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Cat. No.: HY-184688

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ORS-22

ORS-22 is an immunomodulator with a K_d value of 9.2 nM for human LILRB4. ORS-22 binds directly to the extracellular domain of LILRB4, reverses immunosuppression, restores cytotoxic T cell function, recovers cytokine production, and reduces tumor cell viability. ORS-22 can be used in research related to colorectal cancer and acute myeloid leukemia.

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CAS No.: 1311612-43-7
화학식: C₁₆H₁₈N₆OS
분자량:342.42

보관:

Please store the product under the recommended conditions in the Certificate of Analysis.

ORS-22 Chemical Structure

CAS No.: 1311612-43-7

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- 제품 설명
- IC₅₀ & Target
- In Vitro
Chemical Information
순도&문서
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

제품 설명

IC₅₀ & Target^[1]

LILRB4

9.2 nM (Kd)

In Vitro

ORS-22 binds directly to recombinant human LILRB4 extracellular domain with a high affinity, exhibiting a K_D of 9.2 nM^[1].
ORS-22 (1 μM; 72 h) restores anti-tumor immune activity in SCG2-suppressed PBMC and HCT116 colorectal cancer co-cultures, enhancing cytokine secretion and reducing tumor cell viability^[1].
ORS-22 (1 μM; 72 h) restores anti-tumor immune activity in SCG2-suppressed PBMC and THP-1 AML co-cultures, enhancing cytokine secretion, activating cytotoxic T cells, and reducing AML cell viability^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 1311612-43-7
분자량 342.42
화학식 C₁₆H₁₈N₆OS
SMILES

CN(CC(N1CCN2C(C1)=NN=C2C)=O)C3=NC4=C(S3)C=CC=C4
선적

Room temperature in continental US; may vary elsewhere.
보관

Please store the product under the recommended conditions in the Certificate of Analysis.

순도&문서

Handling Instructions (2659 KB)

References

[1]. Abdel-Rahman SA, et al. OracleScreen-LILRB4 (HTS-Oracle v3): machine learning-guided discovery of myeloid immune checkpoint binders validated in patient-derived cells. Bioorganic & medicinal chemistry letters. 2026 Jun 29;140:130717. [Content Brief]

Calculators

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Concentration _(start) Concentration _(start)

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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MOQ

Minimum order quantity

100 mg

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