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Cat. No.: HY-184689

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ORS-14

ORS-14 is a LILRB4/ILT3 ligand with a K_d of 85.2 nM for human receptors. ORS-14 blocks SCG2-mediated LILRB4 signaling pathway, reverses SCG2-mediated immunosuppression, restores cytokine production, reduces tumor cell viability, recovers cytotoxic T cell function, and increases the frequency of granzyme B⁺ CD8⁺ T cells. ORS-14 can be used in research related to colorectal cancer and acute myeloid leukemia.

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CAS No.: 1311892-52-0
화학식: C₁₇H₁₇N₅O₂
분자량:323.35

보관:

Please store the product under the recommended conditions in the Certificate of Analysis.

ORS-14 Chemical Structure

CAS No.: 1311892-52-0

Amount: USD 0.00

* 장바구니에 담기 전 물품의 수량을 선택해 주십시오.

Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- 제품 설명
- IC₅₀ & Target
- In Vitro
Chemical Information
순도&문서
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

제품 설명

IC₅₀ & Target

^[1]

LILRB4

85.2 nM (Kd)

In Vitro

OthersImmune Tolerance & ImmunosuppressionCytokines & ChemokinesAnti-cancerAdaptive Immunity

Others

ORS-14 directly binds to the extracellular domain of recombinant human LILRB4, with a K_D of 85.2 nM^[1].

Immune Tolerance & Immunosuppression

Cytokines & Chemokines

Anti-cancer

ORS-14 reverses the immunosuppressive effect mediated by SCG2 in the co-culture system of PBMC and HCT116 colorectal cancer cells, restores cytokine secretion and reduces tumor cell viability^[1].

Immune Tolerance & Immunosuppression

Adaptive Immunity

Cytokines & Chemokines

Anti-cancer

ORS-14 reverses the SCG2-mediated immunosuppressive effect in the co-culture system of PBMC and THP-1 AML, restores IFN-γ secretion, enhances cytotoxic T cell activity, and reduces tumor cell viability^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Related Protocols :

Chemical Information

CAS No. 1311892-52-0
분자량 323.35
화학식 C₁₇H₁₇N₅O₂
SMILES

O=C(NCC1=CC=NC(OC2=CC=C(C)C(C)=C2)=C1)C3=CNN=N3
선적

Room temperature in continental US; may vary elsewhere.
보관

Please store the product under the recommended conditions in the Certificate of Analysis.

순도&문서

Handling Instructions (2659 KB)

References

[1]. Abdel-Rahman SA, et al. OracleScreen-LILRB4 (HTS-Oracle v3): machine learning-guided discovery of myeloid immune checkpoint binders validated in patient-derived cells. Bioorganic & medicinal chemistry letters. 2026 Jun 29;140:130717. [Content Brief]

Calculators

몰농도 계산기

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

농도 희석 계산기

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

Keywords

MOQ

Minimum order quantity

100 mg

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