P-1946
P-1946 is a HIV protease inhibitor with a human HIV-1 protease Ki of 2.600 nM. P-1946 has potent and selective in vitro antiviral activity and retains full antiviral activity against HIV isolates resistant to commercially available protease inhibitors. P-1946 can be used for the research of human immunodeficiency virus type 1 (HIV-1) infection.
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- CAS No.: 449806-40-0
- 화학식: C29H41N5O6S
- 분자량:587.73
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보관:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Protocol
- 순도&문서
- References
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Help & FAQs
Biological Activity
제품 설명
IC50 & Target
[1]|
HIV-1 2.6 nM (Ki) |
In Vitro
P-1946 potently and selectively inhibits wild-type HIV-1 protease with a Ki of 2.600 ± 0.076 nM, while displaying weak activity against human cathepsin D and porcine pepsin (IC50 ≥30 μM)[1].
P-1946 (6 days) potently inhibits replication of wild-type HIV-1 strains NL4-3 and RF in MT-4 cells with EC50 values of 152 nM and 136 nM, respectively, has a CC50 of 40 μM, and a selectivity index of 263 for MT-4 cells[1].
P-1946 (6 days) retains full antiviral activity against 8 of 11 PI-resistant HIV-1 strains in MT-4 cells or via PhenosenseTM assay[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 449806-40-0
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분자량 587.73
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화학식 C29H41N5O6S
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SMILES
O=S(N(CC(C)C)[C@H](CO)CCCCNC([C@@H](NC(OC)=O)CC1=CNC2=CC=CC=C12)=O)(C3=CC=C(C=C3)N)=O
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선적
Room temperature in continental US; may vary elsewhere.
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보관
Please store the product under the recommended conditions in the Certificate of Analysis.
순도&문서
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
P-1946 Related Classifications
HY-182316 Related Classifications
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Keywords
- P-1946
- 449806-40-0
- P1946
- P 1946
- HIV Protease
- HIV
- Human immunodeficiency virus
- porcine pepsin
- human immunodeficiency virus type 1 (HIV-1) infection
- antiviral agent
- HIV-1 protease
- human cathepsin D
- MT-4 cells
- HIV drug resistance mutations
- porcine cellular aspartyl protease
- human cellular aspartyl protease
- HIV isolates
- Inhibitor
- inhibitor
- inhibit