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Cat. No.: HY-150078

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OX01914

OX01914 is a water-solube and permeable utrophin modulator (upregulates utrophin protein levels), with an EC₅₀ of 20.5 μM. OX01914 can be used in study of duchenne muscular dystrophy (DMD).

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CAS No.: 49676-35-9
화학식: C₁₇H₁₄N₄O
분자량:290.32

보관:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (273 KB)

OX01914 Chemical Structure

CAS No.: 49676-35-9

Amount: USD 0.00

* 장바구니에 담기 전 물품의 수량을 선택해 주십시오.

Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- 제품 설명
- In Vitro
Chemical Information
순도&문서
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

제품 설명

In Vitro

OX01914 (0.1, 10, 40, 50 μM; 24 h) upregulates utrophin mRNA in LUmdx and (30 μM; 24 h) H2K mdx myoblasts^[1].
OX01914 (1, 3, 30; 24 h) upregulates utrophin protein levels in human DMD muscle cells^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. .

Western Blot Analysis^[1]

View Protocol

Cell Line:

LUmdx and H2K mdx myoblasts
Concentration:

0.1, 10, 40, 50 µM (for LUmdx myoblasts) ; 30 µM (for H2K mdx myoblasts).
Incubation Time:

24 h
Result:

Upregulated utrophin mRNA both in LUmdx and H2K mdx myoblasts.

Western Blot Analysis^[1]

View Protocol

Cell Line:

Human DMD cells
Concentration:

1, 3, 30 µM
Incubation Time:

24 h
Result:

Increased utrophin protein levels by approximately 3-fold.

Chemical Information

CAS No. 49676-35-9
분자량 290.32
화학식 C₁₇H₁₄N₄O
SMILES

O=C(NN)C1=NC(C2=CC=CC=C2)=CC(C3=CC=CC=C3)=N1
선적

Room temperature in continental US; may vary elsewhere.
보관

Please store the product under the recommended conditions in the Certificate of Analysis.

순도&문서

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (273 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Vuorinen A, et al. Discovery and mechanism of action studies of 4,6-diphenylpyrimidine-2-carbohydrazides as utrophin modulators for the treatment of Duchenne muscular dystrophy. Eur J Med Chem. 2021 Aug 5;220:113431. [Content Brief]

Calculators

몰농도 계산기

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

농도 희석 계산기

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

Keywords

MOQ

Minimum order quantity

100 mg

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