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Cat. No.: HY-185010

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nor-MC3

Name: nor-MC3
Brand: MedChemExpress
SKU: HY-185010
Price: 246.00 USD
Availability: InStock
Rating: 5 (1 reviews)

고객리뷰

Based on 1 Customer Validation

nor-MC3 is an MC3-type ionizable lipid with C₁₇ unsaturated chains, formulated in lipid nanoparticles for nucleic acid (mRNA and siRNA) delivery and supports in vitro and in vivo transfection.

연구목적의 판매만을 진행합니다. 환자를 대상으로 한 판매는 하지 않습니다.

CAS No.: 2870681-06-2
화학식: C₄₁H₇₅NO₂
분자량:614.04

보관:

Solution, -20°C, 2 years

Data Sheet (263 KB)

nor-MC3 Chemical Structure

CAS No.: 2870681-06-2

사이즈

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- 제품 설명
- In Vitro
- In Vivo
Chemical Information
순도&문서
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

제품 설명

All Melanocortin Receptor Isoforms :

In Vitro

nor-MC3-based mRNA LNPs (0.03-10 μg/mL mRNA; 24 h) exhibit superior in vitro transfection efficiency in HuH7 cells compared to MC3-based LNPs, with enhanced activity at 10 μg/mL mRNA^[1].
nor-MC3-based siRNA LNPs (0.03-1 μg/mL siRNA) exhibit comparable in vitro knockdown efficiency in stably luciferase-expressing 22Rv1 cells to MC3-based LNPs, with enhanced activity at 0.5 μg/mL siRNA and a similar EC₅₀ value of 0.1644 μg/mL siRNA^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Nor-MC3-containing lipid nanoparticles (1 mg/kg mRNA; i.v.; single injection) deliver mRNA to mouse liver and spleen with high efficacy^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

C57BL/6J (6-8 weeks old)^[1]
Dosage:

1 mg/kg mRNA
Administration:

i.v.; single injection
Result:

Exhibited high luminescence intensity per mg liver or spleen tissue.

Chemical Information

CAS No. 2870681-06-2
Appearance Liquid
분자량 614.04
화학식 C₄₁H₇₅NO₂
SMILES

CN(C)CCCC(OC(CCCCCCC/C=C\C/C=C\CCCCC)CCCCCCC/C=C\C/C=C\CCCCC)=O
선적

Room temperature in continental US; may vary elsewhere.
보관

Solution, -20°C, 2 years

순도&문서

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (263 KB)
SDS (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Ciufolini M A, et al. MC3-TYPE LIPIDS AND USE THEREOF IN THE PREPARATION OF LIPID NANOPARTICLES. WO/2022/246571. WIPO. 01.12.2022.

Calculators

몰농도 계산기

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

농도 희석 계산기

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

Keywords

MOQ

Minimum order quantity

100 mg

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