country

Change Language

EN - English
FR - Français
DE - Deutsch
ES - Español
JA - 日本語
KO - 한국어

Country or Region:

United States

Product Name	Size / Unit Price	Qty

Total: USD 0.00 Checkout

Cat. No.: HY-150965

Copy Link Print Information

NDT-30805

NDT-30805 is a selective NLRP3 inflammasome inhibitor. NDT-30805 is a triazolopyrimidinone derivative and inhibits IL-1β release in PBMCs with an IC₅₀ of 0.013 μM. NDT-30805 can be used for the research of inflammation and innate immunity.

연구목적의 판매만을 진행합니다. 환자를 대상으로 한 판매는 하지 않습니다.

화학식: C₂₃H₂₂N₆S
분자량:414.53

보관:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (273 KB)

NDT-30805 Chemical Structure

사이즈

가격

재고

수량

Amount: USD 0.00

* 장바구니에 담기 전 물품의 수량을 선택해 주십시오.

Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- 제품 설명
- IC₅₀ & Target
- Cellular Effect
- In Vitro
Chemical Information
순도&문서
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

제품 설명

IC₅₀ & Target

NLRP3

NLRP3 inflammasome

All NOD-like Receptor (NLR) Isoforms :

Cellular Effect

Cell Line	Type	Value	Description	References
PBMC	IC₅₀	>40 μM Compound: 50;NDT-30805	Inhibition of LPS-stimulated IL-6 release in human PBMC measured after 4 hrs by ELISA Inhibition of LPS-stimulated IL-6 release in human PBMC measured after 4 hrs by ELISA	[PMID: 35978696]
PBMC	IC₅₀	>40 μM Compound: 50;NDT-30805	Inhibition of LPS-stimulated TNF-alpha release in human PBMC measured after 4 hrs by ELISA Inhibition of LPS-stimulated TNF-alpha release in human PBMC measured after 4 hrs by ELISA	[PMID: 35978696]

In Vitro

NDT-30805 (0-2 μM; 30 min) inhibits IL-1β release in PBMCs^[1].
NDT-30805 (0-2 μM; 30 min) inhibits ASC speck formation in THP1-ASC-GFP cells^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay^[1]

Cell Line:

Human PBMCs
Concentration:

0-2 μM
Incubation Time:

30 min
Result:

Inhibited IL-1β release in PBMCs with an IC₅₀ of 0.013 μM.

Cell Viability Assay^[1]

Cell Line:

THP1-ASC-GFP cells
Concentration:

0-2 μM
Incubation Time:

30 min
Result:

Inhibited ASC which is a component of NLRP3 inflammasome in PBMCs with an IC₅₀ of 0.034 μM.

Chemical Information

분자량 414.53
화학식 C₂₃H₂₂N₆S
SMILES

S=C1C=C(CC2=NC=CC=C2)NC3=NC(NC4=C5CCCC5=CC6=C4CCC6)=NN13
선적

Room temperature in continental US; may vary elsewhere.
보관

Please store the product under the recommended conditions in the Certificate of Analysis.

순도&문서

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (273 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. David H, et al. Discovery and Optimization of Triazolopyrimidinone Derivatives as Selective NLRP3 Inflammasome Inhibitors. ACS Medicinal Chemistry Letters. 2022. [Content Brief]

Calculators

몰농도 계산기

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

농도 희석 계산기

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

MOQ

Minimum order quantity

100 mg

견적 받기 해외재고보유

Other size

견적 받기

Amount: USD 0.00

Biological Activity
- 제품 설명
- IC₅₀ & Target
- In Vitro
Chemical Information
순도&문서
References

상품명:
Cat. No.:
수량:
MCE Japan Authorized Agent:

상품명:
CAS No.:
Species:
Purity:
수량:

NDT-30805

All NOD-like Receptor (NLR) Isoforms

Biological Activity

Chemical Information

순도&문서

References

Calculators

Help & FAQs

NDT-30805 Related Classifications

HY-150965 Related Classifications