Picoberin
Picoberin is a low picomolar inhibitor of Hedgehog-induced osteoblast differentiation. Picoberin is a potent aryl hydrocarbon receptor (AhR) agonist. Picoberin inhibits Wnt3A-induced osteoblast differentiation of C3H10T1/2 cells. Picoberin can upregulate genes encoding phase I and II metabolic enzymes.
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- CAS No.: 3034663-23-2
- 화학식: C17H13BrClNO
- 분자량:362.65
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보관:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
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Biological Activity
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| C3H 10T1/2 | IC50 |
0.003 nM
Compound: 3l
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Inhibition of Hedgehog-signalling dependent purmorphamine induced osteoblast differentiation in mouse C3H 10T1/2 cells assessed as reduction in ALP expression incubated for 96 hrs by CDP-Star luminogenic substrate based assay
Inhibition of Hedgehog-signalling dependent purmorphamine induced osteoblast differentiation in mouse C3H 10T1/2 cells assessed as reduction in ALP expression incubated for 96 hrs by CDP-Star luminogenic substrate based assay
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[PMID: 36459434] |
Chemical Information
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CAS No. 3034663-23-2
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분자량 362.65
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화학식 C17H13BrClNO
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SMILES
O=C1N2[C@@H](CC3=CC(Cl)=C(C=C31)Br)C4=C(CC2)C=CC=C4
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선적
Room temperature in continental US; may vary elsewhere.
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보관
Please store the product under the recommended conditions in the Certificate of Analysis.
순도&문서
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Picoberin Related Classifications
HY-148637 Related Classifications
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