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Cat. No.: HY-161352

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NPI52

NPI52 (Compound E1) is a foot-and-mouth disease virus 3C protease (FMDV 3Cpro) inhibitor, with IC₅₀ values of 0.05 and 0.11 µM in FRET and cell-based assay, respectively.

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CAS No.: 1429218-68-7
화학식: C₃₄H₄₀N₄O₆
분자량:600.70

보관:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (268 KB)

NPI52 Chemical Structure

CAS No.: 1429218-68-7

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- 제품 설명
- IC₅₀ & Target
- Cellular Effect
Chemical Information
순도&문서
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

제품 설명

NPI52 (Compound E1) is a foot-and-mouth disease virus 3C protease (FMDV 3Cpro) inhibitor, with IC₅₀ values of 0.05 and 0.11 µM in FRET and cell-based assay, respectively^[1].

IC₅₀ & Target

Foot-and-mouth Disease Virus 3C Protease (FMDV 3Cpro)^[1]

Cellular Effect

Cell Line	Type	Value	Description	References
CCRF-CEM	CC₅₀	39.5 μM Compound: 1	Cytotoxicity against human CEM cells assessed as reduction in cell viability after 6 days by trypan blue exclusion assay Cytotoxicity against human CEM cells assessed as reduction in cell viability after 6 days by trypan blue exclusion assay	[PMID: 29779977]
Huh-7	CC₅₀	>10 μM Compound: 1	Cytotoxicity against human HuH7 cells assessed as reduction in cell viability Cytotoxicity against human HuH7 cells assessed as reduction in cell viability	[PMID: 29779977]
PBMC	CC₅₀	28.4 μM Compound: 1	Cytotoxicity against human PBMC assessed as reduction in cell viability after 6 days by trypan blue exclusion assay Cytotoxicity against human PBMC assessed as reduction in cell viability after 6 days by trypan blue exclusion assay	[PMID: 29779977]
Vero	CC₅₀	>100 μM Compound: 1	Cytotoxicity against African green monkey Vero cells assessed as reduction in cell viability after 3 days by hemocytometer Cytotoxicity against African green monkey Vero cells assessed as reduction in cell viability after 3 days by hemocytometer	[PMID: 29779977]

Chemical Information

CAS No. 1429218-68-7
분자량 600.70
화학식 C₃₄H₄₀N₄O₆
SMILES

O=C(N[C@@H](CC1=C(C=CC=C2)C2=CC=C1)C(N[C@@H](CC(C)C)C(N[C@@H](C[C@H]3C(NCC3)=O)C=O)=O)=O)OCC4=CC=CC=C4
선적

Room temperature in continental US; may vary elsewhere.
보관

Please store the product under the recommended conditions in the Certificate of Analysis.

순도&문서

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (268 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Kim Y, et al. Potent small molecule inhibitors against the 3C protease of foot-and-mouth disease virus. Microbiol Spectr. 2024 Mar 11:e0337223. [Content Brief]

Calculators

몰농도 계산기

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

농도 희석 계산기

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

100 mg

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