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Cat. No.: HY-182513

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ONO-8539

ONO-8539 is an orally active prostanoid EP1 receptor antagonist with competitive, insurmountable binding and slow receptor dissociation for long-duration inhibition. ONO-8539 modulates afferent nerve function related to bladder activity, inhibits detrusor overactivity-related contractions, decreases nonvoiding contractions and voiding duration, and increases uroflow rate with ATP (HY-B2176)-induced detrusor overactivity. ONO-8539 attenuates acid-induced heartburn symptoms, extends time to first heartburn sensation, and prevents primary hypersensitivity after distal esophageal acidification. ONO-8539 can be used for the research of overactive bladder and gastroesophageal reflux disease.

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CAS No.: 459842-29-6
화학식: C₂₅H₂₈N₂O₅S₂
분자량:500.63

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Please store the product under the recommended conditions in the Certificate of Analysis.

ONO-8539 Chemical Structure

CAS No.: 459842-29-6

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

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- 제품 설명
- IC₅₀ & Target
- Clinical Trial
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Biological Activity

제품 설명

IC₅₀ & Target

EP1

All Prostaglandin Receptor Isoforms :

Clinical Trial

NCT Number	Sponsor	Condition	Start Date	Phase A549
NCT01329991	Plexxikon\|		2011-05	PHASE1

Chemical Information

CAS No. 459842-29-6
분자량 500.63
화학식 C₂₅H₂₈N₂O₅S₂
SMILES

O=C(C1=CC=C(COC2=C(N(S(=O)(C3=NC=CS3)=O)CC(C)C)C=C(CCC4)C4=C2)C(C)=C1)O
선적

Room temperature in continental US; may vary elsewhere.
보관

Please store the product under the recommended conditions in the Certificate of Analysis.

순도&문서

Handling Instructions (2659 KB)

References

[1]. Chapple CR, et al. Phase II study on the efficacy and safety of the EP1 receptor antagonist ONO-8539 for nonneurogenic overactive bladder syndrome. J Urol. 2014;191(1):253-260. [Content Brief]

[2]. Kondo T, et al. A novel prostanoid EP1 receptor antagonist, ONO-8539, reduces acid-induced heartburn symptoms in healthy male volunteers: a randomized clinical trial. J Gastroenterol. 2017;52(10):1081-1089. [Content Brief]

[3]. Naganawa A, et al. Optimization of sulfonamide derivatives as highly selective EP1 receptor antagonists. Bioorg Med Chem. 2006 Dec 1;14(23):7774-89. [Content Brief]

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How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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ONO-8539

All Prostaglandin Receptor Isoforms

Biological Activity

Chemical Information

순도&문서

References

Calculators

Help & FAQs

ONO-8539 Related Classifications

HY-182513 Related Classifications