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Cat. No.: HY-119534

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Nicothiazone

Nicothiazone is an α-glucosidase inhibitor with a yeast α-glucosidase IC₅₀ of 120.20 μM. Nicothiazone inhibits α-glucosidase enzyme activity. Nicothiazone can be used for the research of type-II diabetes mellitus.

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CAS No.: 555-90-8
화학식: C₇H₈N₄S
분자량:180.23

보관:

Please store the product under the recommended conditions in the Certificate of Analysis.

Nicothiazone Chemical Structure

CAS No.: 555-90-8

Amount: USD 0.00

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- 제품 설명
- IC₅₀ & Target
- In Vitro
Chemical Information
순도&문서
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

제품 설명

IC₅₀ & Target^[1]

α‑glucosidase

120.20 μM (IC₅₀)

In Vitro

Nicothiazone (compound 1) (10 min pre-incubation; 30 min reaction incubation) potently inhibits Baker's yeast α-glucosidase with an IC₅₀ of 120.20 μM, showing greater potency than Acarbose (HY-B0089)^[1].
Nicothiazone interacts with Saccharomyces cerevisiae α-glucosidase via hydrogen bonding with residues Asp349 and His111, supporting its inhibitory activity^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 555-90-8
분자량 180.23
화학식 C₇H₈N₄S
SMILES

S=C(N)NN=CC=1C=NC=CC1
선적

Room temperature in continental US; may vary elsewhere.
보관

Please store the product under the recommended conditions in the Certificate of Analysis.

순도&문서

Handling Instructions (2659 KB)

References

[1]. Ali F, et al. Hydrazinyl arylthiazole based pyridine scaffolds: Synthesis, structural characterization, in vitro α-glucosidase inhibitory activity, and in silico studies. European journal of medicinal chemistry. 2017 Sep 29;138:255-272. [Content Brief]

Calculators

몰농도 계산기

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

농도 희석 계산기

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

Keywords

MOQ

Minimum order quantity

100 mg

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