenograft mice model[1]
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Dosage:25 mg/kg
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Administration:ip, twice a day for 14 days
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Result:Delayed leukemia progression and extended survival.
Chemical Information
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Appearance Solid
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분자량 3884.57
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화학식 C166H296N60O45S
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Color White to off-white
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Sequence
Ac-d-{Lys-Leu-Glu-Asn-Glu-Thr-Ser-Met-Leu-Leu-Leu-Glu-Leu-Glu-Lys-Ile-Arg-Lys-Gly-Gly-Arg-Arg-Arg-Gln-Arg-Arg-Lys-Lys-Arg-Gly-Tyr}-NH2
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Sequence Shortening
Ac-d-{KLENETSMLLLELEKIRKGG-RRRQRRKKRGY}-NH2
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선적
Room temperature in continental US; may vary elsewhere.
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보관
Sealed storage, away from moisture
Powder -80°C 2 years -20°C 1 year * In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
용액&용해도
H2O : ≥ 50 mg/mL (12.87 mM)
* "≥" means soluble, but saturation unknown.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
순도&문서
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Data Sheet (282 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| H2O | 1 mM | 0.2574 mL | 1.2871 mL | 2.5743 mL | 6.4357 mL |
| 5 mM | 0.0515 mL | 0.2574 mL | 0.5149 mL | 1.2871 mL | |
| 10 mM | 0.0257 mL | 0.1287 mL | 0.2574 mL | 0.6436 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
MYBMIM Related Classifications
HY-P10238 Related Classifications
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