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Cat. No.: HY-N14405

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Phenazostatin A

Phenazostatin A is a phenazine Substance that has the protective effect of new neuron cells. Phenazostatin A can scavenge free radicals, protect N18-RE 105 nerve cells from glutamate toxicity, and inhibit lipid peroxidation. Phenazostatin A inhibits glutamate toxicity in N18-RE-105 cells with an EC₅₀ of 0.34 μg/mL.

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CAS No.: 185614-22-6
화학식: C₂₈H₂₀N₄O₃
분자량:460.48

보관:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (267 KB)

Phenazostatin A Chemical Structure

CAS No.: 185614-22-6

Amount: USD 0.00

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity

제품 설명

Chemical Information

CAS No. 185614-22-6
분자량 460.48
화학식 C₂₈H₂₀N₄O₃
SMILES

O=C(C1=CC=CC2=NC3=C(C(C)OC4=CC=C5N=C6C=CC=CC6=NC5=C4)C=CC=C3N=C21)OC
Structure Classification
- Antibiotics
- Other Antibiotics
Initial Source
- Microorganisms
선적

Room temperature in continental US; may vary elsewhere.
보관

Please store the product under the recommended conditions in the Certificate of Analysis.

Protocol

All Signal Pathway Related

Ferroptosis Solutions
Ferroptosis is an iron-dependent, non-apoptotic form of regulated cell death characterized by lethal lipid peroxidation and sensitivity to suppression by iron chelators or lipophilic radical-trapping antioxidants. The core pathway links cystine uptake through system Xc−, glutathione availability, GPX4-dependent detoxification of phospholipid hydroperoxides, iron-dependent oxidative reactions, and polyunsaturated-phospholipid metabolism into a cell-death program that is biochemically and morphologically distinct from apoptosis, necrosis, and autophagy. The ferroptosis pathway is experimentally linked to phenotype through chemical and genetic perturbation. Erastin induces ferroptosis by inhibiting cystine uptake through system Xc− and weakening antioxidant defenses, while GPX4 inhibition or depletion causes lipid peroxide accumulation and ferroptotic cancer-cell death. ACSL4 and oxidizable arachidonoyl- or adrenoyl-containing phosphatidylethanolamines shape ferroptosis sensitivity by con

순도&문서

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (267 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. W G Kim, et al. New diphenazines with neuronal cell protecting activity, phenazostatins A and B, produced by Streptomyces sp. J Antibiot (Tokyo). 1997 Sep;50(9):715-21. [Content Brief]

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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MOQ

Minimum order quantity

100 mg

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