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Cat. No.: HY-148122

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NW 1028

NW 1028 is a potent VCP/p97 inhibitor. NW 1028 targets the ND1L domain of p97 and inhibits the degradation of a p97-dependent reporter. NW 1028 has good binding affinity with K_d values of 100 and 285 nM for ND1L and full length p97, respectively. NW 1028 has the function of regulating the mitotic spindle of cells.

연구목적의 판매만을 진행합니다. 환자를 대상으로 한 판매는 하지 않습니다.

CAS No.: 2749599-78-6
화학식: C₁₉H₂₁N₅O₄S
분자량:415.47

보관:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (271 KB)

NW 1028 Chemical Structure

CAS No.: 2749599-78-6

Amount: USD 0.00

* 장바구니에 담기 전 물품의 수량을 선택해 주십시오.

Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- 제품 설명
- In Vitro
Chemical Information
순도&문서
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

제품 설명

In Vitro

NW1028 (0.1-10 µM) inhibits the ATPase activity of the D1 domain and do not impact the ATPase activity of the D2 domain^[1].
NW1028 (0.0001-100 µM; 72 h; HeLa K cells) does not cause cell death and does not activate the UPR response^[1].
NW1028 (10 μM; HeLa cells) affects the orientation of the mitotic spindle. NW1028 has a spindle orientation defect in the z axis with 53.9%, compared to 14.9% cells in control conditions^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. .

Chemical Information

CAS No. 2749599-78-6
분자량 415.47
화학식 C₁₉H₂₁N₅O₄S
SMILES

O=C(C1=CC(NC(N2)=S)=C(C=C1)C2=O)N3[C@H](C(N4[C@H](C(N)=O)CCC4)=O)CCC3
선적

Room temperature in continental US; may vary elsewhere.
보관

Please store the product under the recommended conditions in the Certificate of Analysis.

순도&문서

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (271 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Figuerola-Conchas A, et, al. Small-Molecule Modulators of the ATPase VCP/p97 Affect Specific p97 Cellular Functions. ACS Chem Biol. 2020 Jan 17;15(1):243-253. [Content Brief]

Calculators

몰농도 계산기

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

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Molecular Weight Molecular Weight

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Concentration _(final) Concentration _(final)

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

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MOQ

Minimum order quantity

100 mg

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