Neomycin C
Neomycin C is an impurity of Neomycin (HY-150520) and a stereoisomer of Neomycin B (HY-17624). Neomycin C exerts in vitro antimicrobial activity against Staphylococcus epidermidis and Staphylococcus aureus. Neomycin C can be used for the research of bacterial infection.
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- CAS No.: 66-86-4
- 화학식: C23H46N6O13
- 분자량:614.64
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보관:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Protocol
- 순도&문서
- References
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Help & FAQs
Biological Activity
제품 설명
IC50 & Target
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Aminoglycoside |
In Vitro
Chemical Information
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CAS No. 66-86-4
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분자량 614.64
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화학식 C23H46N6O13
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SMILES
N[C@@H]1[C@@H](O[C@@H]2[C@H](N)[C@@H](O)[C@H](O)[C@@H](CN)O2)[C@H](O[C@H]3[C@H](O)[C@H](O[C@@H]4[C@H](N)[C@@H](O)[C@H](O)[C@@H](CN)O4)[C@@H](CO)O3)[C@@H](O)[C@H](N)C1
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선적
Room temperature in continental US; may vary elsewhere.
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보관
Please store the product under the recommended conditions in the Certificate of Analysis.
Protocol
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Research Protocol for Infectious Diseases
Infectious-disease experiments test how pathogens interact with host barriers, innate immune receptors, inflammatory signaling, pathogen replication, and tissue injury; pattern-recognition receptors such as TLRs, RIG-I-like receptors, NOD-like receptors, and inflammasomes detect microbial molecules and activate NF-κB, interferon, and cytokine responses. The central hypothesis is that infection severity reflects the balance between pathogen burden and host response: protective inflammation restricts pathogen growth, whereas excessive or mislocalized inflammation contributes to tissue damage and disease phenotype. Unresolved questions include which host pathways are protective versus pathogenic, why some infection models fail to translate to human disease, and which combined readouts best predict clinically relevant infection outcomes.
순도&문서
References
[1]. Robertson JH, et al. Antimicrobial activity of neomycin C against Staphylococcus epidermidis. Appl Microbiol. 1971;22(6):1164-1165. [Content Brief]
[2]. Zheng J, et al. Component Optimization of Neomycin Biosynthesis via the Reconstitution of a Combinatorial Mini-Gene-Cluster in Streptomyces fradiae. ACS Synth Biol. 2020 Sep 18;9(9):2493-2501. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Neomycin C Related Classifications
HY-131130 Related Classifications
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