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Cat. No.: HY-182613

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NSC-2888

NSC-2888 is a Rho kinase II (ROCK-II) inhibitor with an IC₅₀ of 8.4 nM against human targets. NSC-2888 inhibits enzymatic activity by binding to active site amino acids via hydrogen bonds and hydrophobic interactions. NSC-2888 induces relaxation of pre-contracted rat aortic strips. NSC-2888 can be used in research related to hypertension.

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CAS No.: 5335-14-8
화학식: C₈H₁₈O₂S₂
분자량:210.36

보관:

Please store the product under the recommended conditions in the Certificate of Analysis.

NSC-2888 Chemical Structure

CAS No.: 5335-14-8

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
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- In Vitro
Chemical Information
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Biological Activity

제품 설명

In Vitro

NSC-2888 induces vasodilation in isolated rat aortas with an IC₅₀ of 8.5 nM^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 5335-14-8
분자량 210.36
화학식 C₈H₁₈O₂S₂
SMILES

OCCSCCC(C)SCCO
선적

Room temperature in continental US; may vary elsewhere.
보관

Please store the product under the recommended conditions in the Certificate of Analysis.

순도&문서

Handling Instructions (2659 KB)

References

[1]. Kesar S, et al. Identification of Novel Rho-Kinase-II Inhibitors with Vasodilatory Activity. ACS Med Chem Lett. 2020;11(9):1694-1703. Published 2020 Aug 4. [Content Brief]

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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