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Cat. No.: HY-114797

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PDE5-IN-16

PDE5-IN-16 is a selective phosphodiesterase type 5 (PDE5) inhibitor with an IC₅₀ of 0.8 nM. PDE5-IN-16 enhances the relaxation of corpus cavernosum tissue strips. PDE5-IN-16 is applicable for the research of erectile dysfunction.

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CAS No.: 261769-44-2
화학식: C₂₃H₂₃ClN₆O₂
분자량:450.93

보관:

Please store the product under the recommended conditions in the Certificate of Analysis.

PDE5-IN-16 Chemical Structure

CAS No.: 261769-44-2

Amount: USD 0.00

* 장바구니에 담기 전 물품의 수량을 선택해 주십시오.

Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- 제품 설명
- In Vitro
- Parmacokinetics
- In Vivo
Chemical Information
순도&문서
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

제품 설명

All Phosphodiesterase (PDE) Isoforms :

In Vitro

PDE5-IN-16 (Compound 5) potently inhibits human platelet PDE5 with an IC₅₀ of 0.8 nM and exhibits high selectivity over bovine heart PDE1, rat kidney PDE2, human platelet PDE3, rat kidney PDE4, and bovine retina PDE6^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. .

Parmacokinetics

Species	Dose	Route	Bioavailability	T_1/2
Rat^[1]	21 μmol/Kg	p.o.	33 %	1.2 h
Dog^[1]	23 μmol/Kg	p.o.	66 %	2.3 h

In Vivo

PDE5-IN-16 (Compound 5) (10-250 mg/kg; p.o.) shows no drug-related adverse effects in Rattus norvegicus at oral doses up to 50 mg/kg, with only mild body weight reduction in male rats at 250 mg/kg^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 261769-44-2
분자량 450.93
화학식 C₂₃H₂₃ClN₆O₂
SMILES

O=C(NCC=1C=CN=CC1)C2=CN=C3C(C=NN3CC)=C2NCC4=CC=C(OC)C(Cl)=C4
선적

Room temperature in continental US; may vary elsewhere.
보관

Please store the product under the recommended conditions in the Certificate of Analysis.

순도&문서

Handling Instructions (2659 KB)

References

[1]. Yu G, et al. Substituted pyrazolopyridines as potent and selective PDE5 inhibitors: potential agents for treatment of erectile dysfunction. J Med Chem. 2001 Mar 29;44(7):1025-7.
[Content Brief]

Calculators

몰농도 계산기

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

농도 희석 계산기

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

Keywords

MOQ

Minimum order quantity

100 mg

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