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Cat. No.: HY-P99887

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Biologically Validated

Pimivalimab

Name: Pimivalimab
Brand: MedChemExpress
SKU: HY-P99887
Price: 500.00 USD
Availability: InStock
Rating: 5 (1 reviews)

(Synonyms: JTX-4014)

고객리뷰

Based on 1 Customer Validation

Pimivalimab (JTX-4014) is an anti-PD-1 IgG4 monoclonal antibody. Pimivalimab binds to PD-1, blocking its interaction with PD-L1 and PD-L2, and enhances antitumor immune activity. Pimivalimab can be used for research on advanced or metastatic renal cell carcinoma and metastatic non-small cell lung cancer.

연구목적의 판매만을 진행합니다. 환자를 대상으로 한 판매는 하지 않습니다.

CAS No.: 2293951-22-9
분자량:144.9 kDa

보관:

Shipping with dry ice

Please store the product under the recommended conditions in the Certificate of Analysis.

Pimivalimab Chemical Structure

CAS No.: 2293951-22-9

사이즈

가격

재고

수량

Amount: USD 0.00

* 장바구니에 담기 전 물품의 수량을 선택해 주십시오.

Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- 제품 설명
- Isotype
- Recommend Isotype Controls
- Species Reactivity
- IC₅₀ & Target
- In Vitro
- Clinical Trial
- Gene ID
- Accession
- Conjugated
- Reconstitution
- Format
- 신청
- Verified Bioactivity
Chemical Information
순도&문서
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

제품 설명

Isotype

Human IgG4 kappa

Recommend Isotype Controls

Human IgG4 (S228P) kappa, Isotype Control

Species Reactivity

Human

IC₅₀ & Target

PDCD1/PD-1/CD279

In Vitro

Immune Tolerance and ImmunosuppressionAnti-cancer

Immune Tolerance and Immunosuppression

Anti-cancer

Pimivalimab (JTX-4014) is a fully human IgG4 monoclonal antibody targeting PD-1. The IgG4 subtype is selected to reduce antibody-dependent cell-mediated cytotoxicity or complement-dependent cytotoxicity against normal effector T cells expressing PD-1, thereby protecting anti-tumor immune cells^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Clinical Trial

NCT Number	Sponsor	Condition	Start Date	Phase A549
NCT01329991			2011-05	PHASE1

Gene ID

5133 [NCBI]

Accession

Q15116

Conjugated

Unconjugated

Reconstitution

The product can be reconstituted/diluted with sterile PBS or saline.

Format

Human IgG4 kappa

신청

ELISA, FACS, Functional assay

Verified Bioactivity

Immobilized PD-1 Protein, Human (143a.a, HEK293, His, HY-P7396) can bind Pimivalimab. The EC₅₀ for this effect is 4.21 ng/mL.

Chemical Information

CAS No. 2293951-22-9
Appearance Liquid
분자량 144.9 kDa
Color Colorless to light yellow
SMILES

[Pimivalimab]
Synonyms

JTX-4014
선적

Shipping with dry ice.
Formulation

Please refer to the lot-specific COA for specific buffer information.
보관

Please store the product under the recommended conditions in the Certificate of Analysis.

순도&문서

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (267 KB)
SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Inhibitory Antibodies User Guide (603 KB)

References

[1]. Lara Jr P N, et al. Leukocyte immunoglobulin-like receptor (LILRB2)-targeted JTX-8064 plus the anti-PD1 inhibitor JTX-4014 (pimivalimab) in immune-checkpoint inhibitor (ICl) pretreated patients (pts) with advanced or metastatic renal cell cancer (mRCC): Results from the multi-stage phase 1-2 INNATE trial[J]. 2024.

[2]. Feng Y, et al. Target neutrophil heterogeneity and plasticity in cancer. Journal of hematology & oncology. 2025 Aug 12;18(1):79.

[3]. Papadopoulos KP, et al. Phase I, first-in-human trial of programmed cell death receptor-1 (PD-1) inhibitor, JTX-4014, in adult patients with advanced, refractory, solid tumors. Cancer Immunol Immunother. 2021 Mar;70(3):763-772.

[4]. Kobziev O, et al. Phase 2 study of PD-1 inhibitor JTX-4014 alone and in combination with vopratelimab, an ICOS agonist, in biomarker-selected subjects with metastatic NSCLC after one prior platinum-containing regimen (SELECT)[J]. 2021.

Calculators

몰농도 계산기

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

농도 희석 계산기

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

Keywords

MOQ

Minimum order quantity

100 mg

견적 받기 해외재고보유

Other size

견적 받기

Amount: USD 0.00

Biological Activity
- 제품 설명
- Isotype
- Recommend Isotype Controls
- Species Reactivity
- IC₅₀ & Target
- In Vitro
- Clinical Trial
- Gene ID
- Accession
- Conjugated
- Reconstitution
- Format
- 신청
- Biological Activity
Chemical Information
순도&문서
References

상품명:
Cat. No.:
수량:
MCE Japan Authorized Agent:

상품명:
CAS No.:
Species:
Purity:
수량:

Pimivalimab

HOLO Human Interleukin-2 (IL-2) Detection Kit

Protein A Agarose

Bradford Protein Assay Kit

DPBS Buffer (1×)

PBS Buffer (1×)

Cytotoxicity LDH Assay Kit