country

Change Language

EN - English
FR - Français
DE - Deutsch
ES - Español
JA - 日本語
KO - 한국어

Country or Region:

United States

Product Name	Size / Unit Price	Qty

Total: USD 0.00 Checkout

Cat. No.: HY-108327

Copy Link Print Information

PF-05020182

PF-05020182 is an orally active opener for Kv7 channel, that activates human Kv7.2/7.3, Kv7.4 and Kv7.3/7.5 with EC₅₀ of 334, 625 and 588 nM, respectively. PF-05020182 exhibits anticonvulsant activity in rats corneal electric shock-induced tonic seizure (MES) models. PF-05020182 is blood-brain barrier (BBB) penetrable.

연구목적의 판매만을 진행합니다. 환자를 대상으로 한 판매는 하지 않습니다.

CAS No.: 1354712-92-7
화학식: C₁₈H₃₀N₄O₄
분자량:366.46

보관:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (266 KB)

PF-05020182 Chemical Structure

CAS No.: 1354712-92-7

Amount: USD 0.00

* 장바구니에 담기 전 물품의 수량을 선택해 주십시오.

Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- 제품 설명
- Cellular Effect
Chemical Information
순도&문서
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

제품 설명

Cellular Effect

Cell Line	Type	Value	Description	References
CHO-K1	EC₅₀	1327 nM Compound: 2, PF-05020182	Activation of rat Kv7.3/7.5 expressed in CHOK1 cells Activation of rat Kv7.3/7.5 expressed in CHOK1 cells	[PMID: 25987375]
CHO-K1	EC₅₀	294 nM Compound: 2, PF-05020182	Activation of rat Kv7.2/7.3 expressed in CHOK1 cells Activation of rat Kv7.2/7.3 expressed in CHOK1 cells	[PMID: 25987375]
CHO-K1	EC₅₀	334 nM Compound: 2, PF-05020182	Activation of human Kv7.2/7.3 expressed in CHOK1 cells Activation of human Kv7.2/7.3 expressed in CHOK1 cells	[PMID: 25987375]
CHO-K1	EC₅₀	376 nM Compound: 2, PF-05020182	Activation of rat Kv7.4 expressed in CHOK1 cells Activation of rat Kv7.4 expressed in CHOK1 cells	[PMID: 25987375]
CHO-K1	EC₅₀	588 nM Compound: 2, PF-05020182	Activation of human Kv7.3/7.5 expressed in CHOK1 cells Activation of human Kv7.3/7.5 expressed in CHOK1 cells	[PMID: 25987375]
CHO-K1	EC₅₀	625 nM Compound: 2, PF-05020182	Activation of human Kv7.4 expressed in CHOK1 cells Activation of human Kv7.4 expressed in CHOK1 cells	[PMID: 25987375]
CHO-K1	EC₅₀	>100000 nM Compound: 2, PF-05020182	Activation of human Kv7.1/KCNE1 expressed in CHOK1 cells Activation of human Kv7.1/KCNE1 expressed in CHOK1 cells	[PMID: 25987375]

Chemical Information

CAS No. 1354712-92-7
분자량 366.46
화학식 C₁₈H₃₀N₄O₄
SMILES

O=C(CC(C)(C)C)NC1=C(OC)N=C(N2CCC(CC2)OC)N=C1OC
선적

Room temperature in continental US; may vary elsewhere.
보관

Please store the product under the recommended conditions in the Certificate of Analysis.

순도&문서

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (266 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Davoren JE, et al., Discovery of a novel Kv7 channel opener as a treatment for epilepsy. Bioorg Med Chem Lett. 2015 Nov 1;25(21):4941-4944. [Content Brief]

Calculators

몰농도 계산기

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

농도 희석 계산기

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

Keywords

MOQ

Minimum order quantity

100 mg

견적 받기 해외재고보유

Other size

견적 받기