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Cat. No.: HY-N15582

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Perezone

Perezone is a sesquiterpenoid benzoquinone found in the roots of Acourtia species. Perezone inhibits the activity of leukemia cell line K-562 and human glioma cell line U-251 (IC₅₀: 6.83 μM). Perezone increases the expression of caspase 3, 8, and 9 genes associated with apoptosis. Perezone has antioxidant and anti-inflammatory activities.

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CAS No.: 3600-95-1
화학식: C₁₅H₂₀O₃
분자량:248.32

보관:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (267 KB)

Perezone Chemical Structure

CAS No.: 3600-95-1

Amount: USD 0.00

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- 제품 설명
- Cellular Effect
Chemical Information
순도&문서
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

제품 설명

Cellular Effect

Cell Line	Type	Value	Description	References
HCT-15	IC₅₀	10.3 μM Compound: 1, Perezone	Cytotoxicity against human HCT15 cells after 48 hrs by SRB assay Cytotoxicity against human HCT15 cells after 48 hrs by SRB assay	[PMID: 22858298]
K562	IC₅₀	3 μM Compound: 1, Perezone	Cytotoxicity against human K562 cells after 48 hrs by SRB assay Cytotoxicity against human K562 cells after 48 hrs by SRB assay	[PMID: 22858298]
PC-3	IC₅₀	6.5 μM Compound: 1, Perezone	Cytotoxicity against human PC3 cells after 48 hrs by SRB assay Cytotoxicity against human PC3 cells after 48 hrs by SRB assay	[PMID: 22858298]
SK-LU-1	IC₅₀	4.2 μM Compound: 1, Perezone	Cytotoxicity against human SKLU1 cells after 48 hrs by SRB assay Cytotoxicity against human SKLU1 cells after 48 hrs by SRB assay	[PMID: 22858298]

Chemical Information

CAS No. 3600-95-1
분자량 248.32
화학식 C₁₅H₂₀O₃
SMILES

C/C(C)=C\CC[C@H](C1=C(C(C(C)=CC1=O)=O)O)C
Structure Classification
- Terpenoids
- Sesquiterpenes
Initial Source
선적

Room temperature in continental US; may vary elsewhere.
보관

Please store the product under the recommended conditions in the Certificate of Analysis.

순도&문서

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (267 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Gómez-Serrano G, et al. Time-dependent perezone production in different culture systems of Acourtia cordata[J]. Central European Journal of Biology, 2012, 7: 507-518.

[2]. Escobedo-González R G, et al. Characterization and comparison of perezone with some analogues. Experimental and theoretical study[J]. Journal of Molecular Structure, 2015, 1097: 98-105.

[3]. Estévez-Carmona MM, et al. Perezone and its phenyl glycine derivative induce cytotoxicity via caspases on human glial cancer cells. Nat Prod Res. 2024 Jun;38(11):1823-1833. [Content Brief]

[4]. Concepción Lozada M, et al. Synthesis, cytotoxic and antioxidant evaluations of amino derivatives from perezone. Bioorg Med Chem. 2012 Sep 1;20(17):5077-84. [Content Brief]

[5]. Martínez J, et al. Computational Characterization of Perezone, Isoperezone and their Sulfur‐Derivatives: Anti‐inflammatory Activity[J]. ChemistrySelect, 2019, 4(45): 13333-13346.

Calculators

몰농도 계산기

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

농도 희석 계산기

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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MOQ

Minimum order quantity

100 mg

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