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Cat. No.: HY-162944

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NA-Ir

NA-Ir is a Ferroptosis inducer. NA-Ir targets mitochondrial DNA (mtDNA) and activates the cGAS-STING pathway to induce ferritinophagy (Autophagy), while also generating reactive oxygen species (ROS) through photodynamic therapy (PDT), depleting glutathione (GSH), and downregulating glutathione peroxidase 4 (GPX4), thereby triggering lipid peroxidation and Ferroptosis. NA-Ir exhibits higher anticancer activity under light exposure and selectively inhibits cancer cells with high H₂S levels.

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CAS No.: 3031762-97-4
화학식: C₄₉H₃₆F₆IrN₈O₄P
분자량:1138.04

보관:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (271 KB)

NA-Ir Chemical Structure

CAS No.: 3031762-97-4

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity

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Chemical Information

CAS No. 3031762-97-4
분자량 1138.04
화학식 C₄₉H₃₆F₆IrN₈O₄P
SMILES

CC1=CC2=[N](C=C1)[Ir+3]34([C-]5=C(C=CC=C5)C6=CC=CC=[N]63)([C-]7=CC=CC=C7C8=[N]4C=CC=C8)[N]9=CC=C(COC(CCN%10C(C%11=C%12C(C%10=O)=CC=C(C%12=CC=C%11)N=[N+]=[N-])=O)=O)C=C29.[F-][P+5]([F-])([F-])([F-])([F-])[F-]
선적

Room temperature in continental US; may vary elsewhere.
보관

Please store the product under the recommended conditions in the Certificate of Analysis.

순도&문서

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Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (271 KB)
SDS (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Li Y, et al. Photoinduction of Ferroptosis and cGAS-STING Activation by a H2S-Responsive Iridium(III) Complex for Cancer-Specific Therapy. J Med Chem. 2024 Sep 26;67(18):16235-16247. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

100 mg

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