country

Change Language

EN - English
FR - Français
DE - Deutsch
ES - Español
JA - 日本語
KO - 한국어

Country or Region:

United States

Product Name	Size / Unit Price	Qty

Total: USD 0.00 Checkout

Cat. No.: HY-189733

Copy Link Print Information

NK037

NK037 is a phthalimide derivative that exhibits multi-target enzyme inhibitory activity against urease, xanthine oxidase, and butyrylcholinesterase (BChE). NK037 inhibits urease with IC₅₀ = 2.9 μM, xanthine oxidase with IC₅₀ = 5.61 μM, and butyrylcholinesterase with IC₅₀ = 9.49 μM. NK037 can form enzyme-ligand complexes with urease, xanthine oxidase, and thymidine phosphorylase. Urease-IN-26 can be used for metabolism-related research.

연구목적의 판매만을 진행합니다. 환자를 대상으로 한 판매는 하지 않습니다.

CAS No.: 60945-03-1
화학식: C₁₅H₈N₂O₂S
분자량:280.30

보관:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (282 KB)

NK037 Chemical Structure

CAS No.: 60945-03-1

Amount: USD 0.00

* 장바구니에 담기 전 물품의 수량을 선택해 주십시오.

Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- 제품 설명
- IC₅₀ & Target
- In Vitro
Chemical Information
순도&문서
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

제품 설명

IC₅₀ & Target

^[1]

BChE

9.49 μM (IC₅₀)

All Cholinesterase (ChE) Isoforms :

AChE
BChE

In Vitro

NK037 (compound C15) (0.156-5 mM) inhibits jack bean urease in the indophenol colorimetric assay with an IC₅₀ of 2.90 μM; inhibits Escherichia coli thymidine phosphorylase in the thymidine substrate assay with an IC₅₀ of 17.81 μM; inhibits bovine milk xanthine oxidase with an IC₅₀ of 5.61 μM; inhibits horse serum butyrylcholinesterase with an IC₅₀ of 9.49 μM^[1].
NK037 (1‑8 μM) can bind to jack bean urease, bovine milk xanthine oxidase, and Escherichia coli thymidine phosphorylase, with dissociation constants K_d of 0.04 μM, 0.12 μM, and 0.49 μM, respectively, and binding constants K_b of 26.97 μM^-1, 8.44 μM^-1, and 2.03 μM^-1, respectively^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 60945-03-1
분자량 280.30
화학식 C₁₅H₈N₂O₂S
SMILES

O=C1N(C2=NC3=C(C=CC=C3)S2)C(C4=CC=CC=C41)=O
선적

Room temperature in continental US; may vary elsewhere.
보관

Please store the product under the recommended conditions in the Certificate of Analysis.

순도&문서

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (282 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Khushal A, et al. Synthesis, multi-target enzyme inhibition, and in silico evaluation of phthalimide derivatives with relevance to tuberculosis-associated pathophysiology. Bioorganic chemistry. 2026 Aug 31;182:110441.

Calculators

몰농도 계산기

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

농도 희석 계산기

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

MOQ

Minimum order quantity

100 mg

견적 받기 해외재고보유

Other size

견적 받기

Amount: USD 0.00

Biological Activity
- 제품 설명
- IC₅₀ & Target
- In Vitro
Chemical Information
순도&문서
References

상품명:
Cat. No.:
수량:
MCE Japan Authorized Agent:

상품명:
CAS No.:
Species:
Purity:
수량:

NK037

All Cholinesterase (ChE) Isoforms